Comparative Clinical Study of the Effect of Nigella Sativa Oil on Soft Tissue Healing and Inflammation Reduction Compared to Eugenol in the Context of Dry Socket

Alabdullah, Mohamad; Beit, Zafin Z Kara; Shehada, Asaad

doi:10.7759/cureus.35375

Cited by 2 publications

(3 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Biologically active compounds from Nigella sativa have been shown to have antioxidant, antimicrobial, antiinflammatory, antidiabetic, hepatoprotective, antiproliferative, proapoptotic, antiepileptic and immunomodulatory activities, among others [48][49][50][51][52][53][54]. Black seed could also be used for the prevention of some diseases, such as cardiovascular disease, diabetes, gastrointestinal diseases or wound healing [20,[55][56][57][58][59]. In clinical studies, Nigella sativa and its constituents, including TQ, have demonstrated antimicrobial, antioxidant, anti-inflammatory, anticancer and anti-diabetic properties, as well as therapeutic effects on metabolic syndrome and gastrointestinal, neural, cardiovascular, respiratory, urinary and reproductive disorders [54].…”

Section: Preclinical and Clinical Studies On Thymoquinone And Its Mai...mentioning

confidence: 99%

Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer

Kurowska,

Madej,

Strzalka-Mrozik

2023

CIMB

View full text Add to dashboard Cite

Colorectal cancer (CRC) is one of the most commonly diagnosed cancers and is responsible for approximately one million deaths each year. The current standard of care is surgical resection of the lesion and chemotherapy with 5-fluorouracil (5-FU). However, of concern is the increasing incidence in an increasingly younger patient population and the ability of CRC cells to develop resistance to 5-FU. In this review, we discuss the effects of thymoquinone (TQ), one of the main bioactive components of Nigella sativa seeds, on CRC, with a particular focus on the use of TQ in combination therapy with other chemotherapeutic agents. TQ exhibits anti-CRC activity by inducing a proapoptotic effect and inhibiting proliferation, primarily through its effect on the regulation of signaling pathways crucial for tumor progression and oxidative stress. TQ can be used synergistically with chemotherapeutic agents to enhance their anticancer effects and to influence the expression of signaling pathways and other genes important in cancer development. These data appear to be most relevant for co-treatment with 5-FU. We believe that TQ is a suitable candidate for consideration in the chemoprevention and adjuvant therapy for CRC, but further studies, including clinical trials, are needed to confirm its safety and efficacy in the treatment of cancer.

show abstract

Section: Preclinical and Clinical Studies On Thymoquinone And Its Mai...mentioning

confidence: 99%

Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer

Kurowska,

Madej,

Strzalka-Mrozik

2023

CIMB

View full text Add to dashboard Cite

show abstract

“…Os medicamentos extraídos de plantas e seus derivados apresentam grande eficácia no tratamento de feridas. Além de disponíveis e baratos, também são considerados seguros, pois raramente provocam reações alérgicas a eles (Alabdullah, 2023).…”

unclassified

“…, anti-inflamatórias, antibacterianas, antivirais, antifúngicas e atividades antioxidantes. Além disso, a N. sativa e seus compostos bioativos, como a timoquinona promovem a cicatrização de feridas e o reparo ósseo, mostrando que a planta tem propriedades terapêuticas promissoras que podem ser úteis para a alveolite(Khan et al, 2022;Alabdullah, 2023).Binshabaib et al (2022) comprovaram a eficácia antibacteriana in vitro da Melaleuca alternifolia (Maiden & Betche) Cheel. e a superioridade desta ação em relação à Saussurea costus contra bactérias orais.…”

unclassified

A Fitoterapia No Tratamento Da Alveolite: Uma Revisão Sistemática De Literatura

Ferreira Rocha,

Pombo Sudré da Silva,

Nocelle de Almeida

2024

RECIMA21

View full text Add to dashboard Cite

Dentre as principais complicações após a extração de dentes permanentes está a alveolite causada pela infecção de microrganismos no alvéolo, que ajudam a desintegrar o coágulo através da fibrinólise. Várias são as modalidades de tratamento para a alveolite; contudo, o uso de antibióticos de forma inadequada pode gerar resistência bacteriana. Os medicamentos extraídos de plantas e seus derivados apresentam grande eficácia no tratamento de feridas, entre elas, a alveolite. Além de disponíveis e baratos, também são considerados seguros, pois raramente provocam reações alérgicas a eles. O objetivo desse estudo foi realizar uma revisão sistemática da literatura sobre o uso de fitoterápicos, plantas medicinais, no tratamento da alveolite. A base de dados utilizada foi o Google Acadêmico com os seguintes termos de busca em inglês: “alveolitis”, “medicinal plant” e “dental extraction” com o intervalo temporal de janeiro de 2000 a agosto de 2023. Dois revisores (1º e 2º autores) avaliaram de forma independente os registros selecionando os artigos que atendiam aos critérios de elegibilidade. Os dados extraídos dos artigos foram planilhados no Excel, contemplando 22 variáveis, entre elas os principais princípios ativos relativos ao tratamento da alveolite. Observou-se que os documentos selecionados geraram uma gama de dados relevantes que poderão ser úteis para direcionar novos estudos.

show abstract

Comparative Clinical Study of the Effect of Nigella Sativa Oil on Soft Tissue Healing and Inflammation Reduction Compared to Eugenol in the Context of Dry Socket

Cited by 2 publications

References 19 publications

Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer

Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer

A Fitoterapia No Tratamento Da Alveolite: Uma Revisão Sistemática De Literatura

Contact Info

Product

Resources

About