Comparative clinical trial of S-adenosylmethionine versus nabumetone for the treatment of knee osteoarthritis: An 8-week, multicenter, randomized, double-blind, double-dummy, Phase IV study in Korean patients

Efficacy and Tolerability of Advanced Glycation End-Products Inhibitor in Osteoarthritis

“…Barcelo´et al 52 revealed both increased synthesis and proliferation rates of proteoglycan with SAMe in experimental OA in rabbits. Furthermore, many clinical studies have shown effectiveness of SAMe with respect to NSAIDs such as celecoxib, 50 nabumetone, 53 and naproxen 54 in reducing symptoms of OA.…”

The Role of Chondroprotectants, Nutraceuticals, and Nutrition in Rehabilitation

“…88 Progressive hypoxia resulting in production of reactive oxygen species may play a role in rheumatoid arthritis. 99 A systematic review was inconclusive and evidence of efficacy was hampered by inclusion of small trials of questionable quality. 90 S-Adenosylmethionine.…”

What about supplements for osteoarthritis? A critical and evidenced‐based review

“…This was reinforced in the latest phase 4 RCT by Kim et al that showed no significant benefit in Korean OA patients given SAMe versus NSAIDs. 43 In the Cochrane review of SAMe for OA of the knee or hip, four trials comprising 656 patients were included and compared with placebo. 44 In terms of effects on pain, function and safety outcomes, these experiments achieved inconclusive results and routine use of SAMe for OA patients was not recommended.…”