Comparative complete genome analysis of Indian type A foot-and-mouth disease virus field isolates

Subramaniam, Saravanan; Sanyal, Aniket; Mohapatra, Jajati K.; Hemadri, D.; Pattnaik, Bramhadev

doi:10.1007/s11262-011-0622-8

Cited by 10 publications

(5 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, previous comparative genomic studies of FMDV [7] have highlighted two instances of similar deletions for serotype A isolates from Argentina in 1959 and 1961 (AY593769 and AY593789) and one additional serotype C isolate from the UK in 1934 (AY593810). Likewise, a 41 nt deletion within the same region was found for serotype A viruses from India in 2009 (HQ832592) [34]. The results obtained in the present study using maximum likelihood analysis of the S-fragment and the VP1-coding region of isolates with and without deletions indicate that this deletion has arisen independently in these different serotypes and have not been transferred via recombination from a single event generated in one common ancestor.…”

Section: Discussionsupporting

confidence: 69%

Multiple introductions of serotype O foot-and-mouth disease viruses into East Asia in 2010–2011

Valdazo-González

Тимина

Scherbakov

et al. 2013

Vet Res

View full text Add to dashboard Cite

Foot-and-mouth disease virus (FMDV) is a highly contagious and genetically variable virus. Sporadic introductions of this virus into FMD-free countries may cause outbreaks with devastating consequences. In 2010 and 2011, incursions of the FMDV O/SEA/Mya-98 strain, normally restricted to countries in mainland Southeast Asia, caused extensive outbreaks across East Asia. In this study, 12 full genome FMDV sequences for representative samples collected from the People’s Republic of China (PR China) including the Hong Kong Special Administrative Region (SAR), the Republic of Korea, the Democratic People’s Republic of Korea, Japan, Mongolia and The Russian Federation were generated and compared with additional contemporary sequences from viruses within this lineage. These complete genomes were 8119 to 8193 nucleotides in length and differed at 1181 sites, sharing a nucleotide identity ≥ 91.0% and an amino acid identity ≥ 96.6%. An unexpected deletion of 70 nucleotides within the 5′-untranslated region which resulted in a shorter predicted RNA stem-loop for the S-fragment was revealed in two sequences from PR China and Hong Kong SAR and five additional related samples from the region. Statistical parsimony and Bayesian phylogenetic analysis provide evidence that these outbreaks in East Asia were generated by two independent introductions of the O/SEA/Mya-98 lineage sometime between August 2008 and March 2010. The rapid emergence of these viruses from Southeast Asia highlights the importance of adopting approaches to closely monitor the spread of this lineage that now poses a threat to livestock industries in other regions.

show abstract

Section: Discussionsupporting

confidence: 69%

Multiple introductions of serotype O foot-and-mouth disease viruses into East Asia in 2010–2011

Valdazo-González

Тимина

Scherbakov

et al. 2013

Vet Res

View full text Add to dashboard Cite

show abstract

“…FMDV serotype A topotype Asia, genotype 18 has been the only genotype present in India since 2001. This genotype is further classified into the VP3 59 ‐deletion and non‐deletion groups (Mohapatra et al., ; Subramaniam et al, ). Genotype 18 has also been found in Bangladesh in recent years (Mohapatra et al., ; Nandi et al., ; WRLFMD, ).…”

Section: Endemic Pools In Asiamentioning

confidence: 99%

Review of the Global Distribution of Foot-and-Mouth Disease Virus from 2007 to 2014

Brito

Rodrı́guez

Hammond

et al. 2015

Transbound Emerg Dis

223

212

View full text Add to dashboard Cite

Foot-and-mouth disease (FMD) virus affects livestock worldwide. There are seven different serotypes, each with a diversity of topotypes, genetic lineages and strains. Some lineages have different properties that may contribute to sporadic spread beyond their recognized endemic areas. The objective of this study was to review the most significant FMD epidemiological events that took place worldwide between 2007 and 2014. Severe epidemics were caused by FMD virus (FMDV) lineage O/Asia/Mya-98 in Japan and South Korea in 2010, both previously free of disease. In India, where FMD is endemic, the most important event was the re-emergence of lineage O/ME-SA/Ind-2001 in 2008. Notably, this lineage, normally restricted to India, Bangladesh, Nepal and Bhutan, was also found in Saudi Arabia and Libya in 2013 and has caused several outbreaks in Tunisia and Algeria in 2014-2015. In January 2011, FMDV-positive wild boars were found in Bulgaria, where the disease last occurred in 1996, followed by 12 outbreaks in livestock infected with FMDV O/ME-SA/PanAsia2. In 2012, FMDV SAT2 caused outbreaks in Egypt and the Palestinian Autonomous Territories. Another significant event was the emergence of FMDV Asia1 Sindh-08 in the Middle East. In South America, one outbreak of FMDV serotype O, topotype Euro-SA was reported in Paraguay in 2011, which was recognized as FMD-free with vaccination at the time. Lessons learned from past events, point out the need for an integrated strategy that comprises coordinated global and regional efforts for FMDV control and surveillance. Specific local characteristics related to host, environment and virus that condition FMD occurrence should be carefully considered and incorporated to adapt appropriate strategies into local plans. In this review, we compiled relevant epidemiological FMD events to provide a global overview of the current situation. We further discussed current challenges present in different FMD areas.

show abstract

“…In fact, Valdazo-González et al (2013) described an FMDV isolate with a 70-nt deletion in the S fragment located at positions 148–217 of O/HKN/15/2010. Serotype A isolates found in Argentina in 1959 and 1961 ( Carrillo et al, 2005 ), serotype C isolate from the United Kingdom ( Carrillo et al, 2005 ), and serotype A viruses from India found in 2009 ( Subramaniam et al, 2011 ), all have deletions in the S fragment upper-loop, yet they remain infectious. This evidence strongly suggests that the S fragment of the 5′-UTR can tolerate some deletions without compromising pathogenicity.…”

Section: ′- and 3′-viral Utr Rnas Influence The Course Of Infectionmentioning

confidence: 99%

The Roles of Picornavirus Untranslated Regions in Infection and Innate Immunity

2018

View full text Add to dashboard Cite

Viral genomes have evolved to maximize their potential of overcoming host defense mechanisms and to induce a variety of disease syndromes. Structurally, a genome of a virus consists of coding and noncoding regions, and both have been shown to contribute to initiation and progression of disease. Accumulated work in picornaviruses has stressed out the importance of the noncoding RNAs, or untranslated 5′- and 3′-regions (UTRs), in both replication and translation of viral genomes. Unsurprisingly, defects in these processes have been reported to cause viral attenuation and affect viral pathogenicity. However, substantial evidence suggests that these untranslated RNAs may influence the outcome of the host innate immune response. This review discusses the involvement of 5′- and 3′-terminus UTRs in induction and regulation of host immunity and its consequences for viral life cycle and virulence.

show abstract

Comparative complete genome analysis of Indian type A foot-and-mouth disease virus field isolates

Cited by 10 publications

References 43 publications

Multiple introductions of serotype O foot-and-mouth disease viruses into East Asia in 2010–2011

Multiple introductions of serotype O foot-and-mouth disease viruses into East Asia in 2010–2011

Review of the Global Distribution of Foot-and-Mouth Disease Virus from 2007 to 2014

The Roles of Picornavirus Untranslated Regions in Infection and Innate Immunity

Contact Info

Product

Resources

About