Comparative cytological and histological assessment of 828 primary soft tissue and bone lesions, and proposal for a system for reporting soft tissue cytopathology

Koster, Jan De; Ghanei, Iman; Domanski, Henryk A.

doi:10.1111/cyt.12914

Cited by 22 publications

(35 citation statements)

References 32 publications

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“…64 • Soft tissue and bone tumors: FNAB provides valuable information to the clinician for the diagnosis of soft tissue 65 and bone lesions. 66 To avoid time-consuming and costly investigations, FNAB can be used as the initial diagnostic method to triage cases for more expensive radiologic examinations, laboratory tests, and surgical biopsies that are frequently not available or expensive options in LMICs. 67 It is an already widely accepted diagnostic procedure and when used with CNB as required, is gradually replacing open biopsy especially for the initial investigation of deepseated lesions.…”

Section: Cytopathology Is a Screening And Diagnostic Toolmentioning

confidence: 99%

Importance of Cytopathologic Diagnosis in Early Cancer Diagnosis in Resource-Constrained Countries

Yadav¹,

Cree

Field

et al. 2022

JCO Global Oncology

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PURPOSE The rising cancer burden in low- and middle-income countries (LMICs) stresses already weak health care systems and poses unique challenges. In resource-constrained LMICs and in circumstances where most patients must pay out of pocket for diagnostic tests, these may not be available or affordable for many. Cytopathology provides a simple, inexpensive, standardized, and low-technology diagnostic procedure that is increasingly used as an effective tool to address the hurdles faced in cancer control programs in LMICs. This review explores the potential role of cytopathology in LMICs in reducing the cancer burden. METHODS This review studied the existing literature across the globe regarding the utilization of cytopathology as a diagnostic or screening tool for various types of malignancies as well as its advantages and disadvantages, depending on the local situation. RESULTS Apart from the usefulness of cytopathology, this review also sheds light on the barriers to using cytopathology in LMICs. Most recently, SARS-CoV-2 has produced several unique challenges for cytopathology. These are being met with innovative measures to combat the effects of the pandemic and ensure the safe delivery of essential cytopathology services. CONCLUSION The usefulness of cytopathologic techniques has been demonstrated via various studies, even during the recent pandemic. If cytology is to be used appropriately, the focus needs to be on integrating it into the national cancer screening and diagnostic programs as well as providing well-trained human resources.

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Section: Cytopathology Is a Screening And Diagnostic Toolmentioning

confidence: 99%

Importance of Cytopathologic Diagnosis in Early Cancer Diagnosis in Resource-Constrained Countries

Yadav¹,

Cree

Field

et al. 2022

JCO Global Oncology

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“…In our series, cases 5 and 7 showed fibrosis score 3‐4, and FNAC was less cellular and mainly represented by naked nuclei as occurred in other experiences 13 , 17 . Specimen cellularity may be variable, ranging from scant to abundant on FNAC samples 7‐20 and the presence of naked nuclei may depend on the fibrosis associated with the tumour 2 , 29 . Therefore, when smears are poorly cellular, attention should be paid to the finely granular background containing few whole cells, which may be the only features to suggest GCT.…”

Section: Discussionmentioning

confidence: 62%

“…Females are twice as likely to develop GCT; the peak of incidence occurs between the fourth and the sixth decade 2 . Typical GCT clinical presentation includes slow‐growing, solitary and painless subcutaneous nodules that have a benign prognosis, but may be recurring 2 , 3 , 19 , 25 , 26 . Most GCTs are benign, although some are classified as atypical, 2 , 3 , 25 , 26 and roughly 30 malignant GCT have been reported in the literature 2 , 25 , 27 .…”

Section: Discussionmentioning

confidence: 99%

“…As far as the non‐invasive tumour evaluation concerns, magnetic resonance imaging is the gold standard for the radiological assessment of GCTs. FNAC is now a valid and accurate means in the preoperative evaluation of mesenchymal tumours 19‐21 . FNAC features of GCT may be sufficient, in typical cases, for an accurate FNAC diagnosis 7 , 8 , 10‐12 , 14 , 15 , 18 .…”

Section: Discussionmentioning

confidence: 99%

“…Fine needle aspiration cytology (FNAC) features of GCT have been described 2‐21 but, even though GCT may arise in different sites, FNAC reports mainly account for GCT from specific sites that are more frequently targeted by FNAC (ie, breast, thyroid, skin) 2‐21 . GCT cytological features and diagnostic criteria are well known and sufficiently typical to suggest the FNAC diagnosis 2‐20 . Nonetheless, in some cases, cytological features may be less specific and the FNAC diagnosis of GCT may be difficult or impossible 11 , 13 , 17 .…”

Section: Introductionmentioning

confidence: 99%

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Atypical cytological presentation of granular cell tumour: Tumour‐associated fibrosis may affect fine‐needle aspiration cytology accuracy

Vitagliano¹,

Montella

Cozzolino

et al. 2020

Cytopathology

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The cytological features of granular cell tumour (GCT) are generally quite typical but, in some cases, the fine needle aspiration cytology (FNAC) diagnosis of GCT may be difficult or impossible because of unusual sites of onset or equivocal cytological features. In this report, two GCTs with atypical FNAC features are described in order to investigate the causes and provide possible diagnostic tips. From a series of nine histologically proven GCTs, two inconclusive FNAC cases were retrieved. Smears were poorly cellular showing isolated naked nuclei, anisonucleosis, granular chromatin and occasional small nucleoli. The background was finely granular in one case. Histological controls of these cases revealed marked fibrosis. Tumour‐associated fibrosis in GCT is variable and does not seem to influence clinical behaviour but it influences the harvest and the integrity of granular cells collected by FNAC. When GCT smears are poorly cellular, attention should be paid to the granular background and to the few granular cells, if any, as they might be the only features to suggest a GCT.

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Pleomorphic liposarcoma: A clinicopathologic study of 20 FNA cases

Wakely

Wangsiricharoen

Ali

2022

Cancer Cytopathology

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BACKGROUND Pleomorphic liposarcoma (PLPS) is the least common but most aggressive of all forms of liposarcoma (LPS). Its diagnosis relies on the recognition of pleomorphic lipoblasts (PLBs), whose numbers vary considerably. Because few large fine‐needle aspiration (FNA) biopsy studies exist, the authors review their experience with PLPS. METHODS The authors’ cytopathology files were searched for PLPS with histopathologic verification. FNA biopsy smears were performed via standard techniques. RESULTS Twenty cases from 20 patients (male/female ratio, 2.3/1; age range, 22‐77 years; mean age, 58 years) met the inclusion criteria. All had tissue confirmation. Biopsy sites included the following: thigh (11 [55%]), upper extremity (4 [20%]), axilla (2 [10%]), neck (1 [5%]), chest wall (1 [5%]), and mediastinum (1 [5%]). Aspirates were from primary (17 [85%]), locally recurrent (2 [10%]), and metastatic neoplasms (1 [5%]). The FNA diagnoses were PLPS (10 [50%]), myxofibrosarcoma (4 [20%]), LPS (2 [10%]), sarcoma (2 [10%]), and high‐grade malignant neoplasm (2 [10%]). Smears showed thick cell clusters and dissociated single forms. Pleomorphic, epithelioid, and bizarre cell/nuclear shapes were common. PLBs were absent, rare, or unnoticed in 45%. In 25%, smears dominated by myxoid stroma were diagnosed as high‐grade myxofibrosarcoma or myxoid LPS. Ancillary testing performed in 5 cases had limited diagnostic efficacy. CONCLUSIONS FNA biopsy of PLPS, although able to successfully recognize malignancy, suffers from a sampling bias due to an inability to capture or recognize PLBs in a significant proportion of cases secondary to the heterogeneous composition of this neoplasm.;

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Comparative cytological and histological assessment of 828 primary soft tissue and bone lesions, and proposal for a system for reporting soft tissue cytopathology

Cited by 22 publications

References 32 publications

Importance of Cytopathologic Diagnosis in Early Cancer Diagnosis in Resource-Constrained Countries

Importance of Cytopathologic Diagnosis in Early Cancer Diagnosis in Resource-Constrained Countries

Atypical cytological presentation of granular cell tumour: Tumour‐associated fibrosis may affect fine‐needle aspiration cytology accuracy

Pleomorphic liposarcoma: A clinicopathologic study of 20 FNA cases

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