Comparative cytotoxicity of deoxynivalenol, nivalenol, their acetylated derivatives and de-epoxy metabolites

Comparative study of cytotoxicity and oxidative stress induced by deoxynivalenol, zearalenone or fumonisin B1 in human intestinal cell line Caco-2

“…The choice of toxin concentrations to assess cellular macromolecules syntheses inhibition was made on the basis of concentrations that reduced cells viability as determined by neutral red uptake and/or by the reduction of tetrazolium salt (MTT test) by mitochondria. Literature data on inhibitory concentrations in other cell lines have also taken into account (Mobio et al, 2000a;Ouanes et al, 2003;Seefelder et al, 2003;Sundstol Eriksen et al, 2004;Minervini et al, 2004).…”

Modified Fusarium mycotoxins unmasked: From occurrence in cereals to animal and human excretion

“…Sundstol Eriksen et al focussed on DNA inhibition in Swiss mouse 3T3 fibroblasts, and revealed analogous results (Sundstol Eriksen et al, 2004). The last study included the main in vivo metabolite deepoxy-deoxynivalenol (DOM-1).…”

“…Sundstol Eriksen et al showed that FUS-X was approximately 1.5 times more cytotoxic as NIV for mouse fibroblasts (Sundstol Eriksen et al, 2004). Similar results were obtained by Visconti et al, who found that for two cultured human cell lines, K-562 and MIN-GL1, FUS-X showed a 50% cytotoxic dose (CD50) of 0.18 and 0.42 μM respectively, whereas the CD50 values for NIV were 0.64 and 0.96 μM, respectively (Visconti et al, 1991).…”

Concentrations of ergosterol and trichothecenes in the grains of three Triticum species

“…NIV levels were very high in excess of 366 μg/kg. This metabolite is characterised by higher cytotoxicity than DON (Fornelli et al 2004;Sundstøl Eriksen et al 2004), therefore, high NIV concentrations in the grain of cv. Komnata pose a high risk, especially if accompanied by the presence of FX and type A trichothecenes which are marked by high zootoxicity (Ueno 1977).…”