Comparative diagnostic test evaluation of serum procalcitonin and C-reactive protein in suspected bloodstream infections in children with cancer

Nath, Swapna R.; Jayapalan, Sabeena; Nair, Harikumaran; Kusumakumary, P; Prema, NS; Priyakumari, T.; Rajamohanan, K

doi:10.1099/jmm.0.000478

Cited by 14 publications

(11 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results were confirmed by other working groups in non-neutropenic cancer patients with SIRS or in FN patients with or without proven infection [45,46]. However, procalcitonin (PCT) and lipopolysaccharide-binding protein (LBP) presented a promising performance for identifying microbiologically confirmed bacteraemia, which was recently also observed in other neutropenia settings, including paediatric patients [47][48][49]. Presepsin (sCD14) might be used in addition to PCT to detect bacteraemia in these patients, which might have a better discriminatory capacity [49].…”

Section: Sepsis Biomarkers In Neutropenic Systemic Inflammatory Resposupporting

confidence: 85%

Research update for articles published in EJCI in 2015

et al. 2017

View full text Add to dashboard Cite

Section: Sepsis Biomarkers In Neutropenic Systemic Inflammatory Resposupporting

confidence: 85%

Research update for articles published in EJCI in 2015

et al. 2017

View full text Add to dashboard Cite

“…One study evaluated the use of serum CRP and PCT levels in children with cancer, with PCT found to be a better marker than CPR for excluding bloodstream infections (AUC was 0.751 for PCT and 0.638 for CRP). [ 21 ] Another study suggested that PCT was superior to CRP for predicting bacteremia in 92 patients with suspected sepsis (AUC was 0.876 for PCT and 0.602 for CRP). [ 22 ] Significant differences in PCT and CRP levels have also been observed between patients with positive and negative blood cultures (AUC was 0.720 for PCT and 0.558 for CRP), indicating that PCT was also superior to CRP for these patients.…”

Section: Discussionmentioning

confidence: 99%

Role of C-reactive protein and procalcitonin in discriminating between infectious fever and tumor fever in non-neutropenic lung cancer patients

Zhao

et al. 2018

Medicine

View full text Add to dashboard Cite

This study assessed whether C-reactive protein (CRP) and procalcitonin (PCT) levels can discriminate between infectious fever and tumor fever (TF) in non-neutropenic patients with nonsmall cell lung cancer (NSCLC).This retrospective clinical study included 96 adults with NSCLC who were admitted to the Third Hospital of Hebei Medical University between July 2015 and July 2017. Febrile, non-neutropenic patients were enrolled. CRP and PCT levels, neutrophil count, and antimicrobial response were evaluated.This study included 26 patients with TF, 49 with localized bacterial infection (LBI), and 21 with bloodstream infection (BSI). CRP levels in BSI were significantly higher than in TF (P < .05) and LBI (P < .05). No statistically significant difference was found between patients with TF and LBI (P > .05). PCT levels were significantly higher in BSI and LBI than in TF (P < .05). CRP and PCT levels in patients with stage IV disease were significantly higher than in those with stage II to III disease (P < .05). CRP and PCT levels declined significantly in patients with BSI who were responding to antimicrobials (P < .05).Compared with CRP levels, PCT levels can discriminate between TF and infectious fever more accurately. PCT and CRP levels may predict different stages of lung cancer.

show abstract

“…Procalcitonin (PCT) is an inactive propeptide substance of calcitonin. As a systemic inflammatory reaction indicator, it is superior to other inflammatory indicators in the judgement of bacterial infection 11–13 . Existing studies have shown that its concentration is not susceptible to the impacts of immunodeficiency and use of corticosteroids 14,15 , but whether it is susceptible to tumour factors remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic value of procalcitonin, C-reactive protein and lactate dehydrogenase in paediatric malignant solid tumour concurrent with infection and tumour progression

Li¹,

Zhang²,

Hu³

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Infection is a fatal complication in cancer patients that sometimes is not distinguished from tumour progression. We compared the diagnostic value of procalcitonin (PCT), C-reactive protein (CRP) and lactate dehydrogenase (LDH) in paediatric malignant solid tumour concurrent with infection and tumour progression. The 152 children enrolled were divided into infection and control groups. Each group was divided further into stable and progression groups. An intergroup comparison was made in terms of serum PCT, CRP and LDH in all children. PCT, CRP and LDH levels were significantly higher in the infection than in the control groups ( P < 0.05). Among the controls, PCT, CRP and LDH levels were significantly higher in the progression than in the stable groups ( P < 0.05). In diagnosing infection, the sensitivity and specificity of PCT and CRP at the cutoff values of 0.296 ng/mL and 28.13 mg/L were relatively better than those at 0.5 ng/mL and 10 mg/L, respectively. LDH had the highest correlation with tumour progression, whereas PCT had the lowest (LDH, r = 0.684; CRP, r = 0.570; PCT, r = 0.322). Thus, PCT has the highest value in diagnosing infection and is less susceptible to tumour progression than CRP. LDH has obvious advantages in judging tumour progression.

show abstract

Comparative diagnostic test evaluation of serum procalcitonin and C-reactive protein in suspected bloodstream infections in children with cancer

Cited by 14 publications

References 19 publications

Research update for articles published in EJCI in 2015

Research update for articles published in EJCI in 2015

Role of C-reactive protein and procalcitonin in discriminating between infectious fever and tumor fever in non-neutropenic lung cancer patients

Diagnostic value of procalcitonin, C-reactive protein and lactate dehydrogenase in paediatric malignant solid tumour concurrent with infection and tumour progression

Contact Info

Product

Resources

About