Comparative disposition kinetics of ofloxacin following a single i.m. and s.c. administration in neonatal calves

Gaur, Ashok; Sk, Garg; Saini, S. S.

doi:10.1111/j.1365-2885.2005.00687.x

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…, 2004). Although the PK of other fluoroquinolones has been investigated previously (Dumka & Srivastava, 2006; Aliabadi & Lees, 2002, 2003; Gaur et al. , 2005;McKellar et al.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics and pharmacokinetic/pharmacodynamic integration of orbifloxacin in Korean Hanwoo cattle

Lee

Hwang

Park

et al. 2009

Vet Pharm & Therapeutics

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The pharmacokinetics and pharmacodynamics of orbifloxacin were studied in six clinically healthy Hanwoo cows after intravenous (i.v.) and intramuscular (i.m.) administration at a dose of 3 mg/kg. Orbifloxacin concentrations were determined by high performance liquid chromatography with fluorescence detection. Steady-state volume of distribution and clearance of orbifloxacin after i.v. administration were 0.92 L/kg and 0.24 L/h x kg, respectively. Following i.m. administration, a slow and complete absorption with absolute bioavailability of 101.4%, and a maximum concentration (C(max)) of 1.17 microg/mL at 1.04 h were observed. The in vitro serum protein binding was 14.76%. The in vitro antibacterial activity of orbifloxacin against a pathogenic strain of Mannheimia haemolytica (M. haemolytica), Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) was determined. The ex vivo activity of orbifloxacin against M. haemolytica strain was also determined, and these data were integrated with the ex vivo bacterial counts to establish AUC(24h)/MIC values producing bacteriostatic action, bactericidal action and elimination of bacteria. Mean values were 32.7, 51.6 and 102.6 h, respectively. From these data, we predict that orbifloxacin, when administered i.m. at a dosage of 2.5-5 mg/kg once a day, would be effective against bovine pathogens, such as M. haemolytica. Additional studies may be needed to confirm its efficacy in a clinical setting, and to evaluate the penetration of the drug in diseased tissues.

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“…, 2004). Although the PK of other fluoroquinolones has been investigated previously (Dumka & Srivastava, 2006; Aliabadi & Lees, 2002, 2003; Gaur et al. , 2005;McKellar et al.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics and pharmacokinetic/pharmacodynamic integration of orbifloxacin in Korean Hanwoo cattle

Lee

Hwang

Park

et al. 2009

Vet Pharm & Therapeutics

View full text Add to dashboard Cite

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Pharmacokinetics and bioavailability of ofloxacin following single intramuscular and subcutaneous administration in goats

YADAV,

GARG

2016

Indian J of Anim Sci

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Comparative disposition kinetics of ofloxacin following intramuscular (i.m.) and subcutaneous (s.c.) administration was studied in goats @ 10 mg/kg. Ofloxacin was determined by HPLC method and kinetic parameters using a software. Appreciable plasma concentrations were observed within 2.5 min of drug administration and peaked at 1 h. t1/2ka and t1/2β values were 13.59 and 78.41 min after i.m. administration while 17.89 and 103.59 min after s.c. administration and the corresponding bioavailability values were 75.43±5.00 and 102.07±7.00 %. Ofloxacin may be adiministered to goat @10 mg/kg at 12 h interval by s.c. route.

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Comparative disposition kinetics of ofloxacin following a single i.m. and s.c. administration in neonatal calves

Cited by 2 publications

References 16 publications

Pharmacokinetics and pharmacokinetic/pharmacodynamic integration of orbifloxacin in Korean Hanwoo cattle

Pharmacokinetics and pharmacokinetic/pharmacodynamic integration of orbifloxacin in Korean Hanwoo cattle

Pharmacokinetics and bioavailability of ofloxacin following single intramuscular and subcutaneous administration in goats

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