Comparative dosimetrical analysis of intensity-modulated arc therapy, CyberKnife therapy and image-guided interstitial HDR and LDR brachytherapy of low risk prostate cancer

Abstract

background:The objective of the study was to dosimetrically compare the intensity-modulated-arc-therapy (IMaT), cyber-Knife therapy (cK), single fraction interstitial high-dose-rate (hDr) and low-dose-rate (LDr) brachytherapy (BT) in low-risk prostate cancer.Materials and methods: Treatment plans of ten patients treated with cK were selected and additional plans using IMaT, hDr and LDr BT were created on the same cT images. The prescribed dose was 2.5/70 Gy in IMaT, 8/40 Gy in cK, 21 Gy in hDr and 145 Gy in LDr BT to the prostate gland. eQD2 dose-volume parameters were calculated for each technique and compared. results: eQD2 total dose of the prostate was significantly lower with IMaT and cK than with hDr and LDr BT, D90 was 79.5 Gy, 116.4 Gy, 169.2 Gy and 157.9 Gy (p < 0.001). however, teletherapy plans were more conformal than BT, cOIN was 0.84, 0.82, 0.76 and 0.76 (p < 0.001), respectively. The D 2 to the rectum and bladder were lower with hDr BT than

A comparison between high dose rate brachytherapy and stereotactic body radiotherapy boost after elective pelvic irradiation for high and very high-risk prostate cancer

“…The dosimetric analysis gives some explanations to the observed differences: D 0.1cm 3 and D 2cm 3 for anterior rectal wall was about 22%-28% higher with SBRT boost. These dosimetric differences in the dose to the anterior rectal wall were already mentioned in the literature [17][18][19]. In particular, in the study of Frohlich et al [19], D 2cm 3 to the rectum was 1.8 higher with SBRT compared to HDRB.…”

“…These dosimetric differences in the dose to the anterior rectal wall were already mentioned in the literature [17][18][19]. In particular, in the study of Frohlich et al [19], D 2cm 3 to the rectum was 1.8 higher with SBRT compared to HDRB. Literature analysis clearly demonstrated that these differences transformed into important clinical consequences.…”

The value of brachytherapy in the age of advanced external beam radiotherapy: a review of the literature in terms of dosimetry

“…Fröhlich et al. [ 60 ] performed a comparison of two BT (LDR and HDR) and two EBRT (VMAT, CK) techniques using the CT images sets of 10 patients treated with CK. EQD2 doses were calculated and compared.…”

“…From these results, the authors conclude the superiority of HDR-BT for rectal and bladder dosimetry. Fröhlich et al [60] performed a comparison of two BT (LDR and HDR) and two EBRT (VMAT, CK) techniques using the CT images sets of 10 patients treated with CK. EQD2 doses were calculated and compared.…”