Comparative effect of cimetidine and ranitidine on prolactin secretion

Nelis, G. F.; Meene, J. G. Van de

doi:10.1136/pgmj.56.657.478

Cited by 37 publications

(4 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings supported the observations of Bateson et al, 18 Burland et al, 4 Carlson et al, 19 Winter et al, 20 Penden et al 21 and Nelis et al 6 The prolactin levels in pretreated rabbits were found insignificantly raised on statistical analysis (Diagram).…”

Section: Discussionsupporting

confidence: 85%

“…4,5 The rise in prolactin secretion after IV Cimetidine is widely agreed, but the mechanism of action is still unclear. 6 Even though there were many reports of raised prolactin level with many side effects, 7 only a few case of raised prolactin level is related with Cimetidine administration. 8 But the effect of the newer H2 receptor antagonists Ranitidine does not produce the rise in serum prolactin level even after IV Ranitidine.…”

mentioning

confidence: 99%

See 1 more Smart Citation

To Study the Effect of the Parenteral Administration of Cimetidine on Serum Prolactin Level in Experimental Animals

Singh¹,

S²

2018

jemds

View full text Add to dashboard Cite

BACKGROUND Among the H2 receptor antagonists, Cimetidine promotes healing of peptic ulcer and reduces ulcer pain, but produces a few significant side effects-gynaecomastia, galactorrhoea, etc. H1 antagonists and H2 agonists suppress prolactin release in suckled mother, while H1 agonists and H2 antagonists release prolactin in non-suckled mother. 2 The relationship between H2 receptor inhibitory and H1 receptor stimulant for the raise or decrease of serum prolactin level and also for involvement of third ventricle in hypothalamus area is to be investigated. MATERIALS AND METHODSThe present study was to ascertain the site of action of Cimetidine for the raised serum prolactin, whether peripheral action or central action. Therefore, the route of administration of the H2 receptor antagonist Cimetidine was chosen as intravenous and intracerebroventricular respectively. Finally, serum prolactin level was estimated by drawing blood from the ear vein of the experimental animal (Rabbit) every 15 mins, 30 mins and 45 mins respectively. Then, serum prolactin levels were compared and analysed statistically. RESULTSThe serum prolactin level was found significantly raised at 15 mins (p < 0.05) and 30 mins (p < 0.001) after the IV Cimetidine. However, there is no significant difference between IV Cimetidine and ICV Cimetidine pre-treated group as Diphenhydramine blocked H1 receptor. CONCLUSIONSo, it can be concluded that Cimetidine causes raise in serum prolactin level due to its peripheral and central action. KEYWORDSProlactin, Cimetidine, Diphenhydramine, Intracerebroventricular, Radioimmunoassay, Rabbits. HOW TO CITE THIS ARTICLE: Singh OJ, Losica SRK. To study the effect of the parenteral administration of cimetidine on serum prolactin level in experimental animals. J. Evolution Med. Dent. Sci. 2018;7(13):1599-1601, DOI: 10.14260/jemds/2018/362 BACKGROUND The involvement of histamine in controlling of gastric acid secretion was supported with the discovery of specific inhibitor of H2 receptor on parietal cells. The role of histamine and its pharmacological importance has increasingly come to light after which the characterisation of H2 receptor antagonists-Burimamide, Metiamide and Cimetidine. 1 Among the H2 receptor antagonists, Cimetidine promotes healing of peptic ulcer and reduces ulcer pain, but produces a few significant side effects-gynaecomastia, galactorrhoea, etc. H1 antagonists and H2 agonists suppress prolactin release in suckled mother, while H1 agonists and H2 antagonists release prolactin in non-suckled mother. 2 The relationship between H2 receptor inhibitory and H1 receptor stimulant for the raise or decrease of serum prolactin level and also for involvement of third ventricle in hypothalamus area is to be investigated. 3 'Financial or Other Competing Interest': None. Submission 19-01-2018, Peer Review 12-03-2018, Acceptance 18-03-2018, Published 26-03-2018. Corresponding Author: Dr. S. Losica R. K, Quarter No.5, Phase II, Transit Quarter, Sanjenthong, Imphal-795001, Manipur. E-mail: lul....

show abstract

Section: Discussionsupporting

confidence: 85%

mentioning

confidence: 99%

To Study the Effect of the Parenteral Administration of Cimetidine on Serum Prolactin Level in Experimental Animals

Singh¹,

S²

2018

jemds

View full text Add to dashboard Cite

show abstract

“…The anti-andro¬ genic effect of cimetidine therefore appears to be an inherent property of this compound and is not related to its histame H2-receptor blocking activity. Similarly, Nelis & Van de Meene (1980b) have shown that while intravenously administered cime¬ tidine stimulates prolactin secretion, ranitidine does not, thus providing another example of dis¬ sociation between histamine H2-receptor blocking activity and the endocrine effects of these drugs.…”

Section: Discussionmentioning

confidence: 99%

Effects of two histamine H2-receptor blocking drugs on basal levels of gonadotrophins, prolactin, testosterone and oestradiol-17β during treatment of duodenal ulcer in male patients

Peden

Boyd

Browning

et al. 1981

Acta Endocrinologica

View full text Add to dashboard Cite

In a study of 51 male patients with duodenal ulcer, treatment with cimetidine was accompanied by an increase in basal levels of serum testosterone. Treatment with ranitidine, a new histamine H2-receptor antagonist, produced no such effect. It is concluded that cimetidine has antiandrogenic activity in man which is separate from the histamine H2-receptor blocking activity. Sexual dysfunction (Peden et al. 1979a; Wolfe 1979) and lowered sperm counts (Van Thiel et al. 1979) have been reported in man during treatment with cimetidine. Cimetidine has also been shown to exert antiandrogenic effects in animals (Leslie 8c Walker 1977; Winters et al. 1979) but ranitidine, a powerful new histamine H2-receptor antagonist apparently does not (Usadel 1979). We have there¬ fore compared the effects of these two drugs on basal levels of gonadotrophins, prolactin (Prl), tes¬ tosterone and oestradiol-17ß (Oe2) in male patients with duodenal ulcer (DU). Materials and Methods (a) PatientsThree groups were studied.(i) Thirty-three patients (mean age 39.5 years ± 4.5 SEM) with endoscopically proven duodenal ulcer were investigated. Twenty-two patients received cimetidine 1000 mg/day and were studied before and at the end of a 4 week course of treatment. The other 11 patients received cimetidine 800 mg/day in a subsequent double blind therapeutic trial of cimetidine against ranitidine (Peden et al., in press) and were studied before, after 2 weeks and at the end of their 4 week course of treatment.Twenty-eight of these patients achieved ulcer healing and 31 became asymptomatic.(ii) Eighteen patients (mean age 41.3 years ± 3.6 sem) received ranitidine and were studied before, after 2 weeks and at the end of a 4 week course of treatment. Six patients received a dosage of 320 mg/day in the double blind trial mentioned above, while 12 patients received 300 mg/day in a further open evaluation of a twice-daily dosage regime (Peden et al., in press). Sixteen of these patients achieved ulcer healing and all became asymp¬ tomatic.(iii) Nineteen patients who had been treated contin¬ uously with cimetidine 1000 mg/day and 2 patients

show abstract

“…Cimetidine has been shown to affect the hepatic metabolism of a number of drugs including antipyrine and aminopyrine (Staiger et al, 1980;Henry et al, 1980), warfarin and phenindione (Hetzel, Birkett and Miners, 1979), chlordiazepoxide and diazepam (Patwardham et al, 1980), phenytoin (Hetzel et al, 1981) and propranolol (Heagerty et al, 1981). In addition, cimetidine produces an elevation of serum prolactin levels after intravenous injection (Nelis and Van de Meene, 1980;Kleist et al, 1981). Ranitidine has been reported as showing more prolonged gastric acid suppression than cimetidine in a man with Zollinger-Ellison syndrome in whom gynaecomastia regressed and sexual activity improved when ranitidine was substituted for cimetidine (Mignon et aL, 1980).…”

Section: Discussionmentioning

confidence: 99%

Ranitidine compared with cimetidine in the short-term healing of duodenal ulcer

Lee

Costello

1983

Postgraduate Medical Journal

View full text Add to dashboard Cite

SummaryThe efficacy of ranitidine (150 mg twice daily) and cimetidine (200 mg three times daily and 400 mg at night) in the short-term healing of duodenal ulcer has been assessed in a randomized controlled trial involving 106 patients. There were 3 drop-outs. Fortytwo out of 53 patients (791%) treated with ranitidine had healed ulcers at 4 weeks compared with 37 out of 50 treated with cimetidine (74%). This difference is not significant. At 8 weeks the healing rate for ranitidine (98o) was significantly greater than that for cimetidine (86%) (P<0 05). There was no significant difference in healing rates between men and women and between smokers and non-smokers. Side effects were not a problem with either drug. There were no differences of clinical significance between laboratory values in the two treatment groups, although a minor increase in mean creatinine levels occurred in the cimetidine-treated group.KEY WORDS: ranitidine, cimetidine, duodenal ulcer. IntroductionRanitidine, the second H2 receptor antagonist to be introduced into clinical practice in the United Kingdom, has been shown to have a marked inhibitory effect on gastric acid secretion, greater than that of cimetidine. We report a trial comparing ranitidine and cimetidine in the short-term healing of duodenal ulceration.

show abstract

Comparative effect of cimetidine and ranitidine on prolactin secretion

Cited by 37 publications

References 7 publications

To Study the Effect of the Parenteral Administration of Cimetidine on Serum Prolactin Level in Experimental Animals

To Study the Effect of the Parenteral Administration of Cimetidine on Serum Prolactin Level in Experimental Animals

Effects of two histamine H2-receptor blocking drugs on basal levels of gonadotrophins, prolactin, testosterone and oestradiol-17β during treatment of duodenal ulcer in male patients

Ranitidine compared with cimetidine in the short-term healing of duodenal ulcer

Contact Info

Product

Resources

About