Comparative Effect of Intravenous Administration of Medetomidine, Tramadol, and Medetomidine/Tramadol Combination on Intraocular Pressure (IOP) in Clinically Healthy Donkeys (Equus asinus)

Various ophthalmic disorders (conjunctivitis, corneal wounds, keratitis) have been reported in donkeys. There are no studies on the effect of medetomidine or tramadol on Schirmer tear test (STT) readings in donkeys. This prospective study investigated changes in STT readings in 24 clinically healthy donkeys (Equus asinus) (14 geldings and 10 mares) treated with commonly used doses of medetomidine hydrochloride and tramadol hydrochloride as mono- or combined therapy. Analgesia, sedation, ataxia, and STT readings were measured before treatment (baseline) and at different periods after administration (5–120 min) of the specific drug in each group. Tramadol monotherapy induced a mild analgesic effect (score 1) at 10 min post-administration. All treated donkeys exhibited mild to moderate ataxia. Medetomidine alone or in combination with tramadol induced a significant decrease (P<0.05) in the STT readings in both right and left eyes at 5, 15, 30, and 60 min relative to baseline, and the lowest values were observed 60 min after drug administration in both groups. Intravenous administration of medetomidine alone or in combination with tramadol induced a significant reduction in STT readings in clinically healthy donkeys. Therefore, in donkeys, the ocular surface treated with these sedatives should be carefully examined and adequately covered by an artificial tear solution or ophthalmic gel.

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Donkey Heart Rate and Heart Rate Variability: A Scoping Review

Santis

Seganfreddo

Greco

et al. 2023

Animals

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Heart rate (HR) and heart rate variability (HRV) are commonly used physiological measures in animals. While several studies exist on horse HRV, less information is available for donkeys. This scoping review aims to understand the extent and type of published evidence on donkey HR and HRV, their clinical and research applications, the devices used, and the analysis performed. Only quantitative primary studies published in English were considered. Four different databases were queried through the Web of Science platform, with additional evidence identified by citation chasing. After a two-stage screening phase, data were extracted considering study and population characteristics, information on HR/HRV analysis, and applications. The majority of the 87 included articles (about 80%) concerned a sample size of up to 20 individuals and were published since 2011 (about 65%). Forty-one articles employed an electronic device for signal acquisition (mainly electrocardiographs and heart rate monitors), yet only two articles reported HRV parameters. The literature on donkey HRV is lacking, and this gap can be filled by gaining knowledge on donkey characteristics and finding useful tools for welfare assessment. Comparison with what is known about the horse allows a discussion of the technical and interpretative difficulties that can be encountered with donkeys.

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Comparative Effect of Intravenous Administration of Medetomidine, Tramadol, and Medetomidine/Tramadol Combination on Intraocular Pressure (IOP) in Clinically Healthy Donkeys (Equus asinus)

Cited by 3 publications

References 25 publications

Effects of medetomidine and dexmedetomidine on intraocular pressure, pupil size, and tear secretion in clinically normal Ghezel sheep

Effects of medetomidine and dexmedetomidine on intraocular pressure, pupil size, and tear secretion in clinically normal Ghezel sheep

Comparative evaluation of the intravenous effect of medetomidine, tramadol and medetomidine/tramadol combination on tear production in clinically healthy donkeys (Equus asinus)

Donkey Heart Rate and Heart Rate Variability: A Scoping Review

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