Comparative effectiveness of Biobrane®, RECELL® Autologous skin Cell suspension and Silver dressings in partial thickness paediatric burns: BRACS randomised trial protocol

Bairagi, Anjana; Griffin, Bronwyn; Tyack, Zephanie; Vagenas, Dimitrios; McPhail, Steven; Kimble, Roy

doi:10.1186/s41038-019-0165-0

Cited by 16 publications

(15 citation statements)

References 75 publications

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“…The advances in material sciences have deepened understanding of wound healing and infections and driven the development of new dressings [ 28 ]. Today, a wide variety of dressings are available in the market or have been tested in clinical practice [ 5 , 29 ]. The materials used for dressing include hydrocolloid, polyurethane film, hydrogel, silicon-coated nylon, biosynthetic skin substitute, antimicrobial, fiber, and pads [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Bacterial Cellulose Dressing versus Vaseline Gauze in Partial Thickness Burn Wounds and Skin Graft Donor Sites: A Two-Center Randomized Controlled Clinical Study

Pan

Han

Chen

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. Bacterial cellulose (BC) dressing, which can maintain a moist environment and prevent the invasion of pathogens, has become a competitive dressing material for burn wound treatment. This study was conducted to evaluate the treatment efficacy of a novel China-made BC dressing for the treatment of second-degree burn wounds and skin graft donor sites. Methods. 212 patients with second-degree burn wounds or skin graft donor sites were enrolled from two research centers. They were randomly assigned to the BC dressing group (study group) or the Vaseline gauze (VG) dressing group (control group). Wound conditions were assessed before and after treatment. Dressings were changed according to the condition of the wound bed. Healing rate and healing time were recorded as primary endpoints to evaluate the efficacy of BC dressing against VG dressing. Erythema, swelling, exudation, bleeding, subeschar purulence, and pain were assessed as secondary endpoints. Results. 207 participants completed the trial and their wounds all healed within 28 days. The average healing times for superficial and deep secondary burn wounds and skin graft donor sites in the BC group were 8.12, 15.77, and 10.55 days, respectively. In the VG group, the average healing times for superficial and deep secondary burn wounds and skin graft donor sites were 9.30, 15.27, and 11.19 days, respectively. The healing time of superficial burn wounds in the BC group was statistically shorter than that in the VG group. There was no difference in the frequency of dressing changing between two groups. The BC dressing showed equal efficacy with the VG dressing at all secondary endpoints. Conclusion. The novel BC dressing could be used for the management of second-degree burn wounds and skin graft donor sites. With a shorter healing time in superficial secondary burn wound than that of the VG dressing, the BC dressing showed noninferiority in the treatment of superficial and deep secondary burn wounds and skin graft donor sites versus the VG dressing. This study is registered with the Chinese Clinical Trial Registry (registry number: ChiCTR1800014377 (http://www.chictr.org.cn)).

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Section: Discussionmentioning

confidence: 99%

Evaluation of Bacterial Cellulose Dressing versus Vaseline Gauze in Partial Thickness Burn Wounds and Skin Graft Donor Sites: A Two-Center Randomized Controlled Clinical Study

Pan

Han

Chen

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Prolonged healing time does not only result in an increased burden for the patient and costs for the health system, but also raises the probability of hypertrophic scarring. 3,8,15,18,19,30 In this study, we tested a new promising material based on nanocellulose to treat IIa degree burns in children aged 5 months to 16 years. Over the past years, many research groups focused on defining characteristics for the optimal dressing for advanced burn wound management.…”

Section: Discussionmentioning

confidence: 99%

“…High stress levels could lead to a dysregulation of biomarkers and thereby to an impairment of the healing process. 12,[19][20][21][22] Even when leaving the dressing in place for 7 days, no adverse events related to the used material had been detected, potentially underlining its high biocompatibility. Additionally, the material we used in our study was easy to handle in clinical practice performing dressing changes.…”

Section: Discussionmentioning

confidence: 99%

“…Providing an optimal healing environment to ensure fast reepithelialisation within 10-14 days to prevent complications such as wound infections and scarring is crucial. 4,8,15,18,19 To keep pain and stress levels in children to a minimum, a dressing which allows infrequent changes should be chosen. Frequent and painful dressing changes may not only cause traumatisation of the child but also disturb the wound healing process.…”

Section: Introductionmentioning

confidence: 99%

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Nanocellulose‐based wound dressing for conservative wound management in children with second‐degree burns

Resch

Staud

Radtke

2021

International Wound Journal

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The initial care of burn wounds and choice of dressing are pivotal to optimally support the healing process. To ensure fast re-epithelialisation within 10-14 days and prevent complications, an optimal healing environment is essential. An innovative dressing based on nanocellulose was used for the treatment of burns in children. Children (0-16 years) with clean, partial-thickness burn wounds, 1 to 10% of the total body surface area were included. Complete re-epithelialisation was achieved within 7-17 days, with 13 patients showing re-epithelialised >95% by day 10. Satisfying results concerning time to re-epithelialisation and material handling were obtained. The possibility to leave the dressing on the wounds for 7 days showed a positive effect in the treatment of children, for whom every hospital visit may cause massive stress reactions. The nanocellulose-based dressing is a promising tool in conservative treatment of burns. Reducing the frequency of dressing changes supports a fast and undisturbed recovery; moreover, the dressing provides an optimal moist healing environment. The time to re-epithelialisation is comparable to frequently used materials, and cost reduction effect can be achieved without loss of quality. Possible pain and distress levels are kept to a minimum; therefore, flexibility and compliance of the patients and their parents are enhanced.

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“…2 Instead of surgical treatment, a considerable number of patients prefer to receive conservative treatment. Common conservative treatments for chronic wounds include topical application of growth factor (FGF and EGF), new dressings, 3 platelet-rich plasma, 4 negative pressure wound therapy (NPWT), hyperbaric oxygen, 5 red and blue light irradiation 6,7 and so forth.…”

mentioning

confidence: 99%

The associations between diode laser (810 nm) therapy and chronic wound healing and pain relief: Light into the chronic wound patient's life

Tang

Liu

Chen

et al. 2023

Wound Repair Regeneration

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Chronic wounds have become one of the major issues in medicine today, the treatments for which include dressing changes, negative pressure wound therapy, hyperbaric oxygen, light irradiation, surgery and so forth. Nevertheless, the application of diode lasers in chronic wounds has rarely been reported. This retrospective cohort study aimed to evaluate the therapeutic effect of diode laser (810 nm) irradiation on chronic wounds. Eighty‐nine patients were enrolled in the study. The control group (41 patients) received traditional dressing change therapy, while the diode laser treatment group (48 patients) were patients received additional treatment with diode laser (810 nm) irradiation for 10 min at each dressing change. Wound healing time was compared between two groups, while the pain relief index was creatively introduced to evaluate the effect of relieving wound pain, which was calculated by the difference in pain scores between the first and last dressing changes divided by the number of treatment days. The wound healing time of the diode laser treatment group was 22.71 ± 8.99 days, which was significantly shorter than that of the control group (37.44 ± 23.42 days). The pain relief index of the diode laser treatment group was 0.081 ± 0.055, which was significantly increased compared with that of the control group (0.057 ± 0.033). Our findings suggest that diode laser irradiation has the potential to promote healing in chronic wounds and relieve wound pain.

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Comparative effectiveness of Biobrane®, RECELL® Autologous skin Cell suspension and Silver dressings in partial thickness paediatric burns: BRACS randomised trial protocol

Cited by 16 publications

References 75 publications

Evaluation of Bacterial Cellulose Dressing versus Vaseline Gauze in Partial Thickness Burn Wounds and Skin Graft Donor Sites: A Two-Center Randomized Controlled Clinical Study

Evaluation of Bacterial Cellulose Dressing versus Vaseline Gauze in Partial Thickness Burn Wounds and Skin Graft Donor Sites: A Two-Center Randomized Controlled Clinical Study

Nanocellulose‐based wound dressing for conservative wound management in children with second‐degree burns

The associations between diode laser (810 nm) therapy and chronic wound healing and pain relief: Light into the chronic wound patient's life

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