2019
DOI: 10.1016/j.arthro.2019.06.017
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Comparative Effectiveness of Different Nonsurgical Treatments for Patellar Tendinopathy: A Systematic Review and Network Meta-analysis

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Cited by 42 publications
(51 citation statements)
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“…The mean difference in functional outcome was 13.22 (95% CI (2.37, 24.07)). In the pain scale, the mean difference comparing PRP with control groups was −1.87 (95% CI (−3.28, −0.46)) and showed that leukocyte-rich PRP (LR-PRP) has better functional improvement and pain reduction for patellar tendinitis compared with corticosteroids, treatment ultrasound, autologous blood injection (ABI) or topical glyceryl trinitrate (TGT) compared to control groups [94]. In our meta-analysis, four RCTs were included [6][7][8][9].…”
Section: Discussionmentioning
confidence: 99%
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“…The mean difference in functional outcome was 13.22 (95% CI (2.37, 24.07)). In the pain scale, the mean difference comparing PRP with control groups was −1.87 (95% CI (−3.28, −0.46)) and showed that leukocyte-rich PRP (LR-PRP) has better functional improvement and pain reduction for patellar tendinitis compared with corticosteroids, treatment ultrasound, autologous blood injection (ABI) or topical glyceryl trinitrate (TGT) compared to control groups [94]. In our meta-analysis, four RCTs were included [6][7][8][9].…”
Section: Discussionmentioning
confidence: 99%
“…Life 2020, 10, 94 14 of 42 Figure 13. Forest plot for WOMAC scores comparing single PRP injection versus multiple PRP injections (CI: confidence interval; IV: inverse variance; SD: standard deviation).…”
Section: Osteoarthritismentioning
confidence: 99%
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“…Unlike osteoarthritis, tendinopathies may benefit from increased leukocyte concentrations, which is attributed to the presence of mononuclear cells. Mononuclear cells, particularly monocytes, have been associated with increased cellular metabolism and collagen production (35)(36)(37)(38). In the study by Carr et al, lymphocytes and monocytes were increased using this system, but only lymphocytes reached significance (39).…”
Section: Figure 4 |mentioning
confidence: 92%
“…Generally, it is believed that red blood cells and leukocytes, particularly neutrophils, should be decreased because they are pro-inflammatory, delivering catabolic cytokines like interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) that induce cartilage degeneration in OA (4,5,(31)(32)(33)(34). The ideal concentration of monocytes and lymphocytes is still debatable, but there is increasing evidence that their increased concentration can be beneficial in tissue turnover and collagen synthesis, a potentially desirable effect for tendon and ligament injury (35)(36)(37)(38).…”
Section: Introductionmentioning
confidence: 99%