Comparative effectiveness of East Asian traditional medicine for treatment of idiopathic short stature in children

Lee, Boram; Kwon, Chan-Young; Jang, Soobin

doi:10.1097/md.0000000000022856

Cited by 7 publications

(8 citation statements)

References 14 publications

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“…However, since the descriptions of sexual maturity in the included studies were insufficient, it is difficult for us to predict the effect of sexual maturity on the growth outcomes in these studies. Finally, we planned subgroup analysis according to the treatment period in this study's protocol, 17 but subgroup analysis was not possible due to the low number of included studies. In addition, since none of the included studies were evaluated as having a low risk of bias, sensitivity analysis to investigate the robustness of the meta-analysis results was not possible.…”

Section: Discussionmentioning

confidence: 99%

Comparative effectiveness of East Asian traditional medicine for treatment of idiopathic short stature in children: Systematic review and network meta-analysis

Lee

Kwon

Jang

2022

Integrative Medicine Research

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Background Idiopathic short stature (ISS) is a common problem in children and causes many economic and social burdens. In Asian countries, East Asian traditional medicine (EATM) therapies are widely used for children with ISS. In this study, we compared and ranked various EATM therapies for the treatment of pediatric ISS using network meta-analysis. Methods Randomized controlled trials that evaluated various EATMs for pediatric ISS were found through searching 14 electronic databases. The primary outcome was growth velocity (GV). The comparative effectiveness of the treatments was ranked based on the surface under the cumulative ranking curve (SUCRA) and the risk of bias was assessed. The quality of evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluations approach. Results Fourteen studies comprising 1,066 participants were included. HM plus GH showed statistically significant superiority over other EATM therapies including acupuncture (weighted mean difference (WMD) 3.20 cm, 95% confidence interval (CI) 0.40 to 5.99) and HM (WMD 3.70 cm, 95% CI 1.41 to 5.99) for improving GV per year, although there was no difference compared with GH alone (WMD 1.18 cm, 95% CI -0.27 to 2.63). SUCRA indicated that HM plus GH was the most effective therapy for increasing GV, followed by GH, HM plus acupressure, and HM. No serious adverse events were reported. Conclusion For the treatment of ISS, HM plus GH might have a large beneficial effect and might be a better option than EATM therapies and GH alone. However, more long-term, high-quality trials are warranted to confirm the findings. Protocol registration PROSPERO ( https://www.crd.york.ac.uk/prospero/ ), CRD42020187160.

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Section: Discussionmentioning

confidence: 99%

Comparative effectiveness of East Asian traditional medicine for treatment of idiopathic short stature in children: Systematic review and network meta-analysis

Lee

Kwon

Jang

2022

Integrative Medicine Research

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“…Idiopathic short stature (ISS) accounts for 60%–80% of cases with short stature in children ( Cohen et al, 2008 ). ISS is characterized with a height below the two standard deviations or the third percentile of the normal reference levels for the same ethnic group, gender and age, without chronic systemic, endocrine, nutritional, skeletal diseases or chromosomal abnormalities ( Lee et al, 2020 ). To date, no breakthrough has been made in the field of treatment to improve height in ISS children due to the uncertain etiology.…”

Section: Introductionmentioning

confidence: 99%

Hsa_circ_0008870 suppresses bone formation of growth plate through inhibition of miR-185-3p/ MAPK1 axis in idiopathic short stature

Yuan²,

Li³

et al. 2022

Front. Bioeng. Biotechnol.

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Idiopathic short stature (ISS) is the most common clinical cause of the short stature with an unclear aetiology and a lack of effective treatment. Circular RNAs have been shown to play a significant regulatory role through various signal transduction pathways in a variety of diseases in recent years. However, the role of circular RNAs on ISS is not yet well-understood and requires a special attention. The differentially expressed circular RNAs were screened by microarray chip analysis, and RT-qPCR was used to verify the expression of hsa_circ_0008870 in ISS patients. Subsequently, in vitro and in vivo experiments were conducted to determine the biological functions of hsa_circ_0008870 in ISS. The authors first confirmed that hsa_ circ_0008870 was downregulated in ISS children. Meanwhile, we also observed that the downregulated hsa_circ _0008870 significantly inhibited chondrocyte proliferation and endochondral ossification in vivo and in vitro. Mechanistically, hsa_circ_0008870 regulates MAPK1 expression by sponge miR-185-3p. This mechanism of action was further verified through rescue experiments. Finally, the authors revealed that the silencing of hsa_circ_0008870 induces low expression of MAPK1 by impairing the sponge action of miR-185-3p, thereby inhibiting chondrocyte proliferation, hypertrophy, and endochondral ossification, which results in a short stature phenotype. In addition to these, we also observed an interesting phenomenon that upregulated of miR-185-3p can in turn inhibit the expression of hsa_circ_0008870 in chondrocytes. This suggests that hsa_circ_0008870 could potentially serve as a therapeutic target for the treatment of ISS.

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“…However, complementary and alternative medicine (CAM) treatment is often considered despite the following concerns: reluctance to start artificial hormone therapy at an early age, fear of potential side effects, discomfort of getting an injection every four weeks, and poorer outcomes than expected with regards to the improvement of final adult height [ 11 ]. Traditional Korean medicine (TKM) has been used for the treatment of various diseases and is currently one of the most popular CAM [ 12 ] treatments. ICPP, which accounts for the highest percentage of PP and is free from other identifiable diseases, can benefit from TKM [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Perceptions and Treatment of Precocious Puberty: A Questionnaire Survey among Caregivers in South Korea

Shim

Song

Lee

2022

Evidence-Based Complementary and Alternative Medicine

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This study aims to provide the basis for developing complementary and alternative treatment approaches for precocious puberty (PP) by examining caregivers’ awareness, along with their preferences and expectations from various treatments. It included data collected between July 2019 and March 2020, from 175 caregivers of children who were undergoing or had undergone treatment for PP. The questionnaire comprised 53 questions on the awareness, acquisition of information, perceptions of treatments, and concerns about PP, as well as awareness of habit management (HM) and children’s actual habits. The collected data were analysed using the Chi-square test, t-tests, and one-way analysis of variance. The caregivers responded that PP could be recognized on the basis of breast development (79.8%) in girls and hair and body odor (73.1%) in boys. However, 86.9% of respondents were getting inaccurate information from the Internet. With respect to PP treatment approaches, 16% of respondents hoped to manage PP through conventional treatment (CT), 21.1% preferred traditional Korean medicine (TKM), and 62.3% preferred HM. Expectations of the effectiveness were highest in HM, followed by CT and TKM. Only the TKM group had statistically significant higher expectations than the nontreatment experience group (F = 4.566, p = 0.004 ). The caregivers were concerned about the side effects and high costs of CT. Around 43% of respondents had difficulties with the management of their children’s diet, 64.6% with exercise, and 57.1% with smart device usage. Clinicians should be aware of caregivers’ information acquisition patterns, preferences and expectations of various treatments, and their concerns. Considering these results, clinicians should try to establish more appropriate treatment plans for children with PP.

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Comparative effectiveness of East Asian traditional medicine for treatment of idiopathic short stature in children

Cited by 7 publications

References 14 publications

Comparative effectiveness of East Asian traditional medicine for treatment of idiopathic short stature in children: Systematic review and network meta-analysis

Comparative effectiveness of East Asian traditional medicine for treatment of idiopathic short stature in children: Systematic review and network meta-analysis

Hsa_circ_0008870 suppresses bone formation of growth plate through inhibition of miR-185-3p/ MAPK1 axis in idiopathic short stature

Perceptions and Treatment of Precocious Puberty: A Questionnaire Survey among Caregivers in South Korea

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