Comparative effectiveness of individualised homeopathy and antibiotics in the treatment of bovine clinical mastitis: randomised controlled trial

Keller, Diana; Sundrum, Albert

doi:10.1136/vr.104555

Cited by 19 publications

(14 citation statements)

References 31 publications

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“…These cure rates were comparable to those of placebo (45-47%). The cytological cure level in all three treatment methods were similarly ineffective being 2-21% in antibiotic treated; 0-8% in individualised homeopathy and 3-13% in placebo (Keller & Sundrum, 2018). Even some of the studies have shown a significantly lower cure rate in clinical mastitis with the homeopathy compared to the antibiotic treatment (Williamson & Lacy-Hulbert 2014;Ebert et al 2017).…”

Section: Native Secretory Factorsmentioning

confidence: 98%

Advances in therapeutic and managemental approaches of bovine mastitis: a comprehensive review

Sharun

Dhama

Tiwari

et al. 2021

Veterinary Quarterly

201

103

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Mastitis (intramammary inflammation) caused by infectious pathogens is still considered a devastating condition of dairy animals affecting animal welfare as well as economically incurring huge losses to the dairy industry by means of decreased production performance and increased culling rates. Bovine mastitis is the inflammation of the mammary glands/udder of bovines, caused by bacterial pathogens, in most cases. Routine diagnosis is based on clinical and subclinical forms of the disease. This underlines the significance of early and rapid identification/detection of etiological agents at the farm level, for which several diagnostic techniques have been developed. Therapeutic regimens such as antibiotics, immunotherapy, bacteriocins, bacteriophages, antimicrobial peptides, probiotics, stem cell therapy, native secretory factors, nutritional, dry cow and lactation therapy, genetic selection, herbs, and nanoparticle technology-based therapy have been evaluated for their efficacy in the treatment of mastitis. Even though several strategies have been developed over the years for the purpose of managing both clinical and subclinical forms of mastitis, all of them lacked the efficacy to eliminate the associated etiological agent when used as a monotherapy. Further, research has to be directed towards the development of new therapeutic agents/techniques that can both replace conventional techniques and also solve the problem of emerging antibiotic resistance. The objective of the present review is to describe the etiological agents, pathogenesis, and diagnosis in brief along with an extensive discussion on the advances in the treatment and management of mastitis, which would help safeguard the health of dairy animals.

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Section: Native Secretory Factorsmentioning

confidence: 98%

Advances in therapeutic and managemental approaches of bovine mastitis: a comprehensive review

Sharun

Dhama

Tiwari

et al. 2021

Veterinary Quarterly

201

103

View full text Add to dashboard Cite

show abstract

“…In addition to 'alternative therapies', such as prebiotics, probiotics, essential oils, and homeopathy, which are currently much debated (Keller and Sundrum 2018), there are 'alternative strategies' of recognised effectiveness (hygiene, biosecurity, health management schemes, vaccines) that are recommended to the farmer as an alternative to AMU.…”

Section: Alternative Strategies To Antimicrobialsmentioning

confidence: 99%

Antimicrobial use and antimicrobial resistance: standpoint and prescribing behaviour of Italian cattle and pig veterinarians

Pozza

Pinto

Crovato

et al. 2020

Italian Journal of Animal Science

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The scientific community considers the improper use of antimicrobials in farm animals among the causes of the insurgent bacterial resistance contributing to the wider pool of resistance at the animal/human interface with serious public health implications. The present study aims to describe the current perceptions regarding antimicrobial use (AMU) and resistance (AMR) and the prescribing behaviour of two different target groups: cattle and pig veterinary practitioners working in Italy. A semi-structured questionnaire was designed and administered using the Computer-Assisted Web Interviewing method. Among the 789 participants who completed the questionnaire, 53.5% and 12.2% were cattle and pig veterinarians, respectively. Differences between the two groups emerged in their opinions concerning different topics. For example, 69.4% and 85.8% of cattle veterinarians claimed to 'somewhat or strongly agree' with the statements 'prescribing broad-spectrum antibiotics in rearing farms increases AMR' and 'the preventive use of antibiotics fosters the development of AMR', against the observed 59.4% and 69.8% of pig veterinarians (p ¼ .050 and p ¼ .000, respectively). Moreover, 26% of pig veterinarians claimed to 'somewhat or strongly agree' with the statement 'alternative methods currently available could be an efficient alternative to antimicrobial treatment', against 16.1% of cattle veterinarians (p ¼ .022). At the same time, no differences between the two groups emerged regarding the danger inadequate AMU in animals poses on both animal and human health. From collected data, the need to provide appropriate training strategies with the aim of adopting a behaviour more consistent with the guidelines for prudent AMU in cattle and pig production systems has emerged. HIGHLIGHTS 85.8% of cattle vs. 69.8% of pig veterinarians agreed with the statement 'the preventive use of antibiotics fosters the development of AMR'. 64.5% of cattle and 69.1% of pig veterinarians declared they suggest/prescribe alternative approaches to the use of antimicrobials. 'Hygiene-biosecurity-management' and 'nutritive principles' are the alternative strategies most suggested by cattle and pig veterinarians, respectively.

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“…Accumast was found to be the most accurate for detection of mastitic pathogens. Keller and Sundrum (2018) opined that the antimicrobial therapy or alternative remedies like homeopathy should be based on bacterial culture of suspected mastitic milk sample. Further, for highly specific and confirmatory diagnosis, pure cultures still provide raw materials for more sophisticated diagnostic technological interventions like PCR and nucleotide sequencing.…”

Section: Diagnostics Through Technological Interventionsmentioning

confidence: 99%

Technological interventions and advances in the diagnosis of intramammary infections in animals with emphasis on bovine population—a review

Chakraborty¹,

Dhama

Tiwari

et al. 2019

Veterinary Quarterly

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Mastitis, an inflammation of the udder, is a challenging problem in dairy animals accounting for high economic losses. Disease complexity, degree of economic losses and increasing importance of the dairy industries along with public health concerns envisages devising appropriate diagnostics of mastitis, which can offer rapid, accurate and confirmatory diagnosis. The various diagnostic tests of mastitis have been divided into general or phenotypic and specific or genotypic tests. General or phenotypic tests are those that identify general alterations, which are not specific to any pathogen. Genotypic tests are specific, hence confirmatory for diagnosis of mastitis and include specific culture, polymerase chain reaction (PCR) and its various versions (e.g. qRT-PCR), loop-mediated isothermal amplification, lateral flow assays, nucleotide sequencing, matrix-assisted laser desorption ionization time-of-flight mass spectrometry, and other molecular diagnostic methods. However, for highly specific and confirmatory diagnosis, pure cultures still provide raw materials for more sophisticated diagnostic technological interventions like PCR and nucleotide sequencing. Diagnostic ability of like infra-red thermography (IRT) has been shown to be similar to California mastitis test and also differentiates clinical mastitis from subclinical mastitis cases. As such, IRT can become a convenient and portable diagnostic tool. Of note, magnetic nanoparticles-based colorimetric biosensor assay was developed by using for instance proteolytic activity of plasmin or anti-S. aureus antibody. Last but not least, microRNAs have been suggested to be potential biomarkers for diagnosing bovine mastitis. This review summarizes the various diagnostic tests available for detection of mastitis including diagnosis through general and specific technological interventions and advances.

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Comparative effectiveness of individualised homeopathy and antibiotics in the treatment of bovine clinical mastitis: randomised controlled trial

Cited by 19 publications

References 31 publications

Advances in therapeutic and managemental approaches of bovine mastitis: a comprehensive review

Advances in therapeutic and managemental approaches of bovine mastitis: a comprehensive review

Antimicrobial use and antimicrobial resistance: standpoint and prescribing behaviour of Italian cattle and pig veterinarians

Technological interventions and advances in the diagnosis of intramammary infections in animals with emphasis on bovine population—a review

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