Comparative effectiveness of iron-containing drugs for the prevention of iron deficiency anemia in piglets

Derkach, I. M.

doi:10.32718/nvlvet10210

Cited by 3 publications

(10 citation statements)

References 8 publications

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“…During the entire study period, the hematocrit was probably higher in the piglets of the control group, and the highest difference was on days 9 and 12 by 1.85 and 2.19 times, respectively. Such data coincide with previous studies (Derkach, 2021), according to which the hematocrit was probably higher in the control group during the whole period of the study, and the difference was also the highest on days 9 and 12 by 1.7 and 1.9 times, respectively. The findings of the current study indicated that the value of hematocrit in the blood of piglets of the experimental group was within physiological values.…”

Section: Resultssupporting

confidence: 92%

“…This tendency of changes in the hemoglobin content of piglets' blood in the experimental group under the influence of iron (IV) clathrochelate and cyanocobalamin differs slightly from the dynamics under the influence of iron (IV) clathrochelate. In previous studies (Derkach, 2021), it was noted that the hemoglobin content in the blood of piglets in the experimental group from days 5 to 30 was probably lower than the control by 1.1-1.3 times, while in other periods it did not differ from the control. However, under different prevention schemes in all periods of the study, the content of hemoglobin in the blood of piglets in the control and experimental groups was within physiological values.…”

Section: Resultsmentioning

confidence: 70%

“…At the time piglets aged 1, 12, 30, and 60 days, there was no difference between the piglets of the experimental and control groups regarding the number of erythrocytes and it was within physiological values. However, in the critical period of iron deficiency (on days 5-9 of life) this indicator was probably lower in the blood of piglets of the experimental group by 1.2 times, compared to the control group (Derkach, 2021).…”

Section: Resultsmentioning

confidence: 72%

“…However, it respectively increased by 1.25 and 1.87 times on days 9 and 12 (p < 0.05), compared with the control group. According to a previous study, the number of platelets in the blood of piglets of the experimental group differed from that in the blood of animals of the control group only on day 12 and was higher by 1.7 times (Derkach, 2021).…”

Section: Resultsmentioning

confidence: 82%

“…On day 12, this indicator was lower by 1.15 times. In the current study addressing the effect of only iron (IV) clathrochelate (Derkach, 2021), the changes in the number of leukocytes were characterized by the fact that on days 5 and 12 of life in the blood of piglets in the experimental group, their rate was higher by 1.2 times than the control.…”

Section: Resultsmentioning

confidence: 98%

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Dynamics of Morphological Indicators of Blood of Piglets under the Influence of Iron Clathrochelate Complex and Cyanocobalamin

Дeркач¹,

Derkach²,

Деркач³

et al. 2021

WVJ

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Iron deficiency anemia is one of the most common non-contagious diseases of piglets. Veterinary antianemic drugs have several drawbacks, so finding new medicines is an important current task for scientists. Therefore, the present study investigated the antianemic effect of iron (IV) clathrochelate in the organism of piglets. The subsequent studies included the exploration of its antianemic actions, particularly in combination with cyanocobalamin when this combination was administered to sows for prophylaxis in piglets. The experiment was carried out on 30 suckling piglets during the period of their detention with sows. According to the method of analogue groups, two groups of control (I) and experimental (II, each containing 15 animals) were formed and they were studied for 30 days. The piglets from five sows (three from each) were selected for the experimental group. During the pregnancy of these sows, 10 ml of 10% solution of iron (IV) IV clathrochelate and solution of cyanocobalamin were injected intramuscularly twice 7 and 14 days before their expected farrowing. For prevention of iron deficiency anemia, the traditional solution of iron dextran was administered once intramuscularly to piglets of the control group. The investigative material included the blood samples of piglets considering the dynamics of probable changes in the number of erythrocytes, hemoglobin content and hematocrit, and other morphological indicators and blood indices of piglets. The dynamics of changes in erythrocyte count, hemoglobin content, hematocrit, leukocytes and platelets, indices of blood almost did not differ from the dynamics of these values when using only 10% solution of iron (IV) clathrochelate for pregnant sows. The proposed scheme for the prophylaxis of iron deficiency anemia in piglets, involving simultaneous intramuscular injections of IV clathrochelate and cyanocobalamin to pregnant sows, is somewhat inferior to the previous preventive measures, which included only the intramuscular injections of iron (IV) IV clathrochelate, but it can be recommended as highly effective.

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Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 70%

Section: Resultsmentioning

confidence: 72%

Section: Resultsmentioning

confidence: 82%

Section: Resultsmentioning

confidence: 98%

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Dynamics of Morphological Indicators of Blood of Piglets under the Influence of Iron Clathrochelate Complex and Cyanocobalamin

Дeркач¹,

Derkach²,

Деркач³

et al. 2021

WVJ

Self Cite

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Advantages and difficulties of ultrasound analysis to determine the fertile period in bitches

Holubiev,

Skliarov,

Pérez-Marín

et al. 2023

TAVM

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Definition the fertile period is one of the most important factors contributing to fertilization. Therefore, this analysis is important to solve the problem of infertility. The methods that available today do not provide the expected result, because the vast majority of unsuccessful mating result are related to the incorrect determination of the ovulation period. Therefore, it is important to assess the condition of the ovaries, and the prospect is ultrasound examination, which is an effective method of monitoring the reproductive organs. Ultrasound analysis is a non-invasive and effective method to establish the fertile period in bitches which makes it possible to track changes in the ovaries, detect follicles, their number, and determine the true (morphological) signs of ovulation. Clinicalvisual and hormonal studies which are based on the indirect determination of the optimal period of female insemination have the advantages in compare with vaginal cytology. Particularly, the use of ultrasound in real time allows to visualize the morphological changes of the ovaries and uterus -the irregular shape of the ovaries with large (0.6-1.2 cm) anechoic structures of a rounded or oval shape with a thin capsule, thickening of the endometrium (up to 0.5-0.8 cm) with a hypoechoic structure of the uterine horns. However, in our research we encountered certain difficulties, which turned out to be the same as other authors. Echography of the ovaries can seem a bit complicated, because the follicles that persist in them have a picture similar to that before and after ovulation. Some ovulated follicles do not always completely collapse (fall) during ovulation and are gradually replaced by luteal tissue while maintaining an echogenic picture on the days of the next ovulation. Non-ovulated follicles can complicate sonography interpretation. To diagnose ovulation, an ultrasound analysis should be performed twice a day, which is inconvenient for the owners. But if the ultrasound test is carried out less often than aforementioned number, there is a risk to miss the moment of ovulation, because the follicles before and after ovulation are very similar. An even more significant problem is the location of the ovaries in bitches -costovertebral angle surrounded by fat and an ovarian sac, which can create technical difficulties. In addition, this diagnostic approach may be more difficult in fat or very large dogs, as well as in dogs with thick skin (Shar Pei, Newfoundland).

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Supply of iron in piglets with colostrum/milk of sows using iron (IV) clatrochelate

Derkach

Деркач

Dukhnytskyi

et al. 2021

Nauk. vìsn. vet. med.

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Many works of both Ukrainian scientists and foreign are devoted to the study of the prevention of iron deficiency anemia in piglets as one of the most common non-communicable diseases of pigs. However, the development of new effective antianemic drugs is still relevant today. We have previously proposed a scheme for the prevention of iron deficiency anemia, based on intramuscular parallel administration of solutions of iron (IV) clatrochelate and cyanocobalaminе to pregnant sows 14 and 7 days before the expected farrowing. This scheme was effective in the absence of stillbirth and clinical signs of anemia in piglets. The aim of our next study was to investigate the content of iron in the milk of sows using iron (IV) clatrochelate during pregnancy. To achieve this goal, 2 groups of sows (hybrids of Landrace and Great White breeds) were formed during their pregnancy and kept with suckling piglets - control and experimental, 5 animals in each. Sows in the experimental group were injected twice (14 and 7 days before expected farrowing) with 10 ml of 10% iron (IV) clatrochelate solution and cyanocobalaminе solution (at the dose recommended by official instructions) twice during pregnancy. Sows of the control group were injected with isotonic sodium chloride solution in conventional doses. During the experiment, the sows of the experimental group during pregnancy (after drug administration) and during the feeding of piglets did not differ in behavior and general condition from the sows of the control group. The study of the dynamics of hemoglobin and morphological parameters of the blood of sows in the control and experimental groups did not reveal significant differences. The content of iron in colostrum / milk of sows of the experimental group during the first seven days after administration was significantly higher compared to the control: 1 day 1.5 times, 4 days 2.1 times and 7 days 2.8 times. Therefore, the proposed scheme for the prevention of iron deficiency anemia in piglets is highly efficientand based on the intake of iron with colostrum/milk of sows. Key words: anemia, injection, macrobicyclic complex, prophylaxis, pigs, cyanocobalaminе.

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Comparative effectiveness of iron-containing drugs for the prevention of iron deficiency anemia in piglets

Cited by 3 publications

References 8 publications

Dynamics of Morphological Indicators of Blood of Piglets under the Influence of Iron Clathrochelate Complex and Cyanocobalamin

Dynamics of Morphological Indicators of Blood of Piglets under the Influence of Iron Clathrochelate Complex and Cyanocobalamin

Advantages and difficulties of ultrasound analysis to determine the fertile period in bitches

Supply of iron in piglets with colostrum/milk of sows using iron (IV) clatrochelate

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