Comparative effectiveness of Tamsulosin and Tadalafil therapy in ureteral stents-related symptoms (uSRS)

Ilyas, Muh. Reski Fadly; Kholis, Khoirul; Palinrungi, Muhammad Asykar; Palinrungi, Achmad M.; Seweng, Arifin; Syahrir, Syakri; Syarif,

doi:10.1016/j.mcpsp.2021.100226

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…In 2021 Ilyas MRF et al informed that Tadalafil 10 mg demonstrate significantly better results compared to Tamsulosin 0.4 mg in improving USRs [ 5 ]. It is common knowledge that PDE-5 receptors are present in the lower part of ureter, bladder trigone and neck.…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of combination therapy Tadalafil plus Tamsulosin in ureteral stents-related symptoms relief

2023

Cent European J Urol

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Introduction Ureteral stents-related symptoms (USRs) are the common complications of ureteral stenting. Tamsulosin a selective alpha-1 blocker and Tadalafil a PDE-5 inhibitor are one of drugs have been used for USRs relief. In this study we aimed to evaluate the effectiveness and safety of combination therapy Tamsulosin+Tadalafil for treating USRs comparing it with the efficacy of either Tamsulosin or Tadalafil monotherapies. Material and methods 279 patients with indwelled unilateral ureteral stents were randomized to Tamsulosin 0.4 mg + Tadalafil 5 mg once a day (Group 1, n = 67), Tamsulosin 0.4 mg once a day (Group 2, n = 71), Tadalafil 5 mg once a day (Group 3, n = 69) and Placebo once a day (Group 4, n = 72). USRs severity was registered and calculated by using the Ureteral Symptoms Score Questionnaire (USSQ) at the 14 th day of treatment. Side-effects and total analgesic use were recorded and compared. Results At the endpoint in patients with unilateral ureteral stents the combination therapy Tamsulosin + Tadalafil led to statistically lower intensity of urinary symptoms comparing with Tamsulosin (15.2 ±4.3 vs 21.8±3.6, p = 0.0003) or Tadalafil (15.2 ±4.3 vs 20.6 ±2.8, p = 0.0004) monotherapy. All groups of treatment demonstrated significant relief of USRs comparing with Placebo mostly beneficial in the combined therapy group. Body pain and analgesic need in Group 1 was lower than in Groups 2, 3 or 4. Side-effects were registered rarely without statistical differences in frequency between groups. Conclusions Combination therapy with Tamsulosin + Tadalafil is an effective and safe option that achieves the statistically more significant relief of USRs comparing with Tadalafil or Tamsulosin monotherapies.

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Section: Discussionmentioning

confidence: 99%

“…Last years, numerous publications informed about the impact of phosphodiesterase-5 (PDE-5) inhibitor Tadalafil, initially designed as erectile dysfunction correction drug, on USRs intensity. The effisacy of Tamsulosin and Tadalafil for elimination of USRs is comparing [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of combination therapy Tadalafil plus Tamsulosin in ureteral stents-related symptoms relief

2023

Cent European J Urol

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Double-J stent-related lower urinary tract symptoms: a prospective randomized trial of mirabegron, solifenacin, tamsulosin, and tadalafil and their combinations

PALINRUNGI,

RASYID,

PRIHANTONO

et al. 2023

Gazz Med Ital - Arch Sci Med

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Comparative effectiveness of Tamsulosin and Tadalafil therapy in ureteral stents-related symptoms (uSRS)

Cited by 2 publications

References 14 publications

Efficacy of combination therapy Tadalafil plus Tamsulosin in ureteral stents-related symptoms relief

Efficacy of combination therapy Tadalafil plus Tamsulosin in ureteral stents-related symptoms relief

Double-J stent-related lower urinary tract symptoms: a prospective randomized trial of mirabegron, solifenacin, tamsulosin, and tadalafil and their combinations

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