Comparative effectiveness of the tumour diagnostics, CA 19-9, CA 125 and carcinoembryonic antigen in patients with diseases of the digestive system.

Saito, Kiyoshi; Haga, Yoshio; Yoshimura, R; Egami, Hiroshi; Yokoyama, Y; Akagi, Masanobu

doi:10.1136/gut.28.3.323

Cited by 84 publications

(53 citation statements)

References 20 publications

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“…Our data are confirmed by similar reports of other investigators [4,21,22], Furthermore, our data present evidence that polyamines might play a clinical role in the postoperative monitoring as predictors of therapeutical success or indicators of tu mor relapse, since urinary polyamines proved to be normalized in our patients after successful curative therapy, while they were further elevated in patients with relapse of the tumor or proven metastases confirming previous reports [5,[21][22][23], Due to the higher sensitivity of several polyamines for gastrointestinal cancer (i.e. total spermidine or total putrescine) compared to CEA, CA 19-9 or CA 125 [24,25], polyamine analysis in serum or urine might be superior in the postoperative monitoring of cancer patients particularly in those where CEA or CA 19-9 were normal preoperatively. On the other hand the combined screening of all markers in the postoperative state might increase the probability even more to detect relapses.…”

Section: Discussionsupporting

confidence: 74%

Polyamines in Human Gastrointestinal Malignancies

Löser

Fölsch²,

Paprotny³

et al. 1990

Digestion

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This study was designed to investigate the clinical relevance of polyamine determination in human tissue, serum, and urine as diagnostic markers in the diagnosis or postoperative control of patients with gastrointestinal cancer. Total, free, and acetylated polyamines were measured simultaneously in tissue, serum, and urine of patients with esophageal (n = 16), gastric (n = 40), pancreatic (n = 20) or colorectal (n = 50) carcinoma, in 40 patients with non-malignant gastrointestinal diseases, and 30 healthy volunteers. Though sensitivity of polyamines for gastrointestinal cancer proved to be high, non-malignant gastrointestinal diseases partly showed similar elevated polyamine concentrations in urine and serum which resulted in a low specificity of polyamines for gastrointestinal cancer. Therefore polyamines are not suitable as diagnostic markers in tumor screening. Furthermore, since polyamine concentrations in serum and urine normalized after curative operation while they were further increased and elevated in patients with proven relapse of the tumor or metastases, polyamines might be of clinical value in postoperative monitoring of therapeutical success or predicting relapse of the tumor.

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Section: Discussionsupporting

confidence: 74%

Polyamines in Human Gastrointestinal Malignancies

Löser

Fölsch²,

Paprotny³

et al. 1990

Digestion

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“…Its levels correlate well with pancreatic cancer staging.80% of patients with pancreatic carcinoma, 67% of hepatobiliary, 40-50% of gastric carcinoma patients show high CA 19.9 (>37U/L). Raised levels of this marker in gastric carcinoma has also been reported by various investigators (3,5,6). Yamao et al (7) have shown elevation of CA 19.9 levels in 26 patients of gastric carcinoma with mean value of 163 U/ mL range being (53.8-873.5).…”

supporting

confidence: 66%

“…Increase in serum CA19.9 was reported as more than 10,000 U / mL in patients of pancreatic carcinoma. High values were found in localized as well as disseminated diseases (5). In yet another study evaluating the rise in tumor markers in gastric carcinoma patients, Sumiya et al have reported serum CEA levels between 5 -496 ng/mL and CA 19.9 levels of 37-9887 U/mL in 549 patients of gastric carcinoma (12).…”

mentioning

confidence: 99%

Unusually high serum CA19.9 in gastric carcinoma: A case report

Thakur

Mukherjee

2008

Indian J Clin Biochem

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We describe a case of poorly differentiated adenocarcinoma of stomach, which did not present typical symptoms of gastrointestinal malignancy on first visit. The patient, a 62 year old smoker presented with shortness of breathe and pain in right lumbar region with no history of fever. Bone scans revealed multiple hot spots in skull, sternum, lumbar vertebrae and both iliac crests. A series of tumor markers were ordered which include PSA, CEA, CA19.9, CA 72.4 and AFP. Serum PSA and AFP concentrations were within normal range. Serum CEA and CA 72.4 were raised significantly. Markedly elevated levels of serum CA19.9 were found (>45000 U/ ml) in this patient. CT chest and bronchoscopic examination ruled out the possibility of cancer lung. Upper GI tract endoscopy was done to find out lesion in GI tract. An ulcerative lesion was found in lesser curvature of stomach. Histopathological examination of endoscopic biopsy revealed a poorly differentiated adenocarcinoma of stomach. An unusually high serum CA19.9 (>45000U/ml) in case of gastric carcinoma has not been reported earlier.

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“…(Metzgar et al, 1984;Sawabu et al, 1986;Mahvi et al, 1988); it appears to be lower than that found by us and others for CA 19-9 (Farini et al, 1985;Malesci et al, 1987;Steinberg et al, 1986;Sakamoto et al, 1987;Pleskow et al, 1989 (Suzuki et al, 1988;Haviland et al, 1988), suggests that this antigen behaves similarly to CA 19-9.…”

Section: Methodsmentioning

confidence: 51%