Comparative effects of a Mg-enriched diet and different orally administered magnesium oxide preparations on ionized Mg, Mg metabolism and electrolytes in serum of human volunteers.

Altura, Bella T.; Wilimzig, C.; Trnovec, T.; Nyulassy, S

doi:10.1080/07315724.1994.10718433

Cited by 41 publications

(32 citation statements)

References 12 publications

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“…However, Johansson and Whiss [55] reported that the correlation of ionized Mg (iMg2 + ) and total Mg in serum is weak. Altura et al [56] also found that short-term dietary elevations in Mg intake can result in a significant elevation of serum ionized Mg, although total serum Mg is unaffected. Therefore, the beneficial effects of dietary Mg might be mediated by higher concentrations of ionized Mg, which is not measured at the present study.…”

Section: Discussionmentioning

confidence: 96%

Zinc in a Combination with Magnesium Helps Reducing Negative Effects of Heat Stress in Quails

Küçük

2008

Biol Trace Elem Res

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The objective of this study was to investigate whether zinc (Zn) along with magnesium (Mg) is effective in alleviating the negative effects of heat stress in Japanese quails. One hundred and twenty 10-day-old healthy Japanese quails were randomly assigned to four treatment groups, three replicates of ten birds each. The birds were fed either a basal diet or the basal diet supplemented with either 30 mg of Zn/kg of diet, 600 mg of Mg/kg of diet, or 30 mg of Zn + 600 mg of Mg/kg of diet. The birds were kept under a high temperature (35 degrees C) for 8 h/day. Feed consumption was greatest with the combination of Zn and Mg supplementation (P < 0.01). Hot and chilled dressing percentages were greater (P < 0.05) with Zn- and Mg-supplemented diets. Concentrations of plasma malondialdehyde were lower (P < 0.01) with both Zn and Mg supplementations. Mg concentrations in the serum remained similar with either Zn or Mg supplements in the diet (P > 0.05). Serum glucose concentrations were lowest in birds fed the basal diet. Supplementing a combination of Zn and Mg may offer a potential protective management practice in preventing heat stress-related depression in performance of quails.

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Section: Discussionmentioning

confidence: 96%

Zinc in a Combination with Magnesium Helps Reducing Negative Effects of Heat Stress in Quails

Küçük

2008

Biol Trace Elem Res

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“…Other studies suggest that populations consuming low levels of Mg are at greater risk for cardiovascular disease than populations consuming diets enriched in Mg [4][5][6][7]. While it is difficult to assess the incidence of Mg deficiency (MgD) in the general population due to the lack of universally accepted testing methods, standard clinical laboratory techniques have shown that hypomagnesemia is a common condition in hospitalized patients: 63% of intensive care patients exhibited hypomagnesemia [8], and 45% of patients with acute myocardial infarction had hypomagnesemia [9]. Mgwasting also occurs in other segments of the population (e.g.…”

Section: Introductionmentioning

confidence: 99%

The nerve-heart connection in the pro-oxidant response to Mg-deficiency

et al. 2006

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Magnesium is a micronutrient essential for the normal functioning of the cardiovascular system, and Mg deficiency (MgD) is frequently associated in the clinical setting with chronic pathologies such as CHF, diabetes, hypertension, and other pathologies. Animal models of MgD have demonstrated a systemic pro-inflammatory/pro-oxidant state, involving multiple tissues/organs including neuronal, hematopoietic, cardiovascular, and gastrointestinal systems; during later stages of MgD, a cardiomyopathy develops which may result from a cascade of inflammatory events. In rodent models of dietary MgD, a significant rise in circulating levels of proinflammatory neuropeptides such as substance P (SP) and calcitonin gene-related peptide among others, was observed within days (1-7) of initiating the Mg-restricted diet, and implicated a neurogenic trigger for the subsequent inflammatory events; this early "neurogenic inflammation" phase may be mediated in part, by the Mg-gated N: -methyl-D-aspartate (NMDA) receptor/channel complex. Deregulation of the NMDA receptor may trigger the abrupt release of neuronal SP from the sensory-motor C-fibers to promote the subsequent pro-inflammatory changes: elevations in circulating inflammatory cells, inflammatory cytokines, histamine, and PGE(2) levels, as well as formation of nitric oxide, reactive oxygen species, lipid peroxidation products, and depletion of key endogenous antioxidants. Concurrent elevations of tissue CD14, a high affinity receptor for lipopolyssacharide, suggest that intestinal permeability may be compromised leading to endotoxemia. If exposure to these early (1-3 weeks MgD) inflammatory/pro-oxidant events becomes prolonged, this might lead to impaired cardiac function, and when co-existing with other pathologies, may enhance the risk of developing chronic heart failure.

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“…Epidemiological studies suggest that populations consuming low levels of Mg 2ϩ are at greater risk of morbidity after a myocardial ischemic response episode than populations consuming enriched Mg 2ϩ (Leary, 1986;Rylander et al, 1991). Hypomagnesemia is also common in hospitalized patients: 63% of intensive care patients exhibited hypomagnesemia (Altura et al, 1994), and 45% of patients with acute myocardial infarction had low Mg 2ϩ levels (Vormann et al, 1983). Mg 2ϩ wasting also occurs in other segments of the population, such as diabetics, alcoholics, human immunodeficiency virus-infected patients, leading to overt hypomagnesemia (Altura and Altura, 1985;Dubey and Solomon, 1989;Seelig, 1989).…”

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confidence: 99%

N-Methyl-d-aspartate Receptor Blockade Inhibits Cardiac Inflammation in the Mg²+-Deficient Rat

Tejero-Taldo

Chmielinska²,

Gonzalez³

et al. 2004

J Pharmacol Exp Ther

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Elevated plasma levels of the neuropeptide substance P (SP) precede the perivascular inflammatory infiltrate seen in hearts of Mg 2ϩ -deficient (MgD) animals. The N-methyl-D-aspartate (NMDA) receptor is found in neurons, and activation of this receptor participates in SP release; under normal circumstances, this release can be blocked by Mg 2ϩ . Therefore, we reasoned that blockade of the NMDA receptor with dizolcipine maleate (a noncompetitive NMDA receptor antagonist) would prevent SP release from C-fibers due to MgD. In this study, animals were implanted with slow-release pellets containing dizolcipine or placebo and were fed with diet sufficient in Mg 2ϩ or deficient with only 9% of USDA-recommended Mg 2ϩ . SP immunostaining of dorsal root ganglia showed a time-dependent depletion of SP in the MgD animals, with a dramatic decrease of SP by week 2; this depletion was prevented by pretreatment with dizolcipine maleate. The significant increase in plasma prostaglandin E 2 levels during MgD was prevented by dizolcipine, and the loss of total red blood cell glutathione content was significantly attenuated by NMDA blockade after 3 weeks of MgD (p Ͻ 0.01 versus controls). Immunohistochemical and Western blot analyses of ventricular tissue demonstrated that NMDA receptor blockade abolished MgD-related increase of endothelium adhesion molecule CD54 (weeks 1 and 2; p Ͻ 0.05), and of monocyte/macrophage surface protein CD11b expression (week 3; p Ͻ 0.05). We conclude that NMDA receptor blockade with dizolcipine maleate prevented SP depletion and reduced perivascular inflammatory infiltrates, thus decreasing cardiac injury due to Mg 2ϩ deficiency.

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Comparative effects of a Mg-enriched diet and different orally administered magnesium oxide preparations on ionized Mg, Mg metabolism and electrolytes in serum of human volunteers.

Abstract: These results indicate that since serum IMg2+ and % IMg2+, but not TMg, can be altered by dietary intake, previous or future findings which may indicate no change in TMg by diet may not reflect changes in biologically-active Mg.

Cited by 41 publications

References 12 publications

Zinc in a Combination with Magnesium Helps Reducing Negative Effects of Heat Stress in Quails

Zinc in a Combination with Magnesium Helps Reducing Negative Effects of Heat Stress in Quails

The nerve-heart connection in the pro-oxidant response to Mg-deficiency

N-Methyl-d-aspartate Receptor Blockade Inhibits Cardiac Inflammation in the Mg²+-Deficient Rat

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Comparative effects of a Mg-enriched diet and different orally administered magnesium oxide preparations on ionized Mg, Mg metabolism and electrolytes in serum of human volunteers.

Abstract: These results indicate that since serum IMg2+ and % IMg2+, but not TMg, can be altered by dietary intake, previous or future findings which may indicate no change in TMg by diet may not reflect changes in biologically-active Mg.

Cited by 41 publications

References 12 publications

Zinc in a Combination with Magnesium Helps Reducing Negative Effects of Heat Stress in Quails

Zinc in a Combination with Magnesium Helps Reducing Negative Effects of Heat Stress in Quails

The nerve-heart connection in the pro-oxidant response to Mg-deficiency

N-Methyl-d-aspartate Receptor Blockade Inhibits Cardiac Inflammation in the Mg2+-Deficient Rat

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Product

Resources

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N-Methyl-d-aspartate Receptor Blockade Inhibits Cardiac Inflammation in the Mg²+-Deficient Rat