Comparative effects of abamectin and two formulations of ivermectin on the survival of larvae of a dung‐breeding fly

Kg, Wardhaugh; Rj, Mahon

doi:10.1111/j.1751-0813.1998.tb10158.x

Cited by 20 publications

(15 citation statements)

References 15 publications

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“…Similar assays with M. vetustissima [174], M. autumnalis [175-176], and M. domestica [174] detected lethal effects for 28 to 35, 14 to 28, and 7 to 14 days, respectively. Treatment of cattle with an injectable formulation of 200 µg IVM kg -1 body weight inhibited larval growth and prevented emergence of adults of Musca domestica (house fly) [174, 177-178] and M. vetustissima (bush fly) [155-156] for 7-14 days post-treatment. An oral drench of 200 µg IVM kg -1 live weight to sheep prevented emergence of M. vetustissima for the first 4-6 days post-treatment of animals, with 100% survival at day 28 [100], and delayed reproductive development of Lucila cuprina (sheep blowfly) [169-170].…”

Section: Ecotoxicity Of Avermectinsmentioning

confidence: 99%

“…Due to strong binding of IVM to soil [214] and, thus, little potential for transport from the terrestrial to the aquatic compartment, no risk for aquatic organisms was indicated in previous environmental risk assessments of IVM [74, 120, 156]. As a result, very few studies have been undertaken to examine the adverse impacts of exposure to IVM on freshwater organisms.…”

Section: Ecotoxicity Of Avermectinsmentioning

confidence: 99%

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A Review on the Toxicity and Non-Target Effects of Macrocyclic Lactones in Terrestrial and Aquatic Environments

Lumaret

Errouissi²,

Floate³

et al. 2012

CPB

298

215

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The avermectins, milbemycins and spinosyns are collectively referred to as macrocyclic lactones (MLs) which comprise several classes of chemicals derived from cultures of soil micro-organisms. These compounds are extensively and increasingly used in veterinary medicine and agriculture. Due to their potential effects on non-target organisms, large amounts of information on their impact in the environment has been compiled in recent years, mainly caused by legal requirements related to their marketing authorization or registration. The main objective of this paper is to critically review the present knowledge about the acute and chronic ecotoxicological effects of MLs on organisms, mainly invertebrates, in the terrestrial and aquatic environment. Detailed information is presented on the mode-of-action as well as the ecotoxicity of the most important compounds representing the three groups of MLs. This information, based on more than 360 references, is mainly provided in nine tables, presenting the effects of abamectin, ivermectin, eprinomectin, doramectin, emamectin, moxidectin, and spinosad on individual species of terrestrial and aquatic invertebrates as well as plants and algae. Since dung dwelling organisms are particularly important non-targets, as they are exposed via dung from treated animals over their whole life-cycle, the information on the effects of MLs on dung communities is compiled in an additional table. The results of this review clearly demonstrate that regarding environmental impacts many macrocyclic lactones are substances of high concern particularly with larval instars of invertebrates. Recent studies have also shown that susceptibility varies with life cycle stage and impacts can be mitigated by using MLs when these stages are not present. However information on the environmental impact of the MLs is scattered across a wide range of specialised scientific journals with research focusing mainly on ivermectin and to a lesser extent on abamectin doramectin and moxidectin. By comparison, information on compounds such as eprinomectin, emamectin and selamectin is still relatively scarce.

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Section: Ecotoxicity Of Avermectinsmentioning

confidence: 99%

Section: Ecotoxicity Of Avermectinsmentioning

confidence: 99%

A Review on the Toxicity and Non-Target Effects of Macrocyclic Lactones in Terrestrial and Aquatic Environments

Lumaret

Errouissi²,

Floate³

et al. 2012

CPB

298

215

View full text Add to dashboard Cite

show abstract

“…, 1993; Strong & James, 1993; Strong et al. , 1996; Wardhaugh & Mahon, 1998; Floate, 1999; Errouissi et al. , 2001; Wardhaugh et al.…”

Section: Environmental Effectsmentioning

confidence: 99%

Veterinary pharmacovigilance. Part 3. Adverse effects of veterinary medicinal products in animals and on the environment

Woodward¹

2005

Vet Pharm & Therapeutics

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Like humans, animals may experience adverse effects when treated with medicinal products. These effects may be related to the pharmacological or toxicological properties of the substances used or they may arise because of hypersensitivity. Veterinary medicinal products may also possess the ability to harm the environment. This paper reviews the potential of veterinary medicinal products to cause adverse effects in animals and on the environment.

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“…Wardhaugh and Mahon [33] in Australia observed that injectable formulation of abamectin and ivermectin appear to be equally toxic for larvae of Musca vetustissima, while the oral formulation of ivermectin seems to be less harmful. Strong et al [25], working with cattle dung following the administration of ivermectin sustained-release boluses, conclude that residues prevent fauna colonisation 3-weeks after administration.…”

Section: Differences Between Endectocides For Residue Toxicitymentioning

confidence: 99%

“…Non-target and target Diptera larvae, which in some seasons are very important to dung aeration, react negatively but not in the same way to endectocides. Nematocerous Diptera are able to tolerate dung, 10 days after treatment, while Cyclorrapha [16] or Musca vetustissima, Musca domestica, and Haematobia irritans [33], remain at risk for a period of 30-35 days. These avermectin effects range from acute or chronic mortality by paralysis and feeding or growth and moulting interference [23], or sublethal and long-term consequences like reproductive deficiencies [14] or external structural abnormalities [6].…”

Section: Effects On Dung Arthropodsmentioning

confidence: 99%

Helminthic control on grazing ruminants and environmental risks in South America

Suárez¹

2002

Vet. Res.

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-The control of ruminant gastrointestinal nematodes and ectoparasites, one of the major production health problems, are heavily reliant on the systematic and sometimes abusive use of anthelmintic drugs. Endectocides are the most frequently used drugs, having high potency against arthropods and nematodes. Their dung pat residues enhance the risk of adverse effects on non-target invertebrates and on the general grazing cattle ecosystem. In this scenario, our objective is to review current knowledge of the agro-environmental and biodiversity impact and risks of endectocides in South America. The effects of faecal drug residues of ivermectin and doramectin on dung colonising invertebrates and dung degradation have been reported in studies carried out in the temperate centre of Argentina and in the subtropical region of Brazil. The results from Argentina showed a depression in invertebrate colonisation and degradation of dung recovered from endectocide treated cattle during the autumn. Comparisons have shown that ivermectin and doramectin have similar adverse effects. A decrease of Coleoptera larvae, Diptera larvae, Staphylinidae, Collembola, Acari and dung specific nematodes was noted in pats from both endectocides. The results from Brazil showed that dipterous larvae, Polyphaga coleopteran larvae and adults and mites were significantly reduced in the ivermectin treated group. The disturbances that macrocyclic lactones can produce on non-targeted invertebrates and on their associated participation in dung degradation and soil element recycling, are unpredictable and can negatively influence biodiversity and the agricultural ecosystem sustainability.endectocide / environmental risk / South America / cattle grazing system / dung fauna Résumé -Contrôle des helminthes chez les ruminants à l'herbe et risques environnementaux en Amérique du Sud. Le contrôle des nématodes gastro-intestinaux et des ectoparasites, qui est l'un des problèmes de santé majeurs dans la production bovine, repose largement sur l'utilisation systé-matique et parfois abusive d'anthelmintiques. Les endectocides, qui ont un effet puissant contre les arthropodes et les nématodes, sont les médicaments le plus fréquemment utilisés. Leurs résidus dans les matières fécales augmentent les risques d'effets nocifs sur des invertébrés qui ne sont pas la cible 563

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Comparative effects of abamectin and two formulations of ivermectin on the survival of larvae of a dung‐breeding fly

Abstract: The oral formulation of ivermectin is eliminated more rapidly than the injectable formulation and, as a consequence, is likely to be less harmful to dung-feeding insects. Abamectin and ivermectin appear to equally toxic larvae of M vetustissima.

Cited by 20 publications

References 15 publications

A Review on the Toxicity and Non-Target Effects of Macrocyclic Lactones in Terrestrial and Aquatic Environments

A Review on the Toxicity and Non-Target Effects of Macrocyclic Lactones in Terrestrial and Aquatic Environments

Veterinary pharmacovigilance. Part 3. Adverse effects of veterinary medicinal products in animals and on the environment

Helminthic control on grazing ruminants and environmental risks in South America

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