Comparative effects of bisoprolol and acebutolol in smokers with airway obstruction.

Abstract

1. The effects of single oral doses of 10 mg bisoprolol and 400 mg acebutolol on respiratory function were studied in nine smokers with airway obstruction in a double‐blind, placebo‐controlled experiment. 2. The effects of the drugs were assessed by measuring specific airway conductance (sGaw) for 3 h after their administration and by studying their interaction with the bronchodilator response to inhaled salbutamol. 3. sGaw did not change for 3 h after bisoprolol or acebutolol administration. The bronchodilator response to inhaled salbutamol was not affected by bisoprolol but significantly reduced by acebutolol (P less than 0.05 vs placebo). 4. Under these conditions, bisoprolol behaves like a selective beta 1‐adrenoceptor antagonist but acebutolol exhibits less beta 1‐adrenoceptor selectivity.

Comparative beta‐adrenoceptor blocking effects of propranolol, bisoprolol, atenolol, acebutolol and diacetolol on the human isolated bronchus.

“…This high safety margin has also been emphasized by Macquin-Mavier et al (1988), who showed that, contrary to acebutolol 400 mg, bisoprolol in doses of 10 mg has no effect on the dose-response curves of salbutamol in smokers with chronic bronchitis in agreement with Lammers et al (1984), Dorow & Tonnesmann (1984) and Dorow et al (1986).…”

“…The persistent partial 3-adrenoceptor blocking effects of acebutolol, elicited by a decrease in bronchial response to salbutamol or terbutaline, has also been demonstrated in asthmatics or in smokers with chronic bronchitis who received 400 mg of acebutolol (Greefhorst & van Herwaarden, 1982;Macquin-Mavier et al, 1988). In addition, Whitsett et al (1982) References are: (1) Duchin etal.…”

“…There are, however, differences in the degree of selectivity of the cardioselective ,-adrenoceptor blockers since they displace to varying extents the bronchial dose-response curves to 32-adrenoceptor stimulants. In clinical studies, atenolol or bisoprolol appeared to be more selective than other compounds, such as acebutolol, metoprolol or oxprenolol (Greefhorst & van Herwaarden, 1982;Gribbin et al, 1981;Lammers et al, 1984;Lawrence et al, 1982;Macquin-Mavier et al, 1988;Perks et al, 1978;Ruffin et al, 1979;Tattersfield et al, 1984). Bronchial rings from a segmental bronchus were prepared and suspended in parallel in Krebs solution under an initial tension of 2.5 g. After 1.5 h of equilibration, the resting tension was between 1 and 2 g. Tensions were measured isometrically with strain gauges, amplifiers and .O.S..-Moise 2 recorder system (Celaster, Celle l'Evescault, 86600 Lusignan, France) (Advenier et al, 1986).…”

Heart Failure and Chronic Obstructive Pulmonary Disease

“…Medical subject heading (MeSH) terms "respiratory tract diseases" and "adrenergic beta-antagonists" yielded 227 studies, 18 of which addressed the review objectives (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22). Key word searches "chronic obstructive lung disease" and "beta adrenergic receptor blocking agent" or "[beta-blocker name]" identified 2 further studies (23,24).…”

“…A Cochrane library meta-analysis concluded that long-term cardioselective beta-blockade is safe and well-tolerated in COPD (25,62). This meta-analysis evaluated pulmonary function in 20 randomized, controlled, crossover trials of cardioselective beta 1 -blockers in patients with COPD (Table 2) (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24). No study included any patients with HF.…”