Introduction: Shoulder calcification, also known as calcific tendinopathy, is a common cause of shoulder pain, typically occurring between the ages of 30 and 50. It is approximately twice as common in women compared to men. The pathogenesis of the disease is not well understood, and it exhibits a cyclic nature. Objective: To investigate and assess the impact of ultrasound and manual therapy on reducing shoulder calcifications. Materials and Methods: This study, conducted at the Rehabilitation Center "Život" in Mostar from May to July 2023, involved 30 participants. Statistical analysis, using Microsoft Excel 2010 and IBM SPSS 23.0, included descriptive and inferential statistics, revealing significant insights into participants' perspectives and forming thebasis for a comprehensive discussion. Results: The research results demonstrated a statistically significant reduction in pain intensity after therapy, both in men and women. Additionally, calcification size significantly decreased, and shoulder range ofmotion improved. Analysis of demographic factors revealed differences between female and male participants, emphasizing the prompt seeking of therapy after the onset of pain.Conclusion: The combination of ultrasound and manual therapy shows promising effectiveness in treating shoulder calcifications, laying the groundwork for further study and personalized clinical practice.Keywords:calcification in the shoulder, manual therapy, ultrasound therapy.Correspondence: Darko Bilić, Master of Physiotherapy