Comparative effects of carbamazepine, phenytoin, diazepam and clonazepam on inhibitory avoidance learning in mice

Voigt, Jörg-Peter; Morgenstern, E.

doi:10.1007/bf02245297

Cited by 9 publications

(3 citation statements)

References 27 publications

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“…The drug doses were calculated from the salt form and based on doses used previously [4,[24][25][26]. Commercially available PHEN solution (Hidantal; Sanofi-Aventis, Suzano, SP, Brazil) was diluted in distilled water and administered intraperitoneally (i.p.)…”

Section: Drugsmentioning

confidence: 99%

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The antimanic‐like effect of phenytoin and carbamazepine on methylphenidate‐induced hyperlocomotion: role of voltage‐gated sodium channels

Tonelli

Pereira

Siba

et al. 2013

Fundamemntal Clinical Pharma

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The objective of this study was to verify whether phenytoin modifies methylphenidate-induced hyperlocomotion, an animal model for screening antimanic-like drugs, and also evaluate the effect of veratrine, a voltage-gated sodium channel opener, pretreatment on the effect of phenytoin in this model. Carbamazepine was used as a positive control. Methylphenidate (5 mg/kg, s.c.) increased open-field locomotion, and phenytoin (5-10 mg/kg, i.p.) and carbamazepine (20 mg/kg, i.p.) blocked this effect. Veratrine (0.4 mg/kg, s.c.) pretreatment reversed the effects of phenytoin (10 mg/kg, i.p.) and carbamazepine (20 mg/kg, i.p.). Phenytoin (1-50 mg/kg, i.p.) and carbamazepine (10-20 mg/kg i.p.) alone did not change spontaneous locomotor activity. These results indicate that voltage-gated sodium channels play an important role in antimanic-like effects of phenytoin and carbamazepine on psychostimulant-induced hyperlocomotion model.

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Section: Drugsmentioning

confidence: 99%

“…All of the drugs and their vehicles were administered in a constant volume of 10 ml/kg. The drug doses were calculated from the salt form and based on doses used previously [4,[24][25][26]. The dose of veratrine (dissolved in saline; Sigma-Aldrich) was based on a pilot study that showed that 0.4 mg/kg did not alter hyperlocomotion induced by MPH.…”

Section: Drugsmentioning

confidence: 99%

The antimanic‐like effect of phenytoin and carbamazepine on methylphenidate‐induced hyperlocomotion: role of voltage‐gated sodium channels

Tonelli

Pereira

Siba

et al. 2013

Fundamemntal Clinical Pharma

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“…Esses dados assemelham-se a estudos que investigaram os efeitos de benzodiazepínicos na esquiva inibitória em camundongos, em que foi relatado que a administração de benzodiazepínicos prejudicou a tarefa de esquiva inibitória com o animal, exibindo significativamente menos tempo para entrar no compartimento no qual sua resposta foi punida (Nabeshima, Tohyama, Ichihara, & Kameyama, 1990;Voigt & Morgenstern, 1992).…”

Section: Discussionunclassified

Efeitos Do Clonazepam Na Esquiva Inibitória No Peixe-Dourado (Carassius Auratus)

Carvalho

Gouvêia

2012

REBAC

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O objetivo do presente trabalho foi verificar o efeito do clonazepam na esquiva inibitória (EI) de um ambiente branco em peixes-dourados, descrito como aversivo para peixes dessa espécie. Foram utilizados 30 peixes dourados distribuídos em quatro grupos, conforme a concentração de fármaco (0 mg/ml, n = 9; 0,001 mg/ml, n = 7; 0,003 mg/ml, n = 7; e 0,006 mg/ml, n = 7). A droga foi administrada por via hídrica em 86 ml de água por 180 segundos. Para EI, foi utilizado um aquário dividido em dois compartimentos, um preto e um branco, por uma porta corrediça, sendo o animal inicialmente colocado no compartimento preto. Após 180 s, a porta foi removida e o tempo de travessia para o compartimento branco foi registrado (latência), cada travessia correspondendo a uma tentativa, sendo sete no total. Os dados foram analisados por ANOVA de duas vias seguida do teste de Dunnet. Os resultados indicaram diferença estatisticamente significativa na latência entre as tentativas, com aumento da latência. O teste de Dunnet mostrou diferença significativa entre as tentativas 1 e 6 e 1 e 7 e entre os grupos controle e grupo com a concentração de 0,006 mg/ml. Os dados indicam: 1) redução do valor aversivo do lado branco, o que demonstra o efeito ansiolítico do clonazepam; e 2) que o clonazepam não impediu a esquiva inibitória. Palavras-chave: esquiva inibitória, clonazepam, Carassius auratus.

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The Development and Evaluation of a New Aerosol Irritant Assay with Minimal Animal Stress

Karwowski

MacLeod

Quastel

2001

Pulmonary Pharmacology & Therapeutics

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Current aerosol irritant assays trap animals in noxious atmospheres and put a lot of stress on them. For this reason, the Minimal Animal Stress Irritant Assay Chamber (MASIAC) was developed based on the principle of avoidance, and evaluated. The MASIAC reproducibly detected citric acid with more sensitivity than conventionally used assays. With a group of mice tested simultaneously, the responses were not significantly affected by the presence of other mice. In addition, following multiple exposures to citric acid, the mice either sensitized to the irritant, or learned to avoid it. This suggests a number of areas where the MASIAC could be applied, including behavioral and asthma research. If this new method turns out to be as good as currently used assays, it could provide investigators with an alternative, more humane method of evaluating pulmonary irritants.

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Comparative effects of carbamazepine, phenytoin, diazepam and clonazepam on inhibitory avoidance learning in mice

Cited by 9 publications

References 27 publications

The antimanic‐like effect of phenytoin and carbamazepine on methylphenidate‐induced hyperlocomotion: role of voltage‐gated sodium channels

The antimanic‐like effect of phenytoin and carbamazepine on methylphenidate‐induced hyperlocomotion: role of voltage‐gated sodium channels

Efeitos Do Clonazepam Na Esquiva Inibitória No Peixe-Dourado (Carassius Auratus)

The Development and Evaluation of a New Aerosol Irritant Assay with Minimal Animal Stress

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