Comparative effects of Citrullus colocynthis, sunflower and olive oil-enriched diet in streptozotocin-induced diabetes in rats

Effects of hydro-ethanol extract of Citrullus colocynthis on blood glucose levels and pathology of organs in alloxan-induced diabetic rats

“…These findings reveal that the anti-hyperglycemic effect of C. colocynthis is not only through the insulin-like substances such as saponin present in this plant or activation of the insulin receptors, but this planet is able to increase the number of the B cells in the islets of Langerhans which results in a higher production of insulin. Sebbagh et al showed that 16 d after administration of this seed extract, glycaemia in the streptozotocin-induced diabetes in rats was reduced and stated that this effect could be related to the partial regeneration or preservation of the pancreatic B-cell mass after streptozotocin treatment in rats [6] .…”

“…The herbal drugs are prescribed widely because of their effectiveness, fewer side effects and relatively low cost and the traditional plant medicines are used throughout the world for a range of diabetic presentations [5] . Citrullus colocynthis (Cucurbitaceae) (C. colocynthis), commonly known as "bitter apple", "colosynth", "vine-of-sodom" and "tumba" is a well-known fruit traditionally used as an antidiabetic medication in the Mediterranean countries [6] . The ingredients of this plant may act on blood glucose through different mechanisms; some of them may have insulin's activity [7] .…”

Phytochemical screening and free radical scavenging activity of Citrullus colocynthis seeds extracts

“…The oil extract from C. colocynthis seeds is rich in unsaturated fatty acids (80%-85%), especially oleic acid (13.1%) and linoleic acid (70.1%) [11] . In streptozotocininduced diabetic rats, the inclusion of C. colocynthis oil in the diet opposes insulin resistance and increases the mass of pancreatic insulin producing 毬 -cells [13] .…”

Medicinal Plants from Jordan in the Treatment of Diabetes: Traditional Uses vs.In VitroandIn VivoEvaluations – Part 2

“…Hypoglycemic activity [95] Tertiary and quaternary alkaloids, glycoside and saponin components [101]. Phenolics and flavonoids [102] Hypoglycemic and antihyperglycemic effects in normal and alloxan diabetic rabbits [101] and STZ diabetic rats [103] by partly preserving or restoring pancreatic beta-cell mass [104] and insulinotropic effect [105]. Clinical beneficial effect on improving the glycemic profile without severe adverse effects in type 2 diabetic patients [106] continued next page Flavonoids: mainly myricetin [108].…”