Comparative effects of conventional hormone replacement therapy and tibolone on climacteric symptoms and sexual dysfunction in postmenopausal women

Ziaei, Saeideh; Moghasemi, Sedigheh; Faghihzadeh, Soghrat

doi:10.3109/13697130903009195

Cited by 28 publications

(15 citation statements)

References 23 publications

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“…Both, its 3a-OH metabolite (Org4094), and 3b-OH metabolite (Org30126) bind to estrogen receptor (ER) alpha, while its D-metabolite (OM38) binds to the androgen-(AR), and progesterone receptor (PR) 3 . The binding affinity of OM38 to the AR is high displaying an agonistic activity comparable to testosterone 4 , making it a treatment option for postmenopausal women also suffering from loss of libido 5 . Loss of libido may be associated with decreased serum androgens, e.g.…”

Section: Introductionmentioning

confidence: 99%

The impact of testosterone, tibolone and black cohosh on purified mammary and placental 17β-hydroxysteroid dehydrogenase type 1

Stute

Kalkhake

Kiesel³

et al. 2014

Journal of Enzyme Inhibition and Medicinal Chemistry

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Context: Mammary and placental 17b-hydroxysteroid dehydrogenase type 1 (17bHSD1). Objective: To assess the impact of testosterone, tibolone, and black cohosh on purified mammary and placental 17bHSD1. Materials and methods: 17bHSD1 was purified from human mammary gland and placenta by column chromatography, its activity was monitored by a radioactive activity assay, and the degree of purification was determined by gel electrophoresis. Photometric cofactor transformation analysis was performed to assess 17bHSD1 activity without or in presence of testosterone, tibolone and black cohosh. Results: 17bHSD1 from both sources displayed a comparable basal activity. Testosterone and tibolone metabolites inhibited purified mammary and placental 17bHSD1 activity to a different extent, whereas black cohosh had no impact. Discussion: Studies on purified enzymes reveal the individual action of drugs on local regulatory mechanisms thus helping to develop more targeted therapeutic intervention. Conclusion: Testosterone, tibolone and black cohosh display a beneficial effect on local mammary estrogen metabolism by not affecting or decreasing local estradiol exposure.

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Section: Introductionmentioning

confidence: 99%

The impact of testosterone, tibolone and black cohosh on purified mammary and placental 17β-hydroxysteroid dehydrogenase type 1

Stute

Kalkhake

Kiesel³

et al. 2014

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…Es zeigtesich aber auch,d assT ibolon im Vergleich zu der Kombinationstherapie aus CEE und MPAd en SHBG-Spiegel signifikant absenkte und es damit zu einem deutlichen Anstieg desf reien Testoste-█ Korrekturexemplar: Veröffentlichung (auch online), Vervielfältigung oder Weitergabe nicht erlaubt! █ ron-Index bzw.d es freien und damit biologischw irksamen Testosterons kam (Ziaei et al 2010) -eine Veränderung,d ie die beobachteten Unterschiede möglicherweise bereits erklärt. Interessant sind insoferna uchd ie Ergebnisse einer weiterenS tudie, die 2,5 mg Tibolon mit einer transdermalen Hormontherapie,bestehend aus 50 µg Östradiol /Tag und 140 µg NETA / Tag (E2 /NETA) bei 403 postmenopausalen Frauen mit sexueller Dysfunktion vergleicht.…”

Section: Tibolonunclassified

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Schwenkhagen¹

2011

Z Sex-Forsch

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Übersicht: Sexuelle Störungen bei Frauen sind im klinischen Alltagein häu-figesP roblem. Bisher stehen jedoch nur wenige Medikamente zur Behandlung dieser Probleme zur Verfügung. Hauptzield er Forschung ist heute die Entwicklungv on Medikamenten, mit deren Hilfedas bei Frauen im Vordergrund stehende Problem einer Libidostörung gebessert werden könnte.I m Fokus desI nteresses stehen dabei einerseits Sexualsteroide,a ndererseits zentral wirksame Substanzen. Eine konventionelle systemische und/oder lokale Östrogenbehandlung kann in der Postmenopause helfen, östrogen-mangelbedingtev ulvovaginaleP robleme zu behandeln und die sexuelle Funktion wiederherzustellen. Oftr eicht eine solche Therapie allein nicht aus. Neuere Studien zeigen, dassA ndrogene als unabhängige Faktorenf ür Libido, sexuelle Aktivitätu nd sexuelle Zufriedenheit vongroßer Bedeutung sind. Es liegen überzeugende Datenvor, dassFrauen mit einem eindeutigen Androgenmangel,z .B.i nfolge einer beidseitigen Adnexektomie, vone iner Testosterontherapie profitieren. Dies gilt auch fürF rauen, die auf natürli-chem Wegi nd ie Wechseljahre gekommen sind. Zurzeit gibt es nochk eine belastbare wissenschaftlicheGrundlage füreine systemische Therapie sexueller Funktionsstörungen mit dem Nebennierenrindenhormon Dehydroepiandrosteron (DHEA).Vielversprechend sind jedoch erste Studien zum lokalen Einsatz vonD HEAb ei vaginalenA trophiesymptomen. Seit einigen Jahren wirda uch intensiv daran geforscht, zentralwirksame Substanzen zu entwickeln, die positiveE ffekte auf die Sexualfunktion bei Frauen haben könnten. Dazug ehören u. a. Substanzen, die den Serotonin-Noradrenalinund Dopaminstoffwechselb eeinflussenk önnen.

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“…This section was only answered by those individuals who identified themselves as in menopause or post menopause. Several studies have utilized this scale to measure climacteric symptoms (Ziaei, Moghasemi, & Faghihzadeh, 2009;Barentsen, van de Weijer, van Gend, & Foekema, 2001;McPhail & Smith 2000). Good test-retest reliability was found with coefficients ranging from 0.83 to 0.87 (Greene, 1998;Green, 1976).…”

Section: Women's Healthmentioning

confidence: 99%

Reliability of a Health Questionnaire Among Women With Brain Injury

Colantonio

Harris

Tarek

2011

Journal of Neuroscience Nursing

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Research on health outcomes post traumatic brain injury (TBI) has found women have unique issues in comparison to men. However, no tools have been developed to capture these unique health outcomes. We investigated rater agreement of a health questionnaire developed to identify health concerns among women with TBI. Thirteen women completed the questionnaire twice and provided feedback regarding content and ease of use. Kappa coefficients and percent agreement were generated to determine level of response agreement. Kappa coefficients ranged from 0.21 to 1.00 with the highest agreement for items requiring concrete responses (e.g. yes/no) and the lowest with items requiring more subjective answers. Participants rated the utility of the questionnaire high (73%-100%). This questionnaire proved to be a reliable and useful method to gather information regarding health in women with TBI. By identifying health issues early, diagnostic and treatment intervention may be delivery in a timelier and effective manner. Post-Print version

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Comparative effects of conventional hormone replacement therapy and tibolone on climacteric symptoms and sexual dysfunction in postmenopausal women

Abstract: Tibolone may be an alternative to conventional hormone replacement therapy in the treatment of climacteric symptoms and sexual dysfunction in postmenopausal women.

Cited by 28 publications

References 23 publications

The impact of testosterone, tibolone and black cohosh on purified mammary and placental 17β-hydroxysteroid dehydrogenase type 1

The impact of testosterone, tibolone and black cohosh on purified mammary and placental 17β-hydroxysteroid dehydrogenase type 1

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Reliability of a Health Questionnaire Among Women With Brain Injury

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