2015
DOI: 10.1097/md.0000000000001349
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Comparative Effects of Dexmedetomidine and Propofol on US-Guided Radiofrequency Ablation of Hepatic Neoplasm Under Monitored Anesthesia Care

Abstract: Percutaneous radiofrequency ablation (RFA) is a useful and safe procedure for treating hepatic neoplasm. However, liver RFA causes severe pain, which thereby increases the demand for monitored anesthesia care (MAC). Here, we compared the efficacy and safety of propofol and dexmedetomidine, which are commonly administered during MAC when performing RFA to assess hepatic neoplasm.In this randomized controlled trial, 40 patients were randomly allocated to 2 groups for elective RFA. Patients received either dexmed… Show more

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Cited by 18 publications
(28 citation statements)
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“…These patients can be managed with sedatives and opioids effectively. [3] In our patient, BP, HR, and SPI increased after initiation of RFA. Although patients treated with transthoracic approach do not feel any discomfort because of general anesthesia, analgesic drug concentration should be modulated through vital signs and SPI values during procedure.…”
Section: Discussionmentioning
confidence: 58%
See 1 more Smart Citation
“…These patients can be managed with sedatives and opioids effectively. [3] In our patient, BP, HR, and SPI increased after initiation of RFA. Although patients treated with transthoracic approach do not feel any discomfort because of general anesthesia, analgesic drug concentration should be modulated through vital signs and SPI values during procedure.…”
Section: Discussionmentioning
confidence: 58%
“…The percutaneous approach is the most common approach for RFA application and can be done under monitored anesthesia care. [3] The laparoscopic approach and laparotomy can also be used under general anesthesia. [4,5] However, hepatic tumors that located immediately beneath the diaphragm are difficult to treat with percutaneous RFA due to poor visualization by percutaneous ultrasonography (US) and the close location of the heart or lung.…”
Section: Introductionmentioning
confidence: 99%
“…One-way repeated analysis of variance (within factors: no Thera-Band, occiput, and thoracic region) was used to assess the statistical significance of RA activity, TKA, SA activity, and SW by using PASW Statistics 23 (SPSS, Chicago, IL). [ 35 ] The significance level was set at α = 0.05. If a significant difference was found, Bonferroni adjustment was performed (with α = 0.05/3 = 0.017).…”
Section: Methodsmentioning
confidence: 99%
“…One-way repeated analysis of variance of the within-subject factors (no cue, tactile cue to TSP, and tactile cue to ISR) was used to assess the statistical significance of TES, RA, LT, SA, and UT EMG activities; scapular winging; and thoracic kyphosis using PASW Statistics 18 (SPSS, Chicago, IL). [ 25 ] The level of significance was set at α = 0.05. We used Bonferroni correction for the pairwise comparisons when significant differences were detected (α = 0.05/3).…”
Section: Methodsmentioning
confidence: 99%