Comparative effects of dimethoate and deltamethrin on reproductive system in male mice

Abdallah, Ferjani Ben; Slima, Ahlem Ben; Dammak, Ines; Keskes, Leila; Mallek, Z.

doi:10.1111/j.1439-0272.2009.00976.x

Cited by 28 publications

(16 citation statements)

References 10 publications

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“…Variation among studies may be attributed to the difference in the doses and experiment design. Moreover, the negative impact of DM-intoxication on spermatogenic and androgenic activity that was observed in the current study is comparable with the results of previous studies that applied different doses and regimens in rat and mice (Al-Amoudi, 2016;Ben Abdallah et al, 2010;Ben Halima et al, 2014;Ben Slima et al, 2013;Oda & El-maddawy, 2012). Deltamethrin-intoxication might alter the testosterone production either through a direct effect on Leydig cells (Zhang et al, 2007) or decreasing the LH level (Al-Amoudi, 2016).…”

Section: Discussionsupporting

confidence: 91%

“…Lower testicular and epididymal weights in DM-intoxicated rats recorded in the current study comes in agreement with previous reports (Oda & El-maddawy, 2012) but in disagreement with other reports (Ben Abdallah, Ben Slima, Dammak, Keskes-Ammar, & Mallek, 2010). Variation among studies may be attributed to the difference in the doses and experiment design.…”

Section: Discussionsupporting

confidence: 71%

“…Moreover, the negative impact of DM-intoxication on spermatogenic andandrogenic activity that was observed in the current study is comparable with the results of previous studies that applied different doses and regimens in rat and mice(Al-Amoudi, 2016;Ben Abdallah et al, 2010;Ben Halima et al, 2014;Ben Slima et al, 2013;Oda & El-maddawy, 2012). Variation among studies may be attributed to the difference in the doses and experiment design.…”

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confidence: 90%

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Chlorella vulgaris ameliorates testicular toxicity induced by deltamethrin in male rats via modulating oxidative stress

et al. 2018

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This study was carried out to investigate the potential effects of Chlorella vulgaris (CV) on testicular function and oxidant/antioxidant status in normal and deltamethrin‐intoxicated rats. Forty adult male rats were drenched either with normal saline, CV (50 mg/kg), deltamethrin (DM) (3 mg/kg), or CV combined with DM, daily for 8 weeks. At the end of the protocol, the epididymal sperm quality was evaluated and the testicular superoxide dismutase (SOD), catalase enzyme (CAT) and malondialdehyde (MDA), and the serum testosterone levels were estimated. Normal rats treated with CV showed a significant increase in the total sperm number/epididymal tail, testicular SOD, and CAT levels with a significant decrease in the testicular MDA. Deltamethrin intoxication significantly decreased the proportions of motile and live sperm, the testosterone concentration, the testicular SOD and CAT levels, whereas it significantly increased the proportion of abnormal sperm and the testicular MDA. Chlorella vulgaris treatment significantly ameliorated the adverse effects of DM‐intoxication and restored most of the parameters to levels that are comparable to those of the control group. In conclusion, CV administration improved the testicular function of normal rats and ameliorated the effect of severe oxidative stress conditions.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 71%

supporting

confidence: 90%

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Chlorella vulgaris ameliorates testicular toxicity induced by deltamethrin in male rats via modulating oxidative stress

et al. 2018

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“…Dimethoate at 28 mg kg −1 was associated with a significant decreased of sperm count, mobility and viability and significantly increased the percent of morphologically abnormal spermatozoa compared with the controls (Abdallah et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Effect of Dimethoate (An Organophosphate Insecticide) on the Reproductive System and Fertility of Adult Male Rat

Ngoula¹

2014

American Journal of Pharmacology and Toxicology

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The pesticides are one of the most potentially harmful chemicals liberated in the environment in an unplanned manner. Dimethoate is widely used as a potent pesticide in many countries and has been shown to produce some adverse health effects. In the present study, we investigated the effect of dimethoate (an organophosphate insecticide) on the reproductive system and fertility of male rats and the possible mechanism underlining its action. Twenty four adult Wistar male rats were divided into 4 groups of 6 animals per group and force-fed with 0, 3.66, 5.50 and 11 mg kg −1 body weight of dimethoate for 90 days. At 80 days of treatment, each males was allows to mate with two primiparous cyclic females. The results showed a significant decrease (p<0.05) of body weight gain in rats gavaged with dimethoate compared to control. In addition, this insecticide at the doses of 3.66, 5.5 and 11 mg kg −1 caused a significant (p<0.05) increase of the relative weight of epididymis. Dimethoate at its highest dose caused a decrease in the relative weights of testes and ventral prostate. The doses 3.66, 5.50 and 11.00 mg kg −1 body weight of dimethoate caused a significant decrease (p<0.05) of the sperm concentration and motility. The level of protein and cholesterol in the serum and testes as well as the activity of prostatic acid phosphatase decreased significantly (p<0.05) in rats treated with dimethoate compared to control. Fertility, gestation and parturition indices as well as the litter size decreased significantly in animals treated with 5.50 and 11.00 mg kg −1 body weight of dimethoate compared to control. The testicular histology of animals treated with high doses of dimethoate generally showed span of Sertoli cells destruction and disorganization of the germinal epithelium. The lumen of seminiferous tubules of treated rats was generally poor in sperm. The results of this study confirmed that dimethoate seriously deteriorate the male reproductive system resulting in decreased fertility.

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“…Dimethoate at 28 mg kg −1 day −1 , deltamethrin at 5 mg kg −1 day −1 and their mixture at 5 mg kg −1 day −1 were associated with a significantly decreased sperm count, motility and viability and significantly increased percent morphologically abnormal spermatozoa (Abdallah et al, 2010). Subchronic exposure of male rat to dimethoate (2, 8 and 20 mg/kg for 90 days) induced a decrease in relative testis weights (Sayým, 2007).…”

Section: Effects Of Organophosphate Insecticides On Male Reproductivementioning

confidence: 99%

Reproductive and Developmental Toxicity of Insecticides

Ngoula¹,

Ngouateu²,

Raphaël³

et al. 2012

Insecticides - Advances in Integrated Pest Management

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Comparative effects of dimethoate and deltamethrin on reproductive system in male mice

Cited by 28 publications

References 10 publications

Chlorella vulgaris ameliorates testicular toxicity induced by deltamethrin in male rats via modulating oxidative stress

Chlorella vulgaris ameliorates testicular toxicity induced by deltamethrin in male rats via modulating oxidative stress

Effect of Dimethoate (An Organophosphate Insecticide) on the Reproductive System and Fertility of Adult Male Rat

Reproductive and Developmental Toxicity of Insecticides

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