Comparative effects of incretin-based therapy on early-onset diabetic nephropathy in rats: Role of TNF-α, TGF-β and c-caspase-3

Habib, Heba A.; Heeba, Gehan H.; Khalifa, Mohamed M.

doi:10.1016/j.lfs.2021.119624

Cited by 12 publications

(8 citation statements)

References 64 publications

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“…The diagnostic criteria of western medicine are as follows: refer to the diagnostic criteria of DN in the guidelines for diagnosis and treatment of DN [ 11 ].…”

Section: Methodsmentioning

confidence: 99%

Clinical Application of the Classical Theory of Traditional Chinese Medicine in Diabetic Nephropathy

Pan

Shi

2022

Computational and Mathematical Methods in Medicine

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Objective. To explore the clinical application of the classical theory of traditional Chinese medicine (TCM) in diabetic nephropathy (DN). Methods. A total of 100 patients with DN treated in our hospital from May 2019 to June 2021 were included. The patients were randomly assigned to the control group and the study group. The control group received routine treatment, and the study group was treated with the classical theory of TCM. The efficacy, TCM syndrome score, urine proteinuria (UTP), urine albumin-creatinine ratio (UACR), plasma albumin (ALB), hemoglobin A1c (HbA1C), fasting blood glucose (FBG), blood urea nitrogen (BUN), creatinine (Cr), and treatment safety were compared between the two groups. Results. In comparison to the curative effect, the study group was significantly effective in 34 cases, effective in 12 cases, and ineffective in 4 cases, and the effective rate was 92.00%; the control group was significantly effective in 16 cases, effective in 18 cases, and ineffective in 16 cases, and the effective rate was 68.00%. The effective rate in the study group was higher compared to the control ( P < 0.05 ). In comparison to the TCM syndrome scores, there exhibited no significant difference before treatment ( P > 0.05 ), but after treatment, the TCM syndrome scores of the two groups decreased, and the TCM syndrome scores of the study group were lower compared to the control at 6 weeks, 12 weeks, 24 weeks, and 36 weeks of treatment ( P < 0.05 ). There exhibited no significant difference in the indexes of UTP and UACR before treatment, but the indexes of UTP and UACR in the two groups decreased after treatment, and the indexes of UTP and UACR in the study group were lower compared to the control at 6 and 12 weeks after treatment. There was no significant difference in the indexes of ALB, HbA1C, and FBG before treatment, but after treatment, the indexes of ALB increased, the indexes of HbA1C and FBG decreased in both groups, and the indexes of HbA1C and FBG i4n the study group were lower compared to the control, while the index of ALB in the study group was higher. The indexes of BUN and Cr were compared, and there was no significant difference before treatment, but after treatment, the indexes of BUN and Cr in the two groups decreased, and the indexes of BUN and Cr in the study group were lower compared to the control ( P < 0.05 ). In terms of the treatment safety of the two groups, there was no abnormality in blood, urine, stool routine, and liver and kidney function examination in the study group. No obvious adverse reactions were found in all patients. There were 1 case of abnormal liver function and 2 cases of rash in the control group, and there exhibited no significant difference ( P > 0.05 ). Conclusion. Under the guidance of classical theory, the optimization scheme of comprehensive treatment of TCM may improve renal function by improving metabolic disorders, vascular lesions, neurotrophic disorders, antioxidant stress, and other ways to repair nerve injury, improving the changes of TCM syndromes, signs, and indicators of patients, and delay the progress of DN.

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“…The diagnostic criteria of western medicine are as follows: refer to the diagnostic criteria of DN in the guidelines for diagnosis and treatment of DN [ 11 ].…”

Section: Methodsmentioning

confidence: 99%

Clinical Application of the Classical Theory of Traditional Chinese Medicine in Diabetic Nephropathy

Pan

Shi

2022

Computational and Mathematical Methods in Medicine

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“…In renal inflammatory diseases, TGF-β has been demonstrated to orchestrate the differentiation of T cells, including Th17 and Foxp3 + Treg cells ( 96 ) Additionally, rats with hyperglycemia-induced microalbuminuria possess upregulated TGF-β and serum creatinine levels ( 115 ). Recently, the role of TGF-β in promoting the characterized T cell cytokines, IL-9 and IL-17, has become more widely accepted.…”

Section: Recruitment and Activation Of T Cells In Diabetic Kidney Dis...mentioning

confidence: 99%

T cells and their products in diabetic kidney disease

Liu

Zhang

et al. 2023

Front. Immunol.

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Diabetic kidney disease (DKD) is the most common cause of end-stage renal disease and has gradually become a public health problem worldwide. DKD is increasingly recognized as a comprehensive inflammatory disease that is largely regulated by T cells. Given the pivotal role of T cells and T cells-producing cytokines in DKD, we summarized recent advances concerning T cells in the progression of type 2 diabetic nephropathy and provided a novel perspective of immune-related factors in diabetes. Specific emphasis is placed on the classification of T cells, process of T cell recruitment, function of T cells in the development of diabetic kidney damage, and potential treatments and therapeutic strategies involving T cells.

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“…The rats were allocated into two dietary regimens by feeding either a normal pellet diet (NPD) to the control rats or a high fat diet (HFD) (58% fat, 25% protein and 17% carbohydrate, as a percentage of total kcal) for the induction of diabetic rats. Diet composition followed that of Habib et al (2021).…”

Section: Induction Of Type II Diabetes Mellitus In Ratsmentioning

confidence: 99%

Testicular cytoprotective effect of glucagon like peptide-1 in diabetic rats involves inhibition of apoptosis, endoplasmic reticulum stress and activation of autophagy

Abdel-Hakeem¹,

Zenhom²,

Mokhemer³

2023

gpb

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This study aimed to explore the possible cytoprotective effects of exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist, in the testicles of diabetic rats. Exenatide has numerous advantageous properties in addition to its hypoglycemic effect. However, its impact on testicular tissue in diabetes needs more clarification. Therefore, rats were divided into control, exenatide-treated, diabetic and exenatide-treated diabetic groups. Blood glucose and serum levels of insulin, testosterone, pituitary gonadotropins and kisspeptin-1 were measured. Real-time PCR for beclin-1, p62, mammalian target of rapamycin (mTOR), and AMP-activated protein kinase (AMPK), were estimated in testicular tissue in addition to markers of oxidative stress, inflammation, and endoplasmic reticulum stress. Also, immuno-expression of protein P53, nuclear erythroid factor2 (Nrf2) and vimentin was conducted. Exenatide was able to attenuate diabetic toxic changes and enhance autophagy in testicular tissue. These results indicate the protective effect of exenatide against diabetic testicular dysfunction.

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Comparative effects of incretin-based therapy on early-onset diabetic nephropathy in rats: Role of TNF-α, TGF-β and c-caspase-3

Cited by 12 publications

References 64 publications

Clinical Application of the Classical Theory of Traditional Chinese Medicine in Diabetic Nephropathy

Clinical Application of the Classical Theory of Traditional Chinese Medicine in Diabetic Nephropathy

T cells and their products in diabetic kidney disease

Testicular cytoprotective effect of glucagon like peptide-1 in diabetic rats involves inhibition of apoptosis, endoplasmic reticulum stress and activation of autophagy

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