Comparative Effects of Methylene, Ethylene and Propylene Dimethanesulphonates on the Male Rat Reproductive System

Cooper, E. R. A.; Jackson, Helen C.

doi:10.1530/jrf.0.0230103

Cited by 50 publications

(27 citation statements)

References 7 publications

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“…The vasa efferentia in the rat and mouse 319 side, the testis and epididymis were removed. Later, after spermatogenesis had recovered (Cooper & Jackson, 1970) …”

Section: Undertakenmentioning

confidence: 99%

The Vasa Efferentia in the Rat and Mouse

Cooper¹,

Jackson²

1972

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According to Wakeley (1943-44), the majority of epididymal cysts in man arise in the vasa efferentia, the bridge of tissue between the testis and epididymis. The ability of two sterilant chemicals to produce specific lesions of this nature in the rat (\g=a\-chlorhydrin\p=m-\Ericsson,1970; ethylenedimethanesulphonate\p=m-\Cooper & Jackson, 1970) points to the need for further information on the vasa efferentia in relation to their susceptibility to damage in this manner. As there appears to be inadequate information on the course of these tubules, the present study was undertaken.At post mortem, the testes resting in the scrotum of the rat present anterior and posterior surfaces and medial and lateral rounded borders. Serial longitudinal sections were made in both rat and mouse of the entire testis-epididymisvas complex, from the anterior to the posterior surface. In sections from a number of rats, it was observed that the rete testis penetrates into the tunica albuginea and from it, two channels of vasa efferentia emerge (Pl. 1 , Fig. 1); the arrangement is similar in the mouse (Pl. 1, Fig. 4). In the rat, both tubules become convoluted in relation to a non-tortuous artery and vein, which are branches of the superior epididymal vessels. The two channels and the blood vessels ascend in a column of fat covered by a peritoneal layer, inclining slightly laterally and posteriorly. In its ascent, each passes behind the caput epididymidis to a variable distance above it. There, the tubules arch medially and anteriorly (the arch, PI. 1, Figs. 2 and 3) and gain the upper margin of the proximal caput into which the vasa efferentia become incorporated (PI. 1, Fig. 3). It is at the arch that the nutrient vessels join the tubules from the lateral aspect. The vasa efferentia are relatively large at their origin from the rete testis (PI. 2, Figs. 5 and 6) and become smaller as they approach their union with the caput. A single layer of cubical to columnar epithelium supported by delicate fibres forms the wall, while stroma envelops them. Invariably, the vasa are empty in sections of normal specimens.According to Cunningham (1928), the vasa efferentia of the rat leave the testis, pass dorsal to the epididymis and join the anterior lobe of the caput. Harrison (1953)

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“…The vasa efferentia in the rat and mouse 319 side, the testis and epididymis were removed. Later, after spermatogenesis had recovered (Cooper & Jackson, 1970) …”

Section: Undertakenmentioning

confidence: 99%

The Vasa Efferentia in the Rat and Mouse

Cooper¹,

Jackson²

1972

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“…It frequently induces pathological changes in the epididymis, culminating in cyst formation in this duct on one or both sides (Cooper & Jackson, 1970). Ericsson (1970) found that a-chlorhydrin (U-5897) caused cysts in the rat, specifically in the ductuli efferentes and initial part of the caput epididymidis, which led to permanent sterility.…”

Section: Introductionmentioning

confidence: 99%

Chemically Induced Sperm Retention Cysts in the Rat

Cooper¹,

Jackson²

1973

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“…This observation naturally led to an investigation of how far the antispermatogenic and antifertility actions of this compound involved the endocrine system, particularly the production and secretion of androgen. Treatment with EDS also inhibits the spermatogenic process in the mouse (Cooper & Jackson, 1970), in Japanese quail (Jones, Kominkova & Jackson, 1972) and in the parasitic worm, Schistosoma mansoni (Davies & Jackson, 1970).…”

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confidence: 98%

“…In this species, administration of ethylenedimethanesulphonate (EDS) is accompanied by a temporary involution of both the ventral prostate and the seminal vesicles (Cooper & Jackson, 1970). This observation naturally led to an investigation of how far the antispermatogenic and antifertility actions of this compound involved the endocrine system, particularly the production and secretion of androgen.…”

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confidence: 99%