Comparative Effects of Morphine, Meperidine, and Pentazocine on Cardiocirculatory Dynamics in Patients With Acute Myocardial Infarction

The Hemodynamic Effects of Intravenous Bolus Doses of Meperidine in Conscious Sheep

“…With large doses, these drugs can induce direct negative chronotropic and negative inotropic effects on the heart after a transient excitation which is mediated through effects of opioid analgesics on the CNS and autonomic nervous system (1,6,26). Despite these conflicting results and the fact that meperidine is widely used clinically for the management of pain (24,27), the myocardial effects of meperidine have not been studied in conscious, unpremedicated animals. The experiments described in this paper were designed to study the myocardial effects of meperidine in animals with uncompromised central and autonomic nervous system functions and without the influences of surgery or any premedication as is found in most animal experiments.…”

National Heart Foundation of Australia and Cardiac Society of Australia and New Zealand: Guidelines for the Prevention, Detection, and Management of Heart Failure in Australia 2018

“…Benefits and harms: In patients who are distressed or agitated, opiates may relieve symptoms, induce venodilatation, mild arterial dilatation, and reduce heart rate [134]. These potential symptomatic effects should be weighed against the risk of hypotension, respiratory depression, and nausea (with the potential for aspiration), all of which may increase the need for invasive ventilation.…”

Острая Сердечная Недостаточность: Рекомендациипо Диагностике И Лечению

“…По данным нескольких ретроспективных иссле дований, при катетеризации ЛА у пациентов с ОИМ было выявлено увеличение смертности у больных с катетеризацией ЛА [68][69][70]. Эти наблюдения час тично объясняются различиями между исследуемы ми (смешанными) группами [70][71][72][73].…”