Comparative effects of nebivolol and metoprolol on oxidative stress, insulin resistance, plasma adiponectin and soluble P-selectin levels in hypertensive patients

Çelik, Turgay; İyisoy, Atila; Kurşaklıoğlu, Hürkan; Kardeşoğlu, Ejder; Kılıç, Selim; Turhan, Hasan; Yılmaz, Mahmut İlker; Özcan, Ömer; Yaman, Halıl; Işık, Ersoy; Fıcı, Francesco

doi:10.1097/01.hjh.0000209993.26057.de

Cited by 174 publications

(122 citation statements)

References 37 publications

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“…Nebivolol, which is more selective for the β1 versus the β2 receptor than metoprolol, produces similar effects to metoprolol on the heart (Grassi et al 2003;Rozec et al 2006). Nebivolol also improves oxidative stress, insulin sensitivity, and plasma soluble P-selectin and adiponectin levels in hypertensive patients (Celik et al 2006;Rozec et al 2006). These effects may be due to offtarget activation of the α 1 -adrenergic receptor (Celik et al 2006;Rozec et al 2006).…”

Section: Introductionmentioning

confidence: 98%

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β1-Adrenergic receptor blockade extends the life span of Drosophila and long-lived mice

Spindler

Mote

et al. 2013

AGE

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Chronic treatment with β-adrenergic receptor (βAR) agonists increases mortality and morbidity while βAR antagonists (β-blockers) decrease allcause mortality for those at risk of cardiac disease. Levels of sympathetic nervous system βAR agonists and βAR activity increase with age, and this increase may hasten the development of age-related mortality.Here, we show that β-blockers extend the life span of healthy metazoans. The β-blockers metoprolol and nebivolol, administered in food daily beginning at 12 months of age, significantly increase the mean and median life span of isocalorically fed, male C3B6F1 mice, by 10 and 6.4 %, respectively (P< 0.05). Neither drug affected the weight or food intake of the mice, indicating that induced CR is not responsible for these effects, and that energy absorption and utilization are not altered by the drugs. Both β-blockers were investigated to control for their idiosyncratic, off-target effects. Metoprolol and nebivolol extended Drosophila life span, without affecting food intake or locomotion. Thus, βAR antagonists are capable of directly extending the life span of two widely divergent metazoans, suggesting that these effects are phylogenetically highly conserved. Thus, long-term use of β-blockers, which are generally well-tolerated, may enhance the longevity of healthy humans.

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Section: Introductionmentioning

confidence: 98%

“…Nebivolol also improves oxidative stress, insulin sensitivity, and plasma soluble P-selectin and adiponectin levels in hypertensive patients (Celik et al 2006;Rozec et al 2006). These effects may be due to offtarget activation of the α 1 -adrenergic receptor (Celik et al 2006;Rozec et al 2006).…”

Section: Introductionmentioning

confidence: 99%

β1-Adrenergic receptor blockade extends the life span of Drosophila and long-lived mice

Spindler

Mote

et al. 2013

AGE

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“…Also, to clarify the contribution of oxidative stress to the association of the CSX disease, we evaluated the SOD activity in CSX patients and controls because SOD has been reported to be the major antioxidant enzyme system of the arterial vessel wall 26 . In this study, SOD activity was significantly lower CSX patients than in controls individuals.…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress status in patients with cardiac syndrome X

Seydi-Shirvani¹,

Rasmi

Seyyed-Mohammadzad³

et al. 2012

ScienceAsia

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Cardiac syndrome X (CSX) is characterized by chest pain, typical angina pectoris, abnormal exercise test result and normal coronary arteries. Microvascular dysfunction and enhanced oxidative stress are the mechanisms suspected to play an important role in the pathogenesis of CSX. Thus we aimed to evaluate the oxidative stress status of 28 patients with CSX (14 male/14 female, mean age 49.5 ± 9.3 years) and 24 age-and gender-matched healthy controls (10 male/14 female, mean age 45.6 ± 5.7 years). Blood samples were drawn for measurement of malodialdehyde (MDA), as a marker of lipid peroxidation, glutathione (GSH) and superoxide dismutase (SOD) activity, as antioxidant markers and ferric reducing ability of plasma (FRAP), as a marker of total antioxidant capacity. There was significant increase in the levels of MDA in CSX patients comparing to controls (3.8 ± 0.12 vs 3.3 ± 0.14 mM, respectively; p = 0.006). But the levels of FRAP in CSX patients were significantly lower than those controls (504 ± 19 vs 568 ± 26 µM, respectively; p = 0.046). Also, GSH levels and SOD activity in patients were significantly lower than those of the controls (GSH: 133.6 ± 5.4 vs 152.5 ± 7.8 mmol/g Hb, p = 0.048; SOD: 386 ± 34 vs 578 ± 38 U/g Hb, p = 0.0001). It may be concluded that there is systemic oxidative stress in CSX patients. Considerable changes of antioxidant concentrations, indicating a compensatory mechanism to cope with increased oxidative stress in CSX patients and the body's antioxidant defence mechanisms try to minimize oxidative stress damage.

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“…Высокая клиническая эффективность небиво-лола при различных сердечно-сосудистых заболе-ваниях -АГ, ИБС, в том числе у больных с СД на сегодняшний день имеет большую доказатель-ную базу -более 70 исследований [30][31][32][33][34][35].…”

Section: российский кардиологический журнал № 4 (102) | 2013unclassified

Combination antihypertensive therapy in patients with arterial hypertension and coronary heart disease

Морозова¹,

Андрущишина²

2013

Russ J Cardiol

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The leading positions in the treatment of patients with arterial hypertension (AH) and coronary heart disease (CHD) are held by angiotensin-converting enzyme (ACE) inhibitors and beta-adrenoblockers (BAB), which have demonstrated their effectiveness in terms of improved patients' survival. In patients with AH and CHD, the rational, pathogenetic pharmacotherapy using a combination of an ACE inhibitor zofenopril and a highly cardio-selective and vasodilating BAB nebivolol demonstrates antihypertensive and antiischemic action, decreases the risk of potential adverse cardio-metabolic effects, reduces the severity of endothelial dysfunction, and, consequently, improves quality of life. Russ J Cardiol 2013, 4 (102): 88-94

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Comparative effects of nebivolol and metoprolol on oxidative stress, insulin resistance, plasma adiponectin and soluble P-selectin levels in hypertensive patients

Cited by 174 publications

References 37 publications

β1-Adrenergic receptor blockade extends the life span of Drosophila and long-lived mice

β1-Adrenergic receptor blockade extends the life span of Drosophila and long-lived mice

Oxidative stress status in patients with cardiac syndrome X

Combination antihypertensive therapy in patients with arterial hypertension and coronary heart disease

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