Comparative effects of respiratory stimulants on hypoxic neuronal cell injury in SH‐SY5Y cells and in hippocampal slice cultures from rat pups

Abstract

Caffeine significantly attenuated cell injury induced by hypoxia in SH-SY5Y cells and hippocampal slice cultures of rat pups, at least partly through A2A R antagonism. Caffeine can protect neuronal cells from injury induced by hypoxemia, and may be a beneficial treatment for AOP with neuroprotective potential.