Comparative Effects of Some Medicinal Plants:Anacardium occidentale, Eucalyptus globulus, Psidium guajava,andXylopia aethiopicaExtracts in Alloxan-Induced Diabetic Male Wistar Albino Rats

Abstract

Insulin therapy and oral antidiabetic agents/drugs used in the treatment of diabetes mellitus have not sufficiently proven to control hyperlipidemia, which is commonly associated with the diabetes mellitus. Again the hopes that traditional medicine and natural plants seem to trigger researchers in this area is yet to be discovered. This research was designed to compare the biochemical effects of some medicinal plants in alloxan-induced diabetic male Wistar rats using named plants that are best at lowering blood glucose and hyperlipidemia and ameliorating other complications of diabetes mellitus by methods of combined therapy. The results obtained showed 82% decrease in blood glucose concentration after the 10th hour to the fortieth hour. There was significant increase P < 0.05 in the superoxide dismutase activity of the test group administered 100 mg/kg of A. Occidentale. There was no significant difference P > 0.05 recorded in the glutathione peroxidase activity of E. globulus (100 mg/kg) when compared to the test groups of P. guajava (250 mg/kg) and X. aethiopica (250 mg/kg). Catalase activity showed significant increase P < 0.05 in the catalase activity, compared to test groups. While at P > 0.05, there was no significant difference seen between test group and treated groups. Meanwhile, degree of significance was observed in other parameters analysed. The biochemical analysis conducted in this study showed positive result, attesting to facts from previous works. Though these individual plants extracts exhibited significant increase in amelorating diabetes complication and blood glucose control compared to glibenclamide, a synthetic antidiabetic drug. Greater performance was observed in the synergy groups. Therefore, a poly/combined formulation of these plants extracts yielded significant result as well as resolving some other complications associated with diabetics.

Protective Effect of Cashew Gum (Anacardium occidentale L.) on 5-Fluorouracil-Induced Intestinal Mucositis

“…Its bark, leaves, and bark oil are used in anti-inflammatory and astringent preparations for the treatment of diarrhea [21]. Previous studies using the extracts of cashew tree bark have reported hypoglycemic [22,23], antioxidant and anti-inflammatory [24], antimicrobial [25], antihypertensive [26], and anticancer effects. It also showed beneficial effects in the treatment of gastritis, diarrhea, and wounds [22,27].…”

“…Previous studies using the extracts of cashew tree bark have reported hypoglycemic [22,23], antioxidant and anti-inflammatory [24], antimicrobial [25], antihypertensive [26], and anticancer effects. It also showed beneficial effects in the treatment of gastritis, diarrhea, and wounds [22,27]. The anti-inflammatory activities and wound healing potential of cashew nuts have also been reported [28].…”

Phytopharmacological overview of Psidium guajava Linn.

“…The poly formulation of Anacardium occidentale, Eucalyptus globulus, P. guajava, and Xylopia aethiopica extracts yielded significant result as well as reduces some other complications associated with diabetes in alloxaninduced diabetic models. 78 Recently, aqueous extract of P. guajava leaves (250 and 500 mg/kg/d) re-set the raised circulating levels of leptin, insulin, and hepatic glucose transporter expression to promote insulin resistance, dyslipidemia, and hypertension in high fructose intake male rats.…”

Dietary Inclusion of a Mixed Powder of Medicinal Plant Leaves Enhances the Feed Efficiency and Immune Function in Broiler Chickens

“…Good examples of medicinal plants are Anacardium occidentale, Psidium guajava, and Morinda citrifolia. In this sense, the leaves of A. occidentale have astringent, antidiarrheal, antioxidant, and antimicrobial properties, due to the presence of polyphenols (mainly tannins) and coumarins [6]; its use in poultry and swine diets improves the growth performance and the production and quality of eggs and decreases the incidence of diarrhea, respectively [7]. Also, P. guajava, a plant of great application in the treatment of the diarrheic syndrome in pigs (mainly the leaves), has hypoglycemic, antioxidant, and antiinflammatory properties due to the presence of flavonoids (mainly gammapirons) and triterpenoids [8], and also its application as a medicinal drug in the diets of mice showed an antidiabetic effect [9].…”