Comparative effects of the anticholinesterase drug galanthamine on the mechanical activity of isolated rat jejunum and ileum

Mutafova‐Yambolieva, Violeta N.; Yamboliev, I.; Mihailova, D.

doi:10.1016/0306-3623(93)90377-a

Cited by 8 publications

(2 citation statements)

References 14 publications

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“…15 Their activation stimulates release of neurotransmitters like glutamine, serotonin, dopamine, GAPA and/or VIP etc. with SM effects diverse in character.…”

Section: On the Frequency Of Phasic Contractionsmentioning

confidence: 99%

Effect of Elevated Intra-Abdominal Pressure on the Contractile Activity and Reactivity of Smooth Muscle Tissue from Rat Gastrointestinal Tract to Galantamine and Drotaverine (No-SPA)

Deenichin

A²,

Mollov³

et al. 2010

Folia Medica

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Aim: the aim of the present study was to determine the nature and intensity of changes in the contractile activity and reactivity of gastrointestinal smooth muscle tissue in conditions of increased intra-abdominal pressure. methods: a method for recording isometric contractions of isolated smooth muscle preparations from gastric corpus, duodenum and sigmoid colon of rats was used. Results: two groups of rats were used in the study -control animals and animals with elevated abdominal pressure. it was established that pressure of 25 mmhg for 60 min did not cause statistically significant change in the tone and parameters of the spontaneous contractions in all preparation types, as well as in their reactivity to drotaverine (no-spa). Statistically significant increase in the strength of the tonic effects of galantamine (1.10 -6 -1.10 -3 mg/ml) was found in all types of smooth muscles preparations isolated from rats with increased abdominal pressure compared with preparations from the control rats. ConClusions: The statistically significant increase in the galantamine-induced effects on smooth muscle preparations is associated with increase in the contractile effectiveness of acetylcholine. m-type cholinergic receptors are predominantly involved in the processes, probably sensibilized from processes activated by the increased intra-abdominal pressure.

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“…15 Their activation stimulates release of neurotransmitters like glutamine, serotonin, dopamine, GAPA and/or VIP etc. with SM effects diverse in character.…”

Section: On the Frequency Of Phasic Contractionsmentioning

confidence: 99%

Effect of Elevated Intra-Abdominal Pressure on the Contractile Activity and Reactivity of Smooth Muscle Tissue from Rat Gastrointestinal Tract to Galantamine and Drotaverine (No-SPA)

Deenichin

A²,

Mollov³

et al. 2010

Folia Medica

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“…This led to the suggestion that acetylcholinesterase inhibitors (AChEI) would preserve a putative deficit in acetylcholine levels associated with AD, and thus might reserve the memory impairments (Schneider, 2001;Guardado-Santervas, 2001;Gauthier, 2001). Therefore, a number of AChEI have been developed as candidates for the symptomatic treatment of AD, including natural compounds, such as physostigmine, huperzine A and galanthamine as well as various synthetic compounds such as tacrine, donepezile and rivastigmine (Davis and Mohs, 1982;Liu et al, 1986;Summers et al, 1986;Mutafova-Yambolieva et al, 1993;Rogers et al, 1998;Potkin et al, 2001). Among these, galanthamine, an Amaryllidaceae alkaloid isolated from the bulbs of Galanthus species.…”

Section: Introductionmentioning

confidence: 99%

Sustainable Use of Various Amaryllidaceae Plants Against Alzheimer's Disease

Orhan¹,

Şener²

2005

Acta Hortic.

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Alzheimer's Disease (AD), a slowly progressive neuropsychiatric illness, principally characterized by memory deficits, has become the fourth leading cause of death in developed nations. Since the patients with AD suffer from marked reduction of cholinergic neuronal function resulting in a deficiency in acetylcholine (ACh) concentration in the brain, and these reductions are associated with impairments in memory, cholinergic enhancement strategies have been at the forefront of efforts to palliate pharmacologically the cognitive symptoms. Therefore, treatment approaches have been focused on the acetylcholinesterase inhibitors (AChEI) which are the most promising drugs demonstrating efficacy in the treatment of AD. Since, recently, galanthamine, an alkaloid isolated from different Galanthus species (Amaryllidaceae), has been found to be a potent and reversible acetylcholinesterase inhibitor, this development has prompted us to investigate the anticholinesterase activity in other plant species of Amaryllidaceae growing in Turkey, namely Galanthus elwesii, G. ikariae, Narcissus tazetta subsp. tazetta, Leucojum aestivum and Pancratium maritimum by Ellman method in comparison with galanthamine as the standard drug. Bioactivity-directed fractionation and isolation studies carried out on G. ikariae and N. tazetta subsp. tazetta extracts afforded 8 Amaryllidaceae-type alkaloids in total. We found that the activity of both of the plant extracts was due to the synergistic interaction of the alkaloids isolated. a Values were expressed as mean ± SEM p>0.05:-, p<0.05: + , p<0.01: ++ , p<0.001: +++

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Medical and toxicological aspects of chemical warfare: the nature, classification, and management of chemical agents used in warfare

Emmett

Byers

Blain

2022

Current Practice in Forensic Medicine

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Comparative effects of the anticholinesterase drug galanthamine on the mechanical activity of isolated rat jejunum and ileum

Cited by 8 publications

References 14 publications

Effect of Elevated Intra-Abdominal Pressure on the Contractile Activity and Reactivity of Smooth Muscle Tissue from Rat Gastrointestinal Tract to Galantamine and Drotaverine (No-SPA)

Effect of Elevated Intra-Abdominal Pressure on the Contractile Activity and Reactivity of Smooth Muscle Tissue from Rat Gastrointestinal Tract to Galantamine and Drotaverine (No-SPA)

Sustainable Use of Various Amaryllidaceae Plants Against Alzheimer's Disease

Medical and toxicological aspects of chemical warfare: the nature, classification, and management of chemical agents used in warfare

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