Comparative Effects of Therapy With Captopril and Digoxin in Patients With Mild to Moderate Heart Failure

Abstract

This multicenter, double-blind, placebo-controlled study compares the effects of captopril treatment with those of digoxin treatment during maintenance diuretic therapy in patients with mild to moderate heart failure. Compared with placebo, captopril therapy resulted in significantly improved exercise time (mean increase, 82 s vs 35 s) and improved New York Heart Association class (41% vs 22%), but digoxin therapy did not. Digoxin treatment increased ejection fraction (4.4% increase) compared with captopril therapy (1.8% increase) and placebo (0.9% increase). The number of ventricular premature beats decreased 45% in the captopril group and increased 4% in the digoxin group in patients with more than ten ventricular premature beats per hour. Treatment failures, increased

Extracting Features from Poincaré Plots to Distinguish Congestive Heart Failure Patients According to NYHA Classes

“…Indeed, augmenting the dataset would allow future researchers to test also other powerful algorithms which we had not the chance to use in this research due to the unbalanced dataset. On the other hand (i.e., from a clinical point of view), the considered dataset lacked enough NYHA class IV patients and overlooked the potential separation of NYHA class II patients in the subclasses NYHA IIS and IIM (where the indexes "S" and "M" indicate a slight or moderate limitation of physical activity, respectively) [62]. Clearly, further research using such accurate dataset would be desirable to understand further potentialities of the proposed methodology.…”

Relationship Between Procedural Right Bundle Branch Block and 1-Year Outcome After Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy ― A Retrospective Study ―

“…tional class of II were stratified into 2 groups based on physical activity limitations: those with slight (Class IIs) and those with moderate (Class IIm) limitations. 16 From the potential candidates, we carefully excluded patients with subaortic membranous stenosis, abnormal insertion of the papillary muscle or tendon, and large apical aneurysms. To identify the target septal perforator branch, coronary angiography and left ventriculography were performed simultaneously.…”

Study on Drug Utilization Evaluation in Geriatric Medical Inpatients in a Quaternary Care Hospital

“…Alpha blocker Prazosin High risk of orthostatic hypotension 12 Thiazide diuretics, ACEI, ARB, CCB [20] Centrally acting anti hypertensives Clonidine High risk of orthostatic hypotension, bradycardia,C NS effect 8 ACEI, ARB ,thiazide diuretics [19] Anti arrhythmic Amiodarone Associated with thyroid diseases,pulmo nary disorders and QT interval prolongation 4 Dronedarone [21] Sympathomimetic Digoxin Increased risk of toxicity and no additional benefit with high dose 2 Captopril [22] CCB Nifedipine Risk of precipitating myocardial ischmeia 2 Amlodipine [19] CNS Amitriptyline Sedative and orthostatic hypotension 9 For depression SSRI (except paroxetine), SNRI,bupropion, for neuropathic pain SNRI,gabapentin,pregabalin and lidocaine patch [19] Avoid.…”