Objective: Occupational therapy (OT) for cerebral palsy focuses on the development of skills necessary for the performance of activities of daily living. The aim of this systematic review was to determine whether OT interventions improve outcome for children with cerebral palsy (CP). Methods: An extensive search in MEDLINE, CINAHL, EMBASE, AMED and SCISEARCH was performed. Studies with controlled and uncontrolled designs were included. Six intervention categories were distinguished and individually analysed using a best-evidence synthesis. This synthesis is based on the type of design, the methodological quality, the type of outcome measures and the statistical signi cance of the ndings. Results: Seventeen studies were included in this review, seven of which were randomized controlled trials (RCTs). One RCT had a high methodological quality. The analyses resulted in insuf cient evidence of the ef cacy of occupational therapy in all intervention categories, due to the low methodological quality of studies presenting statistically nonsigni cant results. Conclusion: Despite the reasonable number of studies identi ed, the inconclusive ndings regarding the ef cacy of occupational therapy for children with cerebral palsy may be a re ection of the dif culties in ef cacy research in OT for children with CP. Future research should critically re ect on methodological issues.