Comparative effects of vitamin D and methylprednisolone against ischemia/reperfusion injury of rabbit spinal cords

Gürer, Bora; Karakoç, Abdullah; Bektaşoğlu, Pınar Kuru; Kertmen, Hayri; Kanat, Mehmet Ali; Arıkök, Ata Türker; Ergüder, Berrin İmge; Sargon, Mustafa F.; Öztürk, Özden Çağlar; Çelikoğlu, Erhan

doi:10.1016/j.ejphar.2017.07.028

Cited by 14 publications

(15 citation statements)

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“…Notably, the short-term administration of calcitriol immediately after SCI was also reported to attenuate the histological damage and neuron loss by reducing oxidative stress, inhibiting apoptosis, and promoting autophagy. In addition, pretreatment of calcitriol before SCI also exhibited a protective effect on the ischemia/reperfusion injury of the spinal cord, which was mediated by inhibiting neuronal apoptosis and suppressing regional and general oxidative stress ( 53 ). The immunomodulatory property of VitD raises the potential that it may alter the functional status of microglia/macrophages and astrocytes, the key players in the post-SCI neuroinflammation, to improve repairment.…”

Section: Discussionmentioning

confidence: 99%

Section: Neuroprotective Effect Of Vitamin D In Non-human Experimenta...mentioning

confidence: 99%

“…In the non-human experimental SCI, we retrieved five studies supporting the neuroprotective effect of VitD supplementation (51)(52)(53)(54)(55). The proposed mechanisms are multidimensional, involving promoting axonal survival (51,52), reducing neuronal loss by attenuating oxidative stress (53,55), suppressing neuroinflammation (54) and modulation of autophagy ((55), Table 5). Oral delivery of VitD for 4 months in a compression SCI model at T10 level improved respiratory adjustment to fatigue and normalized Hoffman reflex via increasing the number of axons crossing the lesion site (51).…”

Section: Neuroprotective Effect Of Vitamin D In Non-human Experimenta...mentioning

confidence: 99%

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Impact of vitamin D on the prognosis after spinal cord injury: A systematic review

Wang

Gan²,

Wu³

et al. 2023

Front. Nutr.

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Vitamin D (VitD) insufficiency is a worldwide health problem and affects billions of people. Spinal cord injury (SCI) patients seem more susceptible to developing suboptimal levels of VitD. However, the literature regarding its impact on the prognosis of SCI is limited. Thus, in this review, we systematically investigated the published studies via a combination of keywords associated with SCI and VitD in four medical databases (Medline, Embase, Scopus, and Web of Science). All included studies were analyzed, and selected clinical data on the prevalence of VitD insufficiency (serum 25-hydroxyvitamin D < 30 ng/ml) and deficiency (serum 25-hydroxyvitamin D < 20 ng/ml) were collected for further meta-analysis via random effects. Through literature review, a total of 35 studies were eligible and included. The meta-analysis of VitD status (13 studies, 1,962 patients) indicated high prevalence of insufficiency (81.6% [75.7, 87.5]) and deficiency (52.5% [38.1, 66.9]) after SCI. Besides, low levels of VitD were reported to be associated with a higher risk of skeletal diseases, venous thromboembolism, psychoneurological syndromes, and chest illness after injury. Existing literature suggested that supplemental therapy might act as an adjuvant treatment to facilitate post-injury rehabilitation. Non-human experimental studies highlighted the neuroprotective effect of VitD, which was associated with enhancing axonal and neuronal survival, suppressing neuroinflammation, and modulating autophagy. Therefore, the current evidence suggests that the prevalence of VitD insufficiency is high in the SCI population, and low-level VitD may impair functional restoration after SCI. VitD supplemental treatment may have potential benefits to accelerate rehabilitation in mechanistically related processes after SCI. However, due to the limitation of the available evidence, more well-designed randomized controlled trials and mechanism experimental research are still needed to validate its therapeutic effect, elucidate its neuroprotective mechanism, and develop novel treatments.

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Section: Discussionmentioning

confidence: 99%

Section: Neuroprotective Effect Of Vitamin D In Non-human Experimenta...mentioning

confidence: 99%

Section: Neuroprotective Effect Of Vitamin D In Non-human Experimenta...mentioning

confidence: 99%

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Impact of vitamin D on the prognosis after spinal cord injury: A systematic review

Wang

Gan²,

Wu³

et al. 2023

Front. Nutr.

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“…Previous studies have reported that the therapeutic effects of VitD treatment in neuronal injury [28] were mediated by various mechanisms, including immunomodulation, oxidative stress, and autophagy [14,29]. Pretreatment with calcitriol has also been shown to protect spinal cords from ischemia or reperfusion injury in rabbits [30]. The role of VitD in promoting myelination has been well documented in peripheral nerve injury and multiple sclerosis models [31][32][33][34], but is less well defined in spinal cord injury.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Promotes Remyelination by Suppressing c-Myc and Inducing Oligodendrocyte Precursor Cell Differentiation after Traumatic Spinal Cord Injury

Li¹,

Yao²,

Liu³

et al. 2022

Int. J. Biol. Sci.

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Demyelination due to oligodendrocytes loss occurs after traumatic spinal cord injury (TSCI). Several studies have suggested the therapeutic potential of vitamin D (VitD) in demyelinating diseases. However, experimental evidence in the context of TSCI is limited, particularly in the presence of prior VitD-deficiency. In the present study, a contusion and a transection TSCI rat model were used, representing mild and severe injury, respectively. Motor recovery was assessed in rats with normal VitD level or with VitD-deficiency after 8 weeks' treatment post-TSCI (Cholecalciferol, 500 IU/kg/day). The impact on myelin integrity was examined by transmission electron microscopy and studied in vitro using primary culture of oligodendrocytes. We found that VitD treatment post-TSCI effectively improved hindlimb movement in rats with normal VitD level irrespective of injury severity. However, cord-transected rats with prior deficiency did not seem to benefit from VitD supplementation. Our data further suggested that having sufficient VitD was essential for persevering myelin integrity after injury. VitD rescued oligodendrocytes from apoptotic cell death in vitro and enhanced their myelinating ability towards dorsal root axons. Enhanced myelination was mediated by increased oligodendrocyte precursor cells (OPCs) differentiation into oligodendrocytes in concert with c-Myc downregulation and suppressed OPCs proliferation. Our study provides novel insights into the functioning of VitD as a regulator of OPCs differentiation as well as strong preclinical evidence supporting future clinical testing of VitD for TSCI.

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“…lowered malondialdehyde (MDA) levels, reduced myeloperoxidase, xanthine oxidase and caspase-3 activities, but increased catalase levels. The animals pretreated with calcitriol showed better histopathological, ultrastructural, and neurological scores [ 107 ]. The importance of adequate vitamin D supplementation in ameliorating the brain injury caused by I/R has been underlined by the authors of a study on Mongolian gerbils [ 108 ].…”

Section: The Effects Of Calcitriol On Ischemia-related Neuronal Injur...mentioning

confidence: 99%

Vitamin D3 and Ischemic Stroke: A Narrative Review

et al. 2022

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Ischemic stroke is one of the major causes of death and permanent disability worldwide. The only efficient treatment to date is anticoagulant therapy and thrombectomy, which enable restitution of blood flow to ischemic tissues. Numerous promising neuroprotectants have failed in clinical trials. Given the complex pathomechanism of stroke, a multitarget pharmacotherapy seems a more rational approach in stroke prevention and treatment than drugs acting on single molecular targets. Recently, vitamin D3 has emerged as a potential treatment adjunct for ischemic stroke, as it interferes with the key prosurvival pathways and shows neuroprotective, anti-inflammatory, regenerative and anti-aging properties in both neuronal and vascular tissue. Moreover, the stimulatory effect of vitamin D3 on brain-derived neurotrophic factor (BDNF) signaling and neuroplasticity may play a role not only in the recovery of neurological functions, but also in ameliorating post-stroke depression and anxiety. This narrative review presents advances in research on the biochemical mechanisms of stroke-related brain damage, and the genomic and non-genomic effects of vitamin D3 which may interfere with diverse cell death signaling pathways. Next, we discuss the results of in vitro and in vivo experimental studies on the neuroprotective potential of 1alpha,25-dihydroxyvitamin D3 (calcitriol) in brain ischemia models. Finally, the outcomes of clinical trials on vitamin D3 efficiency in ischemic stroke patients are briefly reviewed. Despite the mixed results of the clinical trials, it appears that vitamin D3 still holds promise in preventing or ameliorating neurological and psychiatric consequences of ischemic stroke and certainly deserves further study.

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Comparative effects of vitamin D and methylprednisolone against ischemia/reperfusion injury of rabbit spinal cords

Cited by 14 publications

References 83 publications

Impact of vitamin D on the prognosis after spinal cord injury: A systematic review

Impact of vitamin D on the prognosis after spinal cord injury: A systematic review

Vitamin D Promotes Remyelination by Suppressing c-Myc and Inducing Oligodendrocyte Precursor Cell Differentiation after Traumatic Spinal Cord Injury

Vitamin D3 and Ischemic Stroke: A Narrative Review

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