Comparative efficacies of topical antiseptic eardrops against biofilms from methicillin-resistant Staphylococcus aureus and quinolone-resistant Pseudomonas aeruginosa

Ck, Youn; Yao, Jun; Er, Jo; Sj, Jang; Song, He Sun; Si, Cho

doi:10.1017/s0022215118000932

Cited by 11 publications

(6 citation statements)

References 17 publications

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“…The effects of BA on the number of viable microorganisms in biofilm were tested by the colony counting method. A previous study evaluated the anti-biofilm activity of BA on MRSA and P. aeruginosa resistant to quinolone, and it was stated that 4% BA suspension was a strong biofilm inhibitor (24). In the current study, it was found that BA reduced the number of viable microorganisms in biofilm significantly even for MRSA, P. aeruginosa and C. albicans.…”

Section: Discussionsupporting

confidence: 49%

In vitro Activity of Boric Acid against Biofilm Formation and Biofilm Viability in Medically Important Microorganisms

İnce¹

2022

Erciyes Med J

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Section: Discussionsupporting

confidence: 49%

In vitro Activity of Boric Acid against Biofilm Formation and Biofilm Viability in Medically Important Microorganisms

İnce¹

2022

Erciyes Med J

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“…A single-animal study suggested ototoxicity for acetic acid solutions with pH<5.0 (5% acetic acid has pH 2.4) (40), although the ototoxicity of acetic acid has not been systematically studied. Four percent boric acid solution has been found to inhibit PA biofilm formation (41), while reports of activity against SA biofilms are mixed (42,43); the efficacy of boric acid powder against biofilms has not been assessed. Boric acid 4% solution may be ototoxic in alcohol but not distilled water solutions (44), while there is no evidence of ototoxicity for boric acid powder in animal studies (45).…”

Section: Biofilm Dispersal Is Not the Answermentioning

confidence: 99%

Topical Therapy Failure in Chronic Suppurative Otitis Media is Due to Persister Cells in Biofilms

Maria

Kaufman

Bacacao

et al. 2021

Otology &Amp; Neurotology

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Objective: Chronic suppurative otitis media (CSOM) is characterized by a chronically draining middle ear. CSOM is typically treated with multiple courses of antibiotics or antiseptics which are successful in achieving quiescence; however, the disease is prone to relapse. Understanding why these treatment failures occur is essential. Study Design: The minimum inhibitory concentration (MIC), minimal biofilm eradication concentration, and the inhibitory zone were determined for ototopicals and ofloxacin for the laboratory strains and CSOM-derived isolates. The percentage of persister cells and bacterial biofilm formation were measured. Disease eradication was tested in a validated invivo model of CSOM after treatment with ofloxacin. Setting: Microbiology Laboratory. Methods: Basic science experiments were performed to measure the effectiveness of a number of compounds against CSOM bacteria in a number of distinct settings. Results: The minimal biofilm eradication concentration is higher than is physiologically achievable with commercial preparations, except for povo-iodine. Clincial isolates of CSOM have equivalent biofilm-forming ability but increased proportions of persister cells. Ofloxacin can convert to inactive disease temporarily but fails to eradicate disease in an in-vivo model. Conclusions: Higher percentages of persister cells in clinical CSOM isolates are associated with resistance to ototopicals. Current ototopicals, except povo-iodine, have limited clinical effectiveness; however, it is unknown what the maximum achievable concentration is and there are ototoxicity concerns. Fluoroquinolones, while successful in producing inactive disease in the short term, have the potential to encourage antimicrobial resistance and disease recalcitrance and do not achieve a permanent remission. Given these limitations, clinicians should consider surgery earlier or use of clinically safe concentrations of povo-iodine earlier into the treatment algorithm.

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“…A new insight revitalizes the findings of Hippocrates that suggest vinegar is an effective treatment of burns to avoid infection. Acetic acid is capable of treating particularly pseudomonal wound infections and can break down biofilms [16,17]. Hippocrates was also known to use red wine with similar effects to treat burn wounds [9] (p. 367 et sqq.).…”

Section: Plant-based Productsmentioning

confidence: 99%

Burn Care in the Greek and Roman Antiquity

et al. 2020

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The last century brought about more rapid new developments in the treatment of burns, which significantly lowered the mortality of burn injuries. However, burns were already treated in antiquity, where the threshold from spirituality to scientific medicine originated. The existing literature on burn treatment is very limited and there are many cross-references, some of them incorrect. The aim of this work by an interdisciplinary team of historians and physicians is to offer a more precise reproduction of the burn treatment of Greek and Roman antiquity using original texts in context and with a modern scientific background. There are many sources from ancient doctors on the subject of burn treatment, as well as the treatment of burned-out wounds and frostbite, which have not yet been mentioned. The literature research also showed an understanding of scientific contexts in ancient medicine, such as antiseptics or rheology. Interestingly, there was a change in burn medicine from everyday Greek medicine to Roman military medicine with other burn patterns. The care of patients using analgetics and the therapy of burn shock arose from the literature. The ancient world is considered to be the foundation of medicine, but it is believed to have been based mainly on shamanism rather than science. However, already more than two millennia ago, burns were correctly assessed and treated according to today’s scientific standards and scientific relationships were recognized.

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Comparative efficacies of topical antiseptic eardrops against biofilms from methicillin-resistant Staphylococcus aureus and quinolone-resistant Pseudomonas aeruginosa

Abstract: The results indicate that 4 per cent boric acid solution and vinegar with water (1:1) are potent inhibitors of biofilms from methicillin-resistant S aureus and quinolone-resistant P aeruginosa, and provide safe pH levels for avoiding ototoxicity.

Cited by 11 publications

References 17 publications

In vitro Activity of Boric Acid against Biofilm Formation and Biofilm Viability in Medically Important Microorganisms

In vitro Activity of Boric Acid against Biofilm Formation and Biofilm Viability in Medically Important Microorganisms

Topical Therapy Failure in Chronic Suppurative Otitis Media is Due to Persister Cells in Biofilms

Burn Care in the Greek and Roman Antiquity

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