Comparative efficacy and bioavailability of different praziquantel brands

Effect of Ketoconazole, a Cytochrome P450 Inhibitor, on the Efficacy of Quinine and Halofantrine against Schistosoma mansoni in Mice

“…In the current work, infection of mice with S. mansoni produced a significant decrease in the hepatic activities of CYP450 and CYT b5 (65.3% and 62.1%, respectively). These findings are in agreement with previous investigations [39-41] and are attributed to denaturation of the CYP450 to its inactive form CYP422 as a result of different pathological reactions that follow egg deposition in the liver, including granulomatous, immunologic, and fibrogenic reactions [42]. Moreover, administration of KTZ in the present investigation before QN or HF enhanced the inhibition in the activities of CYP450 (85.7% and 83.8% vs 45.4% and 52.8%) and CYT b5 (75.5% and 73.5% vs 46.0% and 53.7%, respectively) than observed in mice treated with QN or HF alone.…”

Efficacy and mechanism of action of arachidonic acid in the treatment of hamsters infected with Schistosoma mansoni or Schistosoma haematobium

“…Entire elimination of the worms was not achieved in any experiment. Elimination of 100% of schistosomes in treated hamsters or mice was also not obtained with artemether [6,7], mefloquine [26] or PZQ [27], pointing to the need for repeated treatments and development of a sterilising vaccine.…”

Effectiveness of a Pre-treatment Snack on the Uptake of Mass Treatment for Schistosomiasis in Uganda: A Cluster Randomized Trial

“…Praziquantel is the current drug of choice for schistosomiasis control and is virtually the only anti-schistosomal drug readily available for treatment [28],[44],[45]. The drug is given orally, is effective as a single dose for the three major species of schistosomes, has a low toxicological profile, is well tolerated, and confers some resistance to re-infection [46].…”