Comparative Efficacy and Safety Evaluation of Tramadol plus Diclofenac versus Tramadol plus Paracetamol in a Subgroup of Indian Patients with Moderate to Severe Acute Musculoskeletal Pain: A Phase III, 5 Day Open Label Study

Tramadol/Diclofenac Fixed-Dose Combination: A Review of Its Use in Severe Acute Pain

“…Joint pain, traumatic pain, and musculoskeletal conditions are highly prevalent and the most common cause of severe acute pain and physical disability. These two studies support the use of a tramadol/diclofenac FDC, which targets multiple pain pathways and pain transmitter substances, in the management of patients with acute severe inflammatory and traumatic pain [68,72].…”

“…2c). Overall, the findings from this phase III trial demonstrated that tramadol/ diclofenac FDC relieves acute pain in AMSP, AFOA, AFRA, and POP patients more effectively than tramadol/paracetamol FDC [68,72].…”

“…These results substantiated the findings of the phase III trial. In both studies, on tramadol/diclofenac FDC tablet was administered twice daily, whereas tramadol/paracetamol FDC was prescribed at a dosage of two tablets every 4-6 h, up to a maximum of eight tablets daily [68,72]. Tramadol/diclofenac FDC offered effective treatment at low doses of individual drugs and reduced the overall pill burden.…”