Comparative efficacy and safety of intrathecal ropivacaine versus intrathecal bupivacaine in patients undergoing lower abdominal surgical procedures

Adhikari, Prasenjit; Vyas, Varsha; Naseem, Shahbaz; Shelke, Ulpesh

doi:10.4103/ijpn.ijpn_54_18

Cited by 3 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Surekha et al, 13 studied equivoque (2.2 mL) isobaric Ropivacaine 0.75% against isobaric bupivacaine 0.5% in spinal anesthesia for lower abdominal and lower limb surgeries and found that ropivacaine provided comparable quality of sensory block, but the slower onset and significantly shorter duration of motor block and better hemodynamic stability compared to Bupivacaine. Adhikari et al, 14 studied intrathecal equivoque (3 mL) 0.75% isobaric ropivacaine against 0.5% isobaric bupivacaine for lower abdominal surgeries and found comparable sensory block characteristics in both groups with significantly early motor recovery and lower incidence of hypotension and bradycardia in ropivacaine group. Olapour et al, 15 studied 15 mg 1% ropivacaine against 10 mg 0.5% Bupivacaine in caesarian delivery under spinal anesthesia and found that onset time of sensory and motor blockade of Ropivacaine was significantly longer than that of Bupivacaine with short duration of sensory and motor block.…”

Section: Discussionmentioning

confidence: 99%

To compare the efficacy of intrathecal 0.75% heavy ropivacaine and 0.5% heavy bupivacaine for lower abdominal and lower limb surgery

Harshad Mangaldas Mahajan,

Sandipbhai Jivanbhai Patel

2023

Asian J Med Sci

View full text Add to dashboard Cite

Background: Spinal anesthesia is the most popular regional anesthesia technique for lower limb and lower abdominal surgery. Bupivacaine 0.5% heavy is commonly used for intrathecal use. New long-acting local anesthetic agents such as ropivacaine have claimed benefits of reduced cardiac toxicity on overdose and more specific effects on sensory rather than motor nerve fibers. The use of intrathecal hyperbaric ropivacaine is not much studied. With this background, we studied intrathecal ropivacaine hyperbaric 0.75% against intrathecal bupivacaine hyperbaric 0.5% for lower abdominal and lower limb surgery. Aims and Objectives: To note the effectiveness of intrathecal ropivacaine and bupivacaine on characteristics of subarachnoid block such as sensory block, motor block, hemodynamic parameters, and complications if any. Materials and Methods: We randomized patients undergoing lower abdominal surgeries and lower limb orthopedic surgeries under spinal anesthesia into two groups so as to receive intrathecal either ropivacaine 0.75% hyperbaric (3 mL) or bupivacaine 0.5% hyperbaric (3mL) and noted study parameters. Results: Time of sensory block onset (P=0.0005), peak sensory level (P=0.0029), and onset of L1 bromage-3 motor block (P=1.27E–08) was significantly delayed in the ropivacaine group as compared to bupivacaine group. However, maximum sensory level achieved (T6), time required for two-segment sensory regressions (P=0.1162), and time of onset of pain (P=0.1162) were comparable in both groups. Conclusion: Intrathecal ropivacaine 0.75% hyperbaric produced slow onset sensory and motor block than 0.5% hyperbaric bupivacaine with comparable cephalic spread and duration of sensory block.

show abstract

Section: Discussionmentioning

confidence: 99%

To compare the efficacy of intrathecal 0.75% heavy ropivacaine and 0.5% heavy bupivacaine for lower abdominal and lower limb surgery

Harshad Mangaldas Mahajan,

Sandipbhai Jivanbhai Patel

2023

Asian J Med Sci

View full text Add to dashboard Cite

show abstract

Thoracic segmental spinal anaesthesia a boon in challenging case scenarios: A case series

Nath,

Deshpande,

Kulkarni

et al. 2024

IJCA

View full text Add to dashboard Cite

Thoracic segmental spinal anaesthesia is a regional anaesthesia technique that can strategically serve as an alternative asset to general anaesthesia for certain high-risk cases. The procedure is picking up pace as it is beneficial in maintaining hemodynamic stability for these patients and reducing side effects encountered with general anaesthesia. Segmental Thoracic Spinal anaesthesia is a realistic, reliable, and reasonable anaesthesia technique that can be implemented for abdominal and thoracic surgeries. Additionally, it has fewer postoperative complications and superior patient satisfaction. We would like to discuss 5 case scenarios where TSA were used mode of anaesthesia as they were found to be high risk for GA.

show abstract

Intrathecal ropivacaine versus bupivacaine in a non-obstetric population- A meta-analysis and trial sequential analysis

Khalil,

Mehmud,

Banerjee

et al. 2024

Indian Journal of Anaesthesia

View full text Add to dashboard Cite

Background and Aims: Intrathecal bupivacaine is used for anaesthesia and analgesia but is associated with hypotension. Ropivacaine is an alternative drug that may have fewer cardiotoxic and neurotoxic events. This meta-analysis investigated whether intrathecal ropivacaine is associated with reduced hypotension as compared to bupivacaine. Methods: The meta-analysis is registered in the International Prospective Register of Systematic Reviews (PROSPERO). The databases PubMed, Cinahl Plus, Google Scholar, and Scopus were searched, and papers from January 1980 to January 2023 were deemed eligible and filtered using predetermined inclusion and exclusion criteria. The primary outcome was the incidence of hypotension. Secondary outcomes were the duration of sensory block, duration of motor block, incidence of bradycardia, ephedrine usage, and duration of analgesia. Jadad scores were used to evaluate the quality of the papers. RevMan statistical software® utilised inverse variance and a random effect model to calculate the standardised mean difference with 95% confidence intervals for continuous variables and the Mantel–Haenszel test and the random effect model to calculate the odds ratio for dichotomous variables. Results: Thirty-three papers, including 2475 patients in total, were included. The Jadad score was between 1 and 5. The incidence of hypotension was significantly higher with intrathecal bupivacaine than with ropivacaine (P = 0.02). The duration of sensory block (P < 0.001) and motor block (P < 0.001) was prolonged with intrathecal bupivacaine. The duration of analgesia favoured intrathecal bupivacaine (P = 0.003). Conclusion: Intrathecal ropivacaine has a reduced incidence of hypotension and a reduced duration of sensory block compared to bupivacaine.

show abstract

Comparative efficacy and safety of intrathecal ropivacaine versus intrathecal bupivacaine in patients undergoing lower abdominal surgical procedures

Cited by 3 publications

References 13 publications

To compare the efficacy of intrathecal 0.75% heavy ropivacaine and 0.5% heavy bupivacaine for lower abdominal and lower limb surgery

To compare the efficacy of intrathecal 0.75% heavy ropivacaine and 0.5% heavy bupivacaine for lower abdominal and lower limb surgery

Thoracic segmental spinal anaesthesia a boon in challenging case scenarios: A case series

Intrathecal ropivacaine versus bupivacaine in a non-obstetric population- A meta-analysis and trial sequential analysis

Contact Info

Product

Resources

About