Comparative efficacy and safety of traditional Chinese patent medicine for the treatment of type 2 diabetes mellitus

Li, Jie; Zhao, Sen; Huang, Yanqin; Li, Chuancheng; Li, Bing; Xu, Yunsheng

doi:10.1097/md.0000000000022564

Cited by 2 publications

(5 citation statements)

References 25 publications

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“…Two of the included RCTs (Wu WZ., 2019;Li P., 2017) involving 82 participants reported the effects of Baduanjin exercise on FINS. Using a model with fixed effects, the experimental group was able to decrease FINS substantially more than the control group (MD:-2.63, 95% CI:-3.81 to -1.45, P<0.0001, I 2 = 0%).…”

Section: Risk Of Bias Assessmentmentioning

confidence: 99%

“…The results of the sensitivity analysis indicate that this result was robust (Supplementary Material 4.14). Zhang XH, Xie PF, et al, 2019;Qi L., 2021;Li FX., 2020;Zhu RL, Miu XQ & Li SJ., 2020;He K, Liu L, Bian RR, et al, 2019;Wu WZ., 2019;Yang H., 2018;Li Y., 2017;Li P., 2017;Zhuang Q, Shen B & Wang J., 2017;Hou JY., 2016;Wang CY & Zhang HY., 2015;Yang MC., 2012;Huang RC & Deng XD., 2011;Zhou LB, Zhang JQ, Zhao XL, et al, 2011;Li XH., 2009;Pan HS & Feng YC., 2008;Wang YG, Liu LJ, Kou ZJ, et al, 2007;Liu T, Bai S & Zhang R C., 2018) including 1307 participants mentioned TC.…”

Section: Risk Of Bias Assessmentmentioning

confidence: 99%

“…Subgroup analyses revealed interactions that were unrelated to treatment duration (6 months; 6 months), intervention measures (Baduanjin alone; Combination of Baduanjin and other exercises), and intensity of intervention (Total exercise time per week 300min; Total exercise time per week 300min) (P=0.39, P=0.38, P=0.59, respectively) (Supplementary Material 4.16-4.18). The outcomes of Baduanjin exercise in TCM were reported in connection to the TG in twenty of the RCTs (Huang L & Ma Q., 2021;Yi WM, Zhang XH, Xie PF, et al, 2019;Qi L., 2021;Li FX., 2020;Zhu RL, Miu XQ & Li SJ., 2020;He K, Liu L, Bian RR, et al, 2019;Wu WZ., 2019;Yang H., 2018;Li Y., 2017;Li P., 2017;Zhuang Q, Shen B & Wang J., 2017;Hou JY., 2016;Wang CY & Zhang HY., 2015;Guan YX, Wang SS & Ma MN., 2012;Yang MC., 2012;Huang RC & Deng XD., 2011;Zhou LB, Zhang JQ, Zhao XL, et al, 2011;Li XH., 2009;Wang YG, Liu LJ, Kou ZJ, et al, 2007;Liu T, Bai S & Zhang R C., 2018) about 1338 participants that were included. In the comparison between the experimental group and the control group, the results obtained using the randomized-effect model demonstrated that the experimental group was able to achieve a lower TG (MD: -0.56, 95% CI: -0.82 to -0.30, P<0.00001, I 2 = 96%) (Figure 10).…”

Section: Risk Of Bias Assessmentmentioning

confidence: 99%

“…(Supplementary Material 4.24-4.26). The meta-analysis included nineteen studies (Huang L & Ma Q., 2021;Yi WM, Zhang XH, Xie PF, et al, 2019;Qi L., 2021;Li FX., 2020;He K, Liu L, Bian RR, et al, 2019;Wu WZ., 2019;Yang H., 2018;Li Y., 2017;Li P., 2017;Zhuang Q, Shen B & Wang J., 2017;Hou JY., 2016;Wang CY & Zhang HY., 2015;Yang MC., 2012;Huang RC & Deng XD., 2011;Zhou LB, Zhang JQ, Zhao XL, et al, 2011;Li XH., 2009;Liu T, Bai S & Zhang R C., 2018) about 1207 participants that reported on the presence of HDL-C. The meta-analysis results, which were assessed using a randomized-effects model, indicated that the HDL-C of Baduanjin exercise in TCM increased compared to that of the control group (MD: 0.11, 95% CI: 0.06 to 0.16, P<0.0001, I 2 =82%) (Figure 12).…”

Section: Risk Of Bias Assessmentmentioning

confidence: 99%

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Effects of Baduanjin Exercise on Glucose and Lipid Metabolism in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Guo

Cai

Wang

et al. 2023

CRMS

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Background: Type 2 diabetes mellitus (T2DM) refers to a metabolic disorder characterized by persistent hyperglycemia. Uncontrolled blood glucose levels over time may lead to serious complications, possibly even death. As an adjunctive treatment for T2DM, increasing numbers of clinical studies have demonstrated that Baduanjin (the Eight Section Brocades)—one of Traditional Asian exercise may effectively control fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), and 2h postprandial plasma glucose (P2hPG) as well as blood lipid levels of diabetic patients. However, the primary evidence demonstrating the clinical benefit of Baduanjin exercise in diabetic patients remains insufficient, especially the intervention effect on glucose and lipid metabolism is not fully understood. Objectives: The purpose of this study is to examine the effects of Baduanjin exercise on glucose and lipid metabolism in individuals with type 2 diabetes in randomized controlled trials (RCTs). Methods: Nine electronic databases were searched from the database’s inception until January 31th, 2023, without regard to language constraints (PubMed, Web of Science, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), Scopus, China National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform (WAN FANG), VIP information resource integration service platform (CQVIP) and China Biology Medicine (CBM)). Furthermore, information concerning unpublished or continuing clinical trials was searched within the National Institutes of Health clinical registry Clinical Trials, the International Clinical Trials Registry Platform, and the Chinese Clinical Trials Registry. RCTs that examined the effect of Baduanjin exercise on glucose and lipid metabolism were identified. The primary outcomes of this study were fasting plasma glucose (FPG), 2h postprandial plasma glucose (P2hPG) and glycosylated hemoglobin (HbA1c). The literature was chosen based on inclusion and exclusion criteria, with the Baduanjin exercise serving as the primary method for the experimental group. Selection, data collection and extraction of studies were conducted separately by at least two reviewers, with disagreements resolved through discussion. The mean difference (MD) with a 95% confidence interval (CI) was employed for continuous outcomes. Analysis of data and subgroups, as well as sensitivity analysis, were performed utilizing Review Manager V.5.4.1 (RevMan V.5.4.1) and Stata/MP 17.0. Results: This meta-analysis comprised twenty-six original studies with 1,779 individuals. Glucose metabolism: As a result of the pooled analysis, it demonstrated that combination treatment resulted in a reduction in the HbA1c (MD: -0.73, 95% CI: -0.91 to -0.55, P<0.00001), FPG (MD −1.14, 95% CI −1.38 to −0.90, P<0.00001), P2hPG (MD: -1.22, 95% CI: -1.66 to -0.78, P<0.00001), Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) (MD: -0.59, 95% CI: -1.07 to -0.11, P＝0.02), and Fasting Insulin (FINS) (MD: -2.63, 95% CI: -3.81 to -1.45, P<0.0001). Lipid metabolism: The results revealed that Baduanjin exercise could help T2DM patients improving the level of lipid metabolism, which reduced the level of Total cholesterol (TC) (MD: -0.36, 95% CI: -0.52 to -0.21, P<0.00001), Triglycerides (TG) (MD: -0.56, 95% CI: -0.82 to -0.30, P<0.0001), Low density lipoprotein (LDL-C) (MD: -0.19, 95% CI: -0.29 to -0.10, P＝0.0001) and increased the level of High-density lipoprotein (HDL-C) (MD: 0.11, 95% CI: 0.06 to 0.16, P<0.0001). Simultaneously, the combined findings also demonstrated that the interventions were efficacious in decreasing Body Mass Index (BMI) (MD: -1.14, 95% CI: -1.90 to -0.37, P＝0.004) and Waist-Hip Ratio (WHR) (MD: -0.07, 95% CI: -0.13 to -0.01, P＝0.02). Sensitivity analyses indicated that these results were robust. Conclusions: Current low-quality evidence demonstrated that T2DM patients through Baduanjin exercise could significantly improve the level of glucose and lipid metabolism. The evidence available was insufficient to establish the effects of Baduanjin exercise on T2DM patients. Further high-quality studies are needed to explore its effects of Baduanjin exercise on T2DM patients. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/display_record.php?Record ID=325538.

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Section: Risk Of Bias Assessmentmentioning

confidence: 99%

Section: Risk Of Bias Assessmentmentioning

confidence: 99%

Section: Risk Of Bias Assessmentmentioning

confidence: 99%

Section: Risk Of Bias Assessmentmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Baduanjin Exercise on Glucose and Lipid Metabolism in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Guo

Cai

Wang

et al. 2023

CRMS

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“…In recent years, traditional Chinese patent medicine (TCPM) has been widely used for treating T2DM, TCPMs contain various active constituents, which possess multiple therapeutic effects, including improvement of insulin sensitivity and regulation of glucose and lipid metabolism, improvement of diabetic complications, etc. (6). TCPMs that have been reported to combine with anti-hyperglycemic drugs to treat T2DM include Jinlida granules, Yuquan pill, and Tianqi capsules, etc.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of traditional Chinese patent medicine in collaboration with anti-hyperglycemic drugs on type 2 diabetes: study protocol for a multicenter, prospective cohort study

Pang¹,

Feng²,

Su³

et al. 2023

Ann Palliat Med

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Background: Traditional Chinese patent medicine (TCPM) has potential in the treatment of type 2 diabetes mellitus (T2DM). Some studies have reported TCPMs could effectively reduce blood glucose levels in diabetic patients. To enhance glycemic control, relieve uncomfortable symptoms and delay diabetic complications, integrative TCPM and anti-hyperglycemic drugs is essential. Here, we investigated the efficacy and safety of using TCPM according to syndrome differentiation in co-collaboration with antihyperglycemic drugs.Methods: Participants that met the diagnostic criteria of T2DM and traditional Chinese medicine (TCM) syndrome differentiation were included. This is a two-arm multicenter, prospective cohort study.Two hundred and six participants will be included, the cohorts were divided according to the treatment methods they choose. Both groups will propose a healthy lifestyle, the exposure group used TCPMs based on syndrome differentiation, while the control group do not use other therapies. Basic therapy of antihyperglycemic, lipid-lowering and anti-hypertensive treatment accompanied with both groups. The study duration will be 24 weeks, and being followed up for 2 years afterward. Telephone follow-up will be done every two weeks and participant follow-up will be done every four weeks during the intervention period.The primary outcome will be the changes in glycosylated hemoglobin, the secondary outcomes include the changes of blood glucose, blood pressure, blood lipids, body weight, body mass index, waist circumference, hip circumference, incidence of diabetic microvascular and macrovascular complications and improvement in TCM symptoms. T test, Wilcoxon rank sum test, chi-squared test, or Fisher exact test were regarded as the main statistical methods for comparing the outcome variables. Statistical tests will be two-sided, and significance will be assigned at P<0.05.Discussion: The design of the trial coincides with the real-world practice of TCM. We assume that participants with T2DM will be helped by TCPMs. If succeeded, this study will furnish evidence that TCPM in collaboration with anti-hyperglycemic drugs could improve glycolipid metabolism, relieve subjective symptoms and delay the incidence of diabetic complications.

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Comparative efficacy and safety of traditional Chinese patent medicine for the treatment of type 2 diabetes mellitus

Cited by 2 publications

References 25 publications

Effects of Baduanjin Exercise on Glucose and Lipid Metabolism in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Effects of Baduanjin Exercise on Glucose and Lipid Metabolism in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Efficacy and safety of traditional Chinese patent medicine in collaboration with anti-hyperglycemic drugs on type 2 diabetes: study protocol for a multicenter, prospective cohort study

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