2009
DOI: 10.1128/aac.00341-09
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Comparative Efficacy and Safety of Vancomycin versus Teicoplanin: Systematic Review and Meta-Analysis

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Cited by 250 publications
(188 citation statements)
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“…1 -3 Teicoplanin is a glycopeptide antibiotic with activity against methicillin-resistant staphylococci (MRSA and CoNS) and has several potential advantages over vancomycin, including better tolerability, lower risk of nephrotoxicity and improved ease of administration. 4,5 In older children, there is considerable pharmacokinetic (PK) variability in comparison with adults, with a much wider drug exposure (AUC) distribution among children. 6 Little is known about the pharmacokinetics (PK) of teicoplanin in neonates.…”
Section: Introductionmentioning
confidence: 99%
“…1 -3 Teicoplanin is a glycopeptide antibiotic with activity against methicillin-resistant staphylococci (MRSA and CoNS) and has several potential advantages over vancomycin, including better tolerability, lower risk of nephrotoxicity and improved ease of administration. 4,5 In older children, there is considerable pharmacokinetic (PK) variability in comparison with adults, with a much wider drug exposure (AUC) distribution among children. 6 Little is known about the pharmacokinetics (PK) of teicoplanin in neonates.…”
Section: Introductionmentioning
confidence: 99%
“…Several meta-analyses comparing vancomycin with linezolid and teicoplanin have also been published, [17][18][19] but since then, additional data have become available. We sought to summarize and study systematically the effectiveness and safety of vancomycin compared with other approved or investigational antibiotics using a meta-analytic method.…”
mentioning
confidence: 99%
“…Teicoplanin is a naturally occurring lipoglycopeptide that kills Gram-positive cocci by inhibiting peptidoglycan biosynthesis by binding to the D-alanyl-D-alanine termini of peptidoglycan intermediates, thus disrupting late-stage steps in cell wall biosynthesis [6]. This drug shows a great therapeutic effect to MRSA.…”
Section: Introductionmentioning
confidence: 99%