Comparative efficacy and safety of uricosuric agents in the treatment of gout or hyperuricemia: a systematic review and network meta-analysis

Li, Ya-Jia; Chen, Lirong; Yang, Zhong-Lei; Wang, Ping; Jiang, Fangfang; Guo, Yu; Qian, Kai; Yang, Mei; Yin, Sun‐Jun; He, Gong-Hao

doi:10.1007/s10067-022-06356-z

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Cited by 3 publications

References 40 publications

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Emerging Urate-Lowering Drugs and Pharmacologic Treatment Strategies for Gout: A Narrative Review

Terkeltaub

2023

Drugs

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Emerging Urate-Lowering Drugs and Pharmacologic Treatment Strategies for Gout: A Narrative Review

Terkeltaub

2023

Drugs

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Peptide NCTX15 derived from spider toxin gland effectively relieves hyperuricemia in mice

Liu,

Bian

et al. 2023

Biochemical and Biophysical Research Communications

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Multi-Omics analysis to identify the metabolic mechanism of the ethanol extract of Gymnadenia Conopsea R.Br. in hyperuricemia treatment

CHEN,

LIU,

NIE

et al. 2024

Preprint

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Background: The ethanol extract of Gymnadenia Conopsea R.Br. (Gym) has been shown to significantly lower uric acid levels. However, its uric acid reducing mechanism has not been studied from a multi-omics perspective. Objective: By conducting multiple omics studies and analyzing the metabolic characteristics of the ethanol extract of Gym on zebrafish with hyperuricemia (HUA), we aimed to provide insights into its metabolic mechanism during HUA treatment. Methods: Non-targeted metabolomics studies were conducted using ultra-high performance liquid chromatography-Q-Exactive mass spectrometry (UHPLC-QE MS). Samples were sequenced using second-generation sequencing technology on the Illumina sequencing platform, to perform paired-end sequencing of the gene library. Results: Different concentrations and doses of ethanol extracts of Gym significantly reversed the levels of 33 common biomarkers, including sphingosine, plant sphingosine, unsaturated fatty acids, and amino acids. These biomarkers were mainly involved in phenylalanine, tyrosine, and tryptophan biosynthesis, phenylalanine metabolism, ABC transporter activity, PPAR signaling pathway, linoleic acid metabolism, and unsaturated fatty acid biosynthesis. Conclusion: The ethanol extract of Gym can exhibit therapeutic effects on HUA by participating in amino acid biosynthesis pathways, amino acid metabolism, linoleic acid metabolism, ABC transport, and unsaturated fatty acid biosynthesis. This result provides a reference for elucidating the metabolic mechanism of Gym for the treatment of HUA.

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Comparative efficacy and safety of uricosuric agents in the treatment of gout or hyperuricemia: a systematic review and network meta-analysis

Cited by 3 publications

References 40 publications

Emerging Urate-Lowering Drugs and Pharmacologic Treatment Strategies for Gout: A Narrative Review

Emerging Urate-Lowering Drugs and Pharmacologic Treatment Strategies for Gout: A Narrative Review

Peptide NCTX15 derived from spider toxin gland effectively relieves hyperuricemia in mice

Multi-Omics analysis to identify the metabolic mechanism of the ethanol extract of Gymnadenia Conopsea R.Br. in hyperuricemia treatment

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