Comparative Efficacy of Antiherpes Drugs against Different Strains of Herpes Simplex Virus

Clercq, Erik De; Descamps, J.; Verhelst, Gabriël; Walker, Richard; Jones, A. S.; Torrence, Paul F.; Shugar, David

doi:10.1093/infdis/141.5.563

Cited by 610 publications

(287 citation statements)

References 54 publications

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“…4 . The C(7)=C (8) bond is parallel to the N(1)-C (6) bond and the corresponding distances are I C(7). .…”

Section: Propjvzj~l Groupmentioning

confidence: 99%

“…Beside the clinically effective 5-iodo (2), 5-trifluoromethyl(3), and 5-ethyl derivatives (4), several other 5-substituted 2'-deoxyuridines have been found to be potent antiviral agents (1). Among these analogues, (E)-5-(2-halovinyl)-2'-deoxyuridines (bromo and iodo derivatives) are the most potent and selective known inhibitors of Herpes simplex type I virus replication in cell cultures and experimental animals (5,6). 1t has also been shown that some 5-alkyl and alkenyl derivatives of 1-(P-D-arabinofuranosy1)uracil (araU) effectively inhibit HSV replication without significant effect on host cell growth (7,8).…”

Section: Introductionmentioning

confidence: 99%

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The crystal and molecular structure of 5-(propyn-1-yl)-1-(β-D-arabinofuranosyl)uracil. A very short C≡C triple bond

Cygler¹,

Anderson²,

Giziewicz³

et al. 1984

Can. J. Chem.

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, 147 (1984). The crystal structure of 5-(propyn-I-yl)-I-(P-D-arabinofuranosyl)uracil, an analog of the active antiherpes nucleoside I-(P-D-arabinofuranosyl)thymine, was determined by X-ray diffraction. The compound crystallizes in the space group P2,2,2, with a = 4.925(1), b = 14.326(2), c = 17.454 A. Reflections were measured on a diffractometer and the structure was solved by direct methods. Least-squares refinement converged at R = 0.032 for 1159 observed reflections. The sugar ring exhibits an 'E or a C(3')endo conformation with a pseudorotation angle P = 28.3" and puckering amplitude T,,, = 3 1.7". The orientation of the -CH20H side chain is g'. The base is in an at~ti conformation with respect to the sugar ring, with a glycosidic torsion angle x = 33.7". Changes in the C(5)-C(6) and C (6) [Traduit par le journal]

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“…4 . The C(7)=C (8) bond is parallel to the N(1)-C (6) bond and the corresponding distances are I C(7). .…”

Section: Propjvzj~l Groupmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The crystal and molecular structure of 5-(propyn-1-yl)-1-(β-D-arabinofuranosyl)uracil. A very short C≡C triple bond

Cygler¹,

Anderson²,

Giziewicz³

et al. 1984

Can. J. Chem.

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“…Compounds were tested for antiviral activity and cytotoxicity in various viral test systems, according to previously published procedures 23,24 . The results of in vitro evaluation are summarized in Tables 1-3.…”

Section: Pharmacological Activity Assessment and Resultsmentioning

confidence: 99%

Synthesis and antiviral activity of novel [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles, [1,2,4]triazolo[3,4-b] [1,3,4]thiadiazines and [1,2,4]triazolo[3,4-b][1,3,4] thiadiazepines

Farghaly¹,

Clercq²,

El‐Kashef³

2006

Arkivoc

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“…1) has the capability of interfering in the genetic makeup of the herpes virus by the substitution of thymidine in this structure. This leads to the generation of modified DNA resulting in impotent viral replication [2,3]. Several studies have suggested the extension of the use of IDU to the treatment of the cancer [4 -6].…”

Section: Introductionmentioning

confidence: 99%

Determination of Iodide and Idoxuridine at a Glutaraldehyde‐Cross‐Linked Poly‐L‐Lysine Modified Glassy Carbon Electrode

et al. 2005

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The detection limit (about 0.017 mg mL À1 ) for voltammetric determination of iodide (peak at þ 0.87 V vs. Ag/AgCl at pH 2) at a glutaraldehyde-cross-linked poly-l-lysine modified glassy carbon electrode involving oxidation to iodine was found to be several orders of magnitude lower than that for the voltammetric determination on a bare glassy carbon electrode. This method was applied successfully to the determination of iodide in two medicinal formulations. Idoxuridine was determined indirectly at the same electrode by accumulating it first at À 0.8 V vs. Ag/AgCl. At this potential the CÀI bond in the adsorbed idoxuridine is reduced giving iodide, which is then determined at the modified electrode. The method was successfully applied to the determination of idoxuridine in a urine sample.

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Comparative Efficacy of Antiherpes Drugs against Different Strains of Herpes Simplex Virus

Cited by 610 publications

References 54 publications

The crystal and molecular structure of 5-(propyn-1-yl)-1-(β-D-arabinofuranosyl)uracil. A very short C≡C triple bond

The crystal and molecular structure of 5-(propyn-1-yl)-1-(β-D-arabinofuranosyl)uracil. A very short C≡C triple bond

Synthesis and antiviral activity of novel [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles, [1,2,4]triazolo[3,4-b] [1,3,4]thiadiazines and [1,2,4]triazolo[3,4-b][1,3,4] thiadiazepines

Determination of Iodide and Idoxuridine at a Glutaraldehyde‐Cross‐Linked Poly‐L‐Lysine Modified Glassy Carbon Electrode

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