Comparative efficacy of butorphanol versus nalbuphine for balanced anaesthesia and post-operative analgesia in patients undergoing laparoscopic surgery

N, Vidhya; Prakash, .; Irshad, B; Kumar, Virendra

doi:10.18231/2394-4994.2019.0027

Cited by 2 publications

(2 citation statements)

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“…[14][15][16] In study by Rekhi et al they found nalbuphine (0.2mg/kg) effective in obtunding hemodynamic response to pneumoperitoneum, whereas Vidhya et al found the same dose less effective. 18,19 In our study, we found that heart rate did not increase at the time of creation of pneumoperitoneum or at any subsequent time points in both the groups. This may be attributed to the use of a balanced technique of anaesthesia for all the patients.…”

Section: Discussionmentioning

confidence: 41%

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Efficacy of nalbuphine for suppression of hemodynamic responses to pneumoperitoneum- A prospective randomised controlled study

Salhotra¹,

Singhal

Rautela³

et al. 2023

IJCA

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Pneumoperitoneum created during laparoscopic surgeries induces significant hemodynamic changes. This study was aimed to explore the efficacy of nalbuphine to suppress hemodynamic responses to pneumoperitoneum.This was a prospective randomised controlled study conducted on 80 ASA I/II patients between 18-60 yr after institutional ethics committee approval and written informed consent. Presence of pregnancy, multiple drug therapy, cardiovascular, renal or hepatic diseases were taken as exclusion criteria. Based on a computer generated random number table patients were allocated to one of the two groups; Group N: Nalbuphine 0.3 mg/kg and Group S: Normal saline. Hemodynamic parameters, time to request of rescue analgesic, sedation and side effects were recorded. Data was analysed using student t-test and Chi square/Fisher’s exact test, repeated measure ANOVA. A p-value<0.05 was taken as significant. Group N patients had lower heart rate after test drug and for the first 30 min and on deflation of pneumoperitoneum. The mean and systolic blood pressure decreased at the time of creation of pneumoperitoneum (p<0.001). VAS score was significantly lower in the first 30 min postoperatively in group N (p=0.004). Number of patients who requested for rescue analgesic within 2 h postoperatively, incidence of PONV and shivering were comparable. Sedation was higher in immediate postoperative period in group N (p=0.002). Nalbuphine provides stable hemodynamics for first 30 min after creation of pneumoperitoneum for laparoscopic procedures. It also provides postoperative analgesia for a short duration of 30 min.

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Section: Discussionmentioning

confidence: 41%

“…However, the results were found to be contradictory. 18,19 This study was planned to find out the haemodynamic effects of 0.3 mg/kg nalbuphine administered before creation of pneumoperitoneum in patients undergoing laparoscopic surgeries.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of nalbuphine for suppression of hemodynamic responses to pneumoperitoneum- A prospective randomised controlled study

Salhotra¹,

Singhal

Rautela³

et al. 2023

IJCA

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Comparison of the Efficacy of Intraperitoneal Instillation of Butorphanol Versus Nalbuphine as Adjuvants to Ropivacaine for Postoperative Pain Relief in Patients Undergoing Laparoscopic Cholecystectomy Under General Anesthesia

Mahajan

Singh

Kaur

et al. 2022

Anesthesia Essays &Amp; Researches

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Background and Aims: Postoperative pain after laparoscopic cholecystectomy is very common complication hindering the early return of routine activity. Since agonist opioids are not easily available, the most common drug used for intraoperative analgesia is intravenous butorphanol in our institute. The purpose of our study is to compare the analgesic effect of intraperitoneal butorphanol and nalbuphine as additives with ropivacaine in laparoscopic cholecystectomy for postoperative pain. Setting and Design: Randomized, double-blind prospective study undertaken after approval from the Institutional Ethics Committee. Materials and Methods: In this study, 90 patients undergoing laparoscopic cholecystectomy were randomly divided into three groups: group A received intraperitoneal ropivacaine 0.2% of 20 mL with butorphanol 2 mg; Group B received intraperitoneal ropivacaine 0.2% 20 mL with nalbuphine 10 mg; and Group C received intraperitoneal ropivacaine 0.2% 20 mL with 0.9% normal saline. The primary outcome was to compare the analgesic efficacy of butorphanol with nalbuphine and the duration of postoperative pain relief. The secondary outcomes included the comparison of hemodynamic parameters, frequency of rescue analgesia, and complications among the three groups. Statistical Analysis: The data analysis was carried out with ANOVA and Chi-square test using the SPSS software version 26.0. Results: The mean of the Numeric Rating Scale pain score was insignificant in Group A versus B at all-time intervals indicating similar efficacy of butorphanol and nalbuphine in terms of pain relief postoperatively. However, the time to first rescue analgesia was significantly higher in Group A (5.70 ± 3.57 h), followed by Group B (3.95 ± 2.06 h) and Group C (2.50 ± 1.24 h). Conclusion: Butorphanol is better analgesic than nalbuphine as postoperative pain-free period was relatively more with lesser complications.

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Comparative efficacy of butorphanol versus nalbuphine for balanced anaesthesia and post-operative analgesia in patients undergoing laparoscopic surgery

Cited by 2 publications

References 1 publication

Efficacy of nalbuphine for suppression of hemodynamic responses to pneumoperitoneum- A prospective randomised controlled study

Efficacy of nalbuphine for suppression of hemodynamic responses to pneumoperitoneum- A prospective randomised controlled study

Comparison of the Efficacy of Intraperitoneal Instillation of Butorphanol Versus Nalbuphine as Adjuvants to Ropivacaine for Postoperative Pain Relief in Patients Undergoing Laparoscopic Cholecystectomy Under General Anesthesia

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