Comparative efficacy of Chinese herbal injections for treating chronic heart failure: a network meta-analysis

Abstract

BackgroundOn account of deterioration of chronic heart failure (CHF) and extensive exploration of Chinese herbal injections (CHIs), we performed a network meta-analysis to investigate the efficacy of CHIs (Huangqi injection, Shenfu injection, Shengmai injection, Shenmai injection, Shenqi Fuzheng injection, Yiqifumai injection) on the basis of western medicine (WM) treatment in CHF.MethodsLiterature search was conducted in Embase, the Cochrane Library, Pubmed, Chinese Biological Medicine Database, China National Knowledge Infrastructure, Wanfang Database, Chinese Scientific Journal Database from inception to June 12nd 2017, and study selection was abided by a prior eligible criteria.ResultsUltimately, a total of 113 randomized controlled trials (RCTs) were enrolled. The clinical data of the effective clinical rate, left ventricular ejection fraction, cardiac output and others outcomes was estimated by Stata software and Winbugs software. Risk of bias was assessed by Cochrane Collaboration’s tools. Integrating the each outcome’s results, a combination of Shengmai injection/Shenmai injection and WM obtain a first rank in most outcomes, particularly primary outcomes.ConclusionsIn conclusion, on the basis of WM, Shengmai injection or Shenmai injection may be a perforable treatment in CHF. In terms of insufficient of this study, more high quality RCTs needed to implement to support our conclusions.Electronic supplementary materialThe online version of this article (10.1186/s12906-018-2090-3) contains supplementary material, which is available to authorized users.

Traditional Chinese medicine for ischemic heart disease: clinical manifestations and objective indicators

“…Considering almost every RCT was conducted on the basis of conventional treatment in both TCM group and control group, it is safe to say that TCM can improve clinical e cacy as complementary to western medicine. The improvement of clinical e cacy was coincided with previous reports [25][26][27][28][29][30] .…”

Exploring Molecular Mechanism of Huangqi in Treating Heart Failure Using Network Pharmacology

“…Previous studies reveal that Huangqi can improve cardiovascular function, protect myocardial cells, increase coronary blood flow, enhance myocardial contractility, and have positive inotropic effect on the heart [6,7]. Moreover, Huangqi injection is approved by China Food and Drug Administration and has already achieved positive effect in treating HF in clinical trials [8]. However, the ingredients and targets of Huangqi in the treatment of HF have yet to be further explored.…”

Comparative efficacy of Chinese herbal injections combined with azithromycin for mycoplasma pneumonia in children: A Bayesian network meta‐analysis of randomized controlled trials

“…Chinese herbal injection (CHI) is a new formulation with rapid action and high bioavailability and made from components extracted from traditional Chinese herb using modern technology . It is widely used in the treatment of cardiovascular diseases, cancers and respiratory diseases . Although numerous traditional pairwise meta‐analytic reviews have reported on the efficacy of many CHIs that could be used to treat mycoplasma pneumonia in children, the effect of which kind of injection is the best remains unclear.…”

“…18 It is widely used in the treatment of cardiovascular diseases, cancers and respiratory diseases. [19][20][21][22][23][24] Although numerous traditional pairwise metaanalytic reviews have reported on the efficacy of many CHIs that could be used to treat mycoplasma pneumonia in children, [25][26][27][28] the effect of which kind of injection is the best remains unclear. This is because the traditional pairwise meta-analysis can only achieve direct comparison between the two interventions and cannot comprehensively evaluate the efficacy of various interventions.…”