Comparative Efficacy of Different Oral Doses of Clindamycin in Preventing Post-Operative Sequelae of Lower Third Molar Surgery—A Randomized, Triple-Blind Study

Janas-Naze, Anna; Torbicka, Gaja; Chybicki, Damian; Lipczyńska-Lewandowska, Małgorzata; Zhang, Wei

doi:10.3390/medicina58050668

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…A study indicates that "lower doses of clindamycin, when administered for shorter periods, are beneficial in relieving pain and reducing postoperative complications after surgical removal of third molars" [21].…”

Section: Source: Own Authorship 2023mentioning

confidence: 99%

Clinical Relevance of Antibiotic Prophylaxis in Dental Surgical Procedures: A Systematic Review

Duarte,

Barbosa,

Oliveira

et al. 2023

JAMMR

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Background: Antibiotic prophylaxis is a procedure performed with the use of antibiotics to prevent the patient from contracting some type of infection during surgical procedures. Aim: To analyze the clinical relevance of using antibiotic prophylaxis before dental surgical procedures. Methods: This is a systematic review of the qualitative literature in the PubMed, LILACS and Medline databases, using the health descriptors "Antibiotic Prophylaxis", "Dentistry" and "Oral Surgical Procedures" and selected articles in English and Portuguese published between 2018 and 2022. Articles that did not follow the eligibility criteria and that did not address relevant data for the present study were excluded. Abstracts were also excluded; duplicate articles; review articles; meta-analysis and studies not related to dentistry. Results: After the research, considering the inclusion and exclusion criteria and thematic relevance, 15 articles were selected. Upon analysis, it was found that the effect of antibiotic prophylaxis in case of dental surgeries is small and may not be clinically relevant. Some improvement in postoperative symptoms in dental surgeries can be explained by the decrease in bacterial contamination of the surgical wound, and antibiotic prophylaxis is associated with a lower need for analgesic administration. Amoxicillin is considered the antibiotic of choice for antibiotic prophylaxis in clinical dental practice. In cases of penicillin allergy, clindamycin is often prescribed as a substitute of choice, with lower doses of clindamycin when given over shorter periods of time beneficial in relieving pain and reducing postoperative complications. Conclusion: Regarding the analyzed studies, it appears that the effect of antibiotic prophylaxis in cases of dental surgery may be small and not clinically relevant. In view of this, more studies on the clinical relevance of antibiotic prophylaxis in dental procedures should be carried out and more factors should be addressed in research to increase the scope of analysis.

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Section: Source: Own Authorship 2023mentioning

confidence: 99%

Clinical Relevance of Antibiotic Prophylaxis in Dental Surgical Procedures: A Systematic Review

Duarte,

Barbosa,

Oliveira

et al. 2023

JAMMR

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Severe Bilateral Sialadenitis of the Mandibular and Parotid Salivary Glands with Severe Panniculitis in a 2-Year-old Standard Poodle

Yee,

Cyrus Parambeth,

Kawalilak

et al. 2024

J Vet Dent

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A 2-year-old male neutered Standard Poodle weighing 17.9 kg was presented to their primary care veterinarian for enlarged bilateral submandibular swellings following an interdog altercation sustained in the previous weeks. Cytology performed following fine-needle aspirates of the regions of swelling was inconclusive, and the patient was treated empirically with Clavaseptin. Despite treatment, the submandibular swellings continued to enlarge, and right-sided intermittent epistaxis was reported. On biochemical profile, there was mild hypercalcemia and mild hyperglobulinemia. The computed tomography (CT) findings were indicative of severe multifocal sialadenitis with severe regional cellulitis and inflammatory lymphadenopathy. Histopathology and cytology results described mixed inflammation of the salivary gland. Methenamine silver staining and Fite's acid-fast staining were negative. Aerobic and anaerobic cultures were negative. Targeted, next-generation DNA sequencing detected no known fungi or bacterial pathogens. These findings were consistent with the diagnosis of severe bilateral mandibular sialadenitis, panniculitis, and lymphadenopathy. The patient was prescribed enrofloxacin, clindamycin, phenobarbital, and prednisolone for 1 month. One week after initiating treatment, the patient had a significant reduction in size of the salivary glands. CT imaging was helpful in the diagnosis of this patient and allowed the clinician to identify which submandibular anatomical structures were abnormal, guiding subsequent diagnostic decisions to provide medical management to resolve the condition.

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Selective Outcome Reporting Concerning Antibiotics and Third Molar Surgery

Fagoni,

Rafalovich,

Brozoski

et al. 2024

Preprint

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Objectives This study evaluates the selective outcome reporting (SOR) in clinical trials on antibiotic use in third molar surgeries. It explores how SOR may bias results and affect systematic reviews, potentially leading to misinterpretations of intervention efficacy. Materials and Methods A search was conducted on "ClinicalTrials.gov" and the "Brazilian Registry of Clinical Trials" using the terms "third molar" and "antibiotics" up to October 2024. Two independent researchers selected eligible clinical trials. Data were extracted from registered protocols and corresponding publications. Discrepancies were analysed using established criteria, and the risk of bias was assessed with Risk of Bias2. Results Discrepancies between protocols and publications were found in 83.3% of cases, affecting outcomes in 58.3% of studies. SOR significantly influenced results in studies with three or more discrepancies. Seventy percent of studies assess pain post-antibiotic therapy; of those, 50% found significant results. Only 30% of studies showed significant reductions in trismus and edema with antibiotic use. Risk of bias varied significantly across studies. Conclusions The high rate of selective reporting stresses the need for transparent studies to clarify the role of antibiotics in the perioperative period. Researchers should adhere to best clinical practices, including protocol registration, accurate sample size calculations, and precision in reporting. Journals and reviewers must prioritize transparency to reduce bias and improve research quality. Clinical Relevance This study emphasizes the impact of SOR in clinical trials using antibiotics in third molar surgery. Clinicians should be more cautious in reading evidence based on randomized clinical trials with SORs.

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Comparative Efficacy of Different Oral Doses of Clindamycin in Preventing Post-Operative Sequelae of Lower Third Molar Surgery—A Randomized, Triple-Blind Study

Cited by 3 publications

References 35 publications

Clinical Relevance of Antibiotic Prophylaxis in Dental Surgical Procedures: A Systematic Review

Clinical Relevance of Antibiotic Prophylaxis in Dental Surgical Procedures: A Systematic Review

Severe Bilateral Sialadenitis of the Mandibular and Parotid Salivary Glands with Severe Panniculitis in a 2-Year-old Standard Poodle

Selective Outcome Reporting Concerning Antibiotics and Third Molar Surgery

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