Comparative Efficacy Study of N-Chromosome Royal Jelly Versus Semelil (ANGIPARS) on Wound Healing of Diabetic Rats

Abstract

Objective: The healing effects of two different dilutions (5 & 100%) of N-Chromosome Royal Jelly and ANGIPARS ointment were investigated and measured on experimental injuries in streptozotocin (STZ)- induced diabetic rats. This study investigated the healing effects of 2 different N Chromosome Royal Jelly dilutions on injuries of STZ-induced diabetic rats.
 Materials and Methods: For diabetes induction, male Wistar rats received STZ (55 mg/kg) intraperitoneally and plasma glucose level measurement after 72 hours demonstrated diabetes induction. Rats were randomly divided into 5 groups of 6 members and one square centimeter (cm2 ) wound was surgically induced in the dorsal region of each rat. The test groups were treated with ANGIPARS, undiluted royal jelly N chromosome, and royal jelly N chromosome 5% separately. The control groups were including non-diabetic and untreated diabetic rats.
 Results: The findings indicate a significant acceleration in wound healing of the diabetic rats treated by ANGIPARS ointment or royal jelly N chromosomes 5%. RJ also shortened the healing period of desquamated skin lesions. Thus, RJ possesses an anti-inflammatory action and is able to augment wound healing, but does not have an insulin-like action in streptozotocin-diabetic rats.
 Conclusion: Regarding the mentioned findings, royal jelly as a natural product may play an effective role in treating chronic wounds in mice, which makes it a proper candidate for use in human wound repair. Nonetheless, it seems that determination of the suitable dilution of this compound will result in better effects, thus more studies are recommended.

Royal Jelly: Biological Action and Health Benefits

“…Macrophages are also important for wound healing by dampening inflammation. They produce various regulators that promote an inflammatory response and remove bacteria and necrotic tissue through the phagocytic activity [ 36 , 313 , 314 , 315 , 316 , 317 ].…”

“…In general, it has been shown that RJ and its components promote wound healing at both animal and cellular levels [ 318 , 319 , 320 , 321 , 322 , 323 , 324 , 325 , 326 ]. Some components of RJ show anti-inflammatory effects (SA, 10-HDA, and 10-HDAA), some components promote proliferation and migration (MRJPs, especially MRJP2, MRJP3, and MRJP7), whereas some components stimulate regenerative activities (royalactin, royalisin, and 10-HDA) [ 313 , 314 , 315 , 316 , 317 , 318 , 319 , 320 , 321 , 322 , 323 , 324 , 325 ].…”

“…In streptozotocin-induced diabetic rats, the wound-healing activity of RJ was attributed to its royalisin-mediated antimicrobial effects, the anti-inflammatory action, and the ability to reduce exudation and collagen formation in granulation tissue [ 313 , 314 ]. Kohno et al [ 36 ] suggested that the anti-inflammatory actions of RJ on the inhibition of the proinflammatory cytokine are released by activated macrophages as well as the scavenging activity.…”

“…Kohno et al [ 36 ] suggested that the anti-inflammatory actions of RJ on the inhibition of the proinflammatory cytokine are released by activated macrophages as well as the scavenging activity. In streptozotocin-induced diabetic rats, RJ also shortened the time required for the recovery of desquamated skin lesions [ 313 , 314 ]. El-Gayar et al [ 314 ] have shown the wound healing effect of RJ in a rat model of an MRSA skin infection.…”