Comparative enhancing effects of electret with chemical enhancers on transdermal delivery of meloxicam in vitro

Hou, Xiaoning; Jiang, Jian; Li, G D; Liang, Yuanyuan; Xin, Xu

doi:10.1088/1742-6596/142/1/012015

Cited by 16 publications

(8 citation statements)

References 12 publications

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“…Tu et al electret could effectively enhance the transdermal delivery of several drugs of low molecular weight, such as methyl salicylate, 19 meloxica, 20 lidocaine 21 and cyclosporine A (a small peptide, 1024 Da). 22 However, our results showed that electret could not significantly promote the transdermal delivery of protein drugs with higher molecular weights (Tu et al, unpublished data, 2011), which is consistent with the result obtained by Murthy et al 23 that electret could not enhance the transdermal delivery of protein drugs with high molecular weights .1 kDa.…”

mentioning

confidence: 99%

Promotion of the transdermal delivery of protein drugs by <em>N</em>-trimethyl chitosan nanoparticles combined with polypropylene electret

Tu¹,

Wang²,

Lü³

et al. 2016

IJN

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mentioning

confidence: 99%

Promotion of the transdermal delivery of protein drugs by <em>N</em>-trimethyl chitosan nanoparticles combined with polypropylene electret

Tu¹,

Wang²,

Lü³

et al. 2016

IJN

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“…A comparative study between electret and chemical enhancers using patch as carrier was carried out. The 10 hours cumulative permeation amount of MX achieved 30.15 mg/cm 2 for electret group, which showed the highest penetration effect (Cui et al, 2008).…”

Section: Patchesmentioning

confidence: 90%

Strategies for meloxicam delivery to and across the skin: a review

Chen

Gao

2016

Drug Delivery

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Although meloxicam (MX) is relatively safer than other NSAIDs, adverse effects relating to the gastro-intestinal tract are still a problem when administrated MX at high doses and on the longterm treatment. Drug delivery via skin provides an attractive alternative to oral administration, but is limited by the first layer of the skin-stratum corneum. Studies have been focused on developing effective methods to break the barrier of stratum corneum for enhancing delivery of MX to and across the skin. Strategies including formulation optimizing, chemical modification and physical enhancements to transiently reduce stratum corneum barrier function have been introduced. This article reviews the current state of the techniques in the delivery of MX to and across the skin, and it also includes the profiles of pharmacokinetic and safety related with skin delivery of MX.

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“…Meloxicam activity was not different in the 1% and 2% groups ( Fig.1-3). Cui et al (2008) reported no difference in 1, 3, or 5% meloxicam patches, and NSAID dose did not influence pain control in osteoarthritis patients (Yocum et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Anti-Hyperalgesic Effects of Meloxicam Hydrogel via Phonophoresis in Acute Inflammation in Rats; Comparing Systemic and Topical Application

Kim¹,

Kim²,

Seo³

et al. 2009

Biomolecules and Therapeutics

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-The aim of this study was to determine if a meloxicam hydrogel could be administered in vivo via phonophoretic transdermal delivery using pulsed ultrasound by examining its anti-hyperalgesic effects in a rat carrageenan inflammation model. Carrageenan (1%) was injected into the plantar surface of the right hindpaw, and meloxicam hydrogel was administered via phonophoretic transdermal delivery. Changes in the mechanical and thermal hyperalgesia, as well as swelling, showed that phonophoretic delivery of meloxicam exhibited significantly better anti-hyperalgesic and anti-inflammatory effects than pulsed ultrasound. Topical and systemic application of meloxicam hydrogel using phonophoresis showed similar anti-hyperalgesic effects. These findings suggest that the transdermal administration of a meloxicam hydrogel using phonophoresis by pulsed ultrasound might be useful for treating acute inflammation.

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Comparative enhancing effects of electret with chemical enhancers on transdermal delivery of meloxicam in vitro

Cited by 16 publications

References 12 publications

Promotion of the transdermal delivery of protein drugs by <em>N</em>-trimethyl chitosan nanoparticles combined with polypropylene electret

Promotion of the transdermal delivery of protein drugs by <em>N</em>-trimethyl chitosan nanoparticles combined with polypropylene electret

Strategies for meloxicam delivery to and across the skin: a review

Anti-Hyperalgesic Effects of Meloxicam Hydrogel via Phonophoresis in Acute Inflammation in Rats; Comparing Systemic and Topical Application

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