Comparative evaluation of aflatoxin and mineral binding activity of molecular imprinted polymer designed for dummy template using in vitro and in vivo models

Arak, Homa; Torshizi, Mohammad Amir Karimi; Hedayati, Mehdi; Rahimi, Shaban

doi:10.1016/j.toxicon.2019.05.005

Cited by 12 publications

(4 citation statements)

References 47 publications

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“…After polymerization, the resulting block polymer must be ground, crushed, and sieved so that the template molecule can be extracted from the polymer. For example, Arak et al 25 employed the bulk polymerization method in order to prepare an AF-MIP using DMC as the template, MAA as the monomer, and EDMA as a cross-linker. The amelioration of AF in ducklings was examined by feeding the ducks the synthesized MIPs to target the AF B1 (AFB1) analog.…”

Section: Lump-bulk Polymerizationmentioning

confidence: 99%

Application of molecularly imprinted polymers for the separation and detection of aflatoxin

Pan

et al. 2020

Journal of Chemical Research

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Aflatoxins are extremely harmful carcinogens to humans and animals. In recent years, attention has been directed toward the application of molecular imprinting polymers for the separation and detection of aflatoxin. In this review, polymerization methods for the preparation of molecular imprinting polymers for aflatoxin detection, such as lump-bulk polymerization, spherical molecular imprinting polymer synthesis, surface-imprinted polymerization, and electropolymerization, are described. The applications of molecular imprinting polymers in solid-phase extraction, biosensors, and the surface-enhanced Raman detection of aflatoxin are also reviewed in this paper.

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Section: Lump-bulk Polymerizationmentioning

confidence: 99%

Application of molecularly imprinted polymers for the separation and detection of aflatoxin

Pan

et al. 2020

Journal of Chemical Research

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“…Aflatoxins (AFs) are a group of compounds having as basic structure a coumarin and a double-furan ring and are produced as secondary metabolites by fungi of Aspergillus family as A. flavus, A. parasiticus, and A. nomius [ 1 , 2 , 3 ]. AFs can contaminate foodstuffs such as cereals, nuts, fruits, dried fruits, and oilseeds in field (harvest period) or during drying/storage [ 4 , 5 , 6 , 7 ]. The ingestion of large amounts of AFs over a short period can cause vomiting, abdominal pain, swelling, jaundice, acute liver damage, and even death; on the other hand, long-period ingestion of low amounts of AFs is also considered a significant risk for health [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Study on Molecularly Imprinted Polymers Obtained Sonochemically for the Determination of Aflatoxins in Food

Palmieri

Elfadil²,

Fanti³

et al. 2023

Molecules

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Aflatoxins (AFs) are fungi secondary metabolites produced by the Aspergillus family. These compounds can enter the food chain through food contamination, representing a risk to human health. Commercial immunoaffinity columns are widely used for the extraction and cleanup of AFs from food samples; however, their high cost and large solvent consumption create a need for alternative strategies. In this work, an alternative strategy for producing molecularly imprinted polymers (MIPs) was proposed to extract aflatoxins AFB1, AFB2, AFG1, and AFG2 from complex food samples, using liquid chromatography coupled with tandem mass spectrometry (LC–MS/MS). The MIPs were synthesized via a low-cost and rapid (5 min) sonochemical free-radical polymerization, using 1-hydroxy-2-naphthoic acid as a dummy template. MIPs-based solid phase extraction performance was tested on 17 dietary supplements (vegetables, fruits, and cereals), obtaining appreciable recovery rates (65–90%) and good reproducibility (RSD ≤ 6%, n = 3); the selectivity towards other mycotoxins was proved and the data obtained compared with commercial immunoaffinity columns. The proposed strategy can be considered an alternative affordable approach to the classical immunoaffinity columns, since it is more selective and better performing.

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“…Enabling MIPs to resist harsh physical conditions (extreme pH and temperatures) that would render biological receptors useless [ [7] , [8] , [9] ]. This has led to MIPs being deployed into numerous fields, including chemical separation, chromatography, affinity materials for sensors, binding assays, catalysis, and sorbents for solid phase extraction, to name just a few [ [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] ].…”

Section: Introductionmentioning

confidence: 99%

MIPs for commercial application in low-cost sensors and assays – An overview of the current status quo

Lowdon

Diliën

Singla

et al. 2020

Sensors and Actuators B: Chemical

183

103

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Highlights The review aims to summarize recent commercially interesting innovations in MIP-based sensor design. In addition to sensors, commercially viable assays based on MIPs are analysed and recent advances are summarized and discussed. The review also analyses how commercial MIP companies could contribute to a next step in the commercialization of MIP-based detection systems. The review contains a critical analysis and discussion on MIP-based sensors and assay commercialization as well as an outlook/recommendation for the future.

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Comparative evaluation of aflatoxin and mineral binding activity of molecular imprinted polymer designed for dummy template using in vitro and in vivo models

Cited by 12 publications

References 47 publications

Application of molecularly imprinted polymers for the separation and detection of aflatoxin

Application of molecularly imprinted polymers for the separation and detection of aflatoxin

Study on Molecularly Imprinted Polymers Obtained Sonochemically for the Determination of Aflatoxins in Food

MIPs for commercial application in low-cost sensors and assays – An overview of the current status quo

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